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malignant fibrous histiocytoma of the bone in a traumatic amputation stump: A case report and review of the literature

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World Journal of Clinical Cases 2021年第26期9卷 7930-7936页

作者： Ke-Yang Zhao Xu Yan Peng-Fei Yao Jiong Mei Department of Orthopedic Surgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China Department of Orthopedics Huainan First People's HospitalHuainan 200233Anhui ProvinceChina

BACKGROUND malignant fibrous histiocytoma(MFH)is one of the most common soft tissue sarcomas among *** is characterized by large size,high grade,and biological *** are many reports of MFH after local stimulation,such as bone fracture,implants,and chronic *** this paper,we report a patient who developed MFH 6 years after amputation,suggesting that wound healing and mechanical force play a role in the local stimulation of this *** SUMMARY A 66-year-old man complained of persistent pain in his residual *** had undergone amputation surgery due to a traffic accident 6 years *** examination showed tenderness but no abnormalities in *** radiographs and magnetic resonance imaging supported the diagnosis of a tumor,and a biopsy confirmed that the lesion was *** patient received neoadjuvant chemotherapy and left hip *** the 6-mo followup,there were no symptoms of *** Postsurgery MFH has been reported before,and many studies have attributed it to the biological effects of *** case report shows that this disease can develop without an implant and thus highlights the importance of local *** wound-healing process and mechanical force can both promote this tumor,but whether they directly cause MFH needs further investigation.

关键词： malignant fibrous histiocytoma Postamputation pain Traumatic amputation Case report

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A comparison of malignant fibrous histiocytoma of head, neck and extremities

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Chinese Medical Journal 2000年第6期113卷 52-55页

作者：吴雪溪祁永发唐平章 Department of Head and Neck Surgery Cancer Hospital Peking Union Medical College Beijing 100021 China Department of Head and Neck Surgery Cancer Hospital Beijing 100021 China

Objective To compare the epidemiology, local and regional invasion and prognosis of head and neck malignant fibrous histiocytoma (MFH) and extremity MFH Methods Between January 1, 1972 and December 31, 1993, 173 patients with MFH (71 head and neck, 102 extremities and trunk) were referred to the Cancer Hospital for surgical treatment They were 101 men and 72 women, with age ranging from 13 to 83 years (median: 45 years) The extent of surgery was classified into radical, wide and local resection Results For head and neck, local recurrence of MFH after wide resection was 80 4% (37/46), compared with 36.4% (8/22) after radical surgery ( P =0 000) The five year survival was 50 79% in all the head and neck patients (74 75% in patients free of local recurrence, 37 74% in patients with local recurrence; P =0 0181), compared with 70 71% in extremity patients ( P =0 0005) Repeated surgery after recurrence of MFH could cure 40 9% of the head and neck patients and 80 7% of the extremity patients Conclusion Inadequate resection of head and neck MFH in initial surgery is associated with a high incidence of local recurrence, which is always correlated with worse prognosis Repeated surgery for recurrent head and neck MFH is not as effective as for recurrent extremity MFH Therefore, we suggest that the initial surgery for head and neck MFH should be as radical as allowed to avoid a possible local recurrence

关键词： malignant fibrous histiocytoma head and neck surgical treatment

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Early Recurrence of a Cardiac malignant fibrous histiocytoma

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World Journal of Cardiovascular Surgery 2013年第5期3卷 139-142页

作者： Laura Reija Lopez Angela Granda Bauza Jose Manuel Martínez Cereijo Jose Rubio Alvarez Belén Adrio Nazar Juan Sierra Quiroga Complexo Hospitalario Universitario de Santiago de Compostela A CorunaSpain

malignant fibrous histiocytoma (MFH) is a rare tumor of the heart and the patients with these tumors usually have a poor prognosis. We report a case of MFH with an origin from the left superior pulmonary vein, involving the left atrium and protruding through the mitral valve, which needed urgent surgery. Complete resection was performed but local recurrence was detected one month later.

