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Comparison of Biopsy Results and Imaging Methods,in the Diagnosis of Breast Cancer

Surgical Science 2012年第9期3卷 445-451页

作者： Mehmet Ali Eryilmaz Ozgur Oner Ahmet Okus Omer Karahan Said Bodur Serden Ay Seher Civcik General Surgery Clinic Konya Training and Research HospitalKonyaTurkey Radyology Clinic Konya Training and Research HospitalKonyaTurkey Department of Public Health Meram Faculty of MedicineSelcuk UniversityKonyaTurkey Konya Early Diagnosis of Cancer-Screening and Education Center Kanser Erken Teshis-Tarama ve Egitim Merkezi(KETEM)KonyaTurkey

Purpose: In this study, we aimed at comparing the sensitivity and selectivity rates of Ultrasonography (USG), Mamography (MG) and magnetic resonance (MR), based on the biopsy results of breast mass lesions. Materials and methods: Between January 2009 and December 2010 in Konya Training and Research Hospital the biopsy results and reports of imaging tecniques such as USG, MG and MR, were obtained from the hospital automation. The sensitivity and selectivity of the USG, MG and MR were calculated. Results: The avarage age of the 112 patients included in this study is 49 ± 10 (23 - 71). 27 (24%) of the patients were found to have breast cancer after the histopathologic examination. USG was used with the 95 (94%) of the patients and 17 (18%) of the patients were diagnosed to have cancer. MG was used with the 75 (67%) of the patients and 15 (20%) of the patients were diagnosed to have cancer, and MR was used with the 112 (100%) of the patients and 25 (22%) of the patients were diagnosed to have cancer. In the pathologic diagnosis of cancer, the sensitivity of USG was found 85%, the sensitivity of MG was found 89%, and the sensitivity of MR was found 92%. The selectivity of these tecniques were 58%, 87% and 57% respectively. Conclusion: MR and MG have similar sensitivity rates in the diagnosis of breast cancer. Breast MR is an appropriate imaging tecnique that can be used in suitable indications in addition to USG and MG.

关键词： Breast Cancer magnetic resonance Mamography Ultrasonography

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Focal liver lesions found incidentally

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World Journal of Hepatology 2016年第9期8卷 446-451页

作者： Abdullah A Algarni Abdullah H Alshuhri Majed M Alonazi Moustafa Mabrouk Mourad Simon R Bramhal Liver Unit Prince Sultan Military Medical City Department of General Surgery Wye Valley NHS Trust

Incidentally found focal liver lesions are a commonfinding and a reason for referral to hepatobiliary *** are often discovered in patients with history of liver cirrhosis,colorectal cancer,incidentally during work up for abdominal pain or in a trauma *** points should considered during history taking such as risk factors of liver cirrhosis;hepatitis,alcohol consumption,substance exposure or use of oral con-traceptive pills and metabolic *** blood count,liver function test and tumor markers can act as a guide to minimize the differential diagnosis and to categorize the degree of liver *** should start with B-mode *** available,contrast enhanced ultrasound is a feasible,safe,cost effective option and increases the ability to reach a *** enhanced computed tomography should be considered *** is more accurate in diagnosis and better to study anatomy for possible *** enhanced magnetic resonance is the gold standard with the highest *** doubt still remains,the options are biopsy or surgical excision.

关键词： Focal liver lesions B-mode ultrasound Ultrasound magnetic resonance Fine needle biopsy Computed tomography

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Tracking of Labelled Stem Cells Using Molecular MR Imaging in a Mouse Burn Model <i>in Vivo</i>as an Approach to Regenerative Medicine

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Advances in Molecular Imaging 2021年第1期11卷 1-15页

作者： Zeba Qadri Valeria Righi Shasha Li A. Aria Tzika MGH NMR Surgical Laboratory Center for Surgery Innovation and Bioengineering Department of Surgery Massachusetts General and Shriners Burn Hospitals Harvard Medical School Boston USA Athinoula A. Martinos Center of Biomedical Imaging Department of Radiology Massachusetts General Hospital Harvard Medical School Charlestown USA

Therapies based on stem cell transplants offer significant potential in the field of regenerative medicine. Monitoring the fate of the transplanted stem cells in a timely manner is considered one of the main limitations for long-standing success of stem cell transplants. Imaging methods that visualize and track stem cells in vivo non-invasively in real time are helpful towards the development of successful cell transplantation techniques. Novel molecular imaging methods which are non-invasive particularly such as MRI