关键词： malignant fibrous histiocytoma Early Recurrence

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Large,unresectable malignant fibrous histiocytoma:PET/CT-guided treatment with a multidisciplinary,minimally invasive approach

Large,unresectable malignant fibrous histiocytoma:PET/CT-gui...

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中国(第七届)肿瘤微创治疗学术大会暨世界影像导引下肿瘤微创治疗学会成立筹备大会

作者： Chuanxing Li,Dong Chen,Ketong Wu,Sheng Peng,Fujun Zhang Department of Medical Imaging & Interventional Radiology,Cancer Center and State Key Laboratory of Oncology in South China,Sun Yat-sen University,Guangzhou,510060,P.R.China.

Purpose To evaluate the effectiveness and safety of a PET/CT-guided,multidisciplinary,minimally invasive approach to the treatment of patients with large,unresectable,malignant fibrous *** approach includes microwave ablation and absolute alcohol therapy combined with 125I seed *** and Methods Seven patients(5 males and 2 females,42-48 years-old,mean 49.7 years-old) with large,unresectable malignant fibrous histiocytoma participated in this *** tumors had an average maximum diameter of 14.1 cm(10.0-19.0 cm) and were treated using a PET/CT-guided,multidisciplinary,minimally invasive *** patients received a PET/CT scan 2 months after the ***-up was conducted for an average of 35.7(2-45) months to determine the local control rate,overall survival rate,and clinical *** Follow-up times ranged from 2 to 45 *** was significantly relieved in patients treated with multidisciplinary,minimally invasive *** on PET/CT, complete response was achieved in 5 patients(71.4%),partial response in the other 2 patients(28.6%).The response rate of this multidisciplinary,minimally invasive treatment was 100%.The median survival time was 35.7 *** patients were alive 2 years after the *** patients were still alive after 3 *** patient died from cachexia and infection in the 3rd year,and another died of lung dysfunction from pulmonary metastases in the 2nd *** 3-year survival rate was 71.4%.The long-term complications included hyperpigmentation at the operative sites(n = 5) and insensible feeling at the ablation sites(n=3).Conclusion:PET/CT-guided multidisciplinary,minimally invasive approach is an effective,safe,and feasible means of treating large,unresectable malignant fibrous histiocytoma with minimal damage and few complications,but large-scale randomized clinical trials are necessary to confirm this assessment.

关键词： malignant fibrous histiocytoma multidisciplinary approach PET-CT microwave ablation absolute alcohol 125I brachytherapy

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malignant transformation of aneurysmal bone cysts： a case report

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Chinese Medical Journal 2009年第1期122卷 110-112页

作者： MEI Jiong GAO You-shui WANG Shu-qing CAI Xuan-song Department of Orthopedics Tongji Hospital Tongji University Shanghai 200065 China

An aneurysmal bone cyst is a non-neoplastic, .destructive and expansile lesion consisting of a＂blood-filled sponge＂ that is defined to represent a benign reactive vascularity. Szendroi et al suggested that the aneurysmal bone cyst corresponds to a haemodynamic disturbance that is primary or secondary venous malformation of the bones. The association with trauma including fracture has also been noted and 25%-71% of such patients have a history of trauma. Conventionally, malignant transformation of aneurysmal bone cysts is perceived as a rare occurrence except those induced by irradiation. Both malignant fibrous histiocytoma and osteosarcoma have been reported in the malignant transformation cases.

关键词： aneurysmal bone cyst prosthesis implantation malignant fibrous histiocytoma

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Myxofibrosarcoma of the scalp with difficult preoperative diagnosis:A case report and review of the literature

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World Journal of Clinical Cases 2020年第11期8卷 2350-2358页

作者： Xiao-Ting Ke Xiong-Feng Yu Ji-Yang Liu Fang Huang Mei-Gui Chen Qing-Quan Lai Department of CT/MRI The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina

BACKGROUND A myxofibrosarcoma(MFS)is a malignant fibroblastic tumor that tends to occur in the lower and upper *** reported incidence of head and neck MFSs is extremely *** report a 46-year-old male with“a neoplasm in the scalp”who was hospitalized and diagnosed with an MFS(highly malignant with massive necrotic lesions)based on histologic and immunohistochemistry *** magnetic resonance imaging manifestations did not demonstrate the“tail sign”mentioned in several studies,which resulted in a great challenge to establish an imaging *** treatment plan is closely associated with the anatomic location and histologic grade,and more importantly,aggressive surgery and adjuvant radiotherapy may be ***,we report the case and share some valuable information about the *** SUMMARY A 46-year-old male with“a neoplasm in the scalp for 6 mo”was ***,the tumor was about the size of a soybean,without algesia or *** patient ignored the growth,did not seek treatment,and thus,did not receive ***,the tumor increased to the size of an egg;there was no bleeding or *** family history was *** abnormalities were found upon laboratory testing,including routine hematologic,biochemistry,and tumor *** tomography showed an ovoid mass(6.25 cm×3.29 cm×3.09 cm in size)in the left frontal scalp with low density intermingled with equidense strips in adjacent areas of the *** resonance imaging revealed a lesion with an irregular surface and an approximate size of 3.55 cm×6.34 cm in the left frontal region,with clear boundaries and visible *** areas of the skull were damaged and the dura mater was *** enhancement showed an uneven enhancement *** was performed and postoperative adjuvant radiotherapy was administered to avoid recurrence or *** post-operative pathologic diagnosis confirmed an MFS.A repeat computed

关键词： malignant fibrous histiocytoma Myxofibrosarcoma Scalp Magnetic resonance imaging Treatment Case report

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Undifferentiated pleomorphic sarcoma of the liver presenting as a unilocular cyst

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Hepatobiliary & Pancreatic Diseases International 2009年第5期8卷 541-543页

作者： Hyun-Soo Kim Gou Young Kim Sung-Jig Lim Sang Mok Lee Youn Wha Kim Departments of Pathology School of MedicineKyung Hee University1 Hoegi-dongDongdaemun-gu130-702 SeoulSouth Korea Departments of Surgery School of MedicineKyung Hee University1 Hoegi-dongDongdaemun-gu130-702 SeoulSouth Korea

BACKGROUND:A malignant fibrous histiocytoma,recently referred to as an undifferentiated pleomorphic sarcoma (UPS),is very rare in the liver,and only 34 cases of primary hepatic malignant fibrous histiocytoma have been reported in the English literature. METHODS:We report a rare case of a hepatic UPS presenting as a unilocular cystic lesion with respect to histopathologic features,the newly revised diagnostic criteria,and the differential diagnosis. RESULTS:A 60-year-old man presented for evaluation of epigastric pain of 7 months *** computed tomography revealed a hypodense,unilocular cystic mass in the right lobe of the liver,measuring 14.0×11.1 cm.A right lobectomy was ***,the cut surface showed a single,well-circumscribed unilocular cystic tumor mass containing dark red-brown necrotic debris and blood clots, which occupied most of the ***,the tumor consisted of haphazardly arranged mononuclear pleomorphic tumor cells,admixed with abundant osteoclast- like multinucleated giant ***,the tumor cells expressed vimentin *** histopathologic and immunohistochemical findings were compatible with a *** patient is alive and well 41 months after surgery without recurrence. CONCLUSIONS:Clinically,most of the hepatic UPSs are solid *** two cases have presented as multilocular cystic masses.A primary hepatic UPS presenting as a unilocular cyst has never been reported.A UPS should be included in the differential diagnosis of unilocular cystic lesions in the liver.

关键词： undifferentiated pleomorphic sarcoma malignant fibrous histiocytoma liver unilocular cyst

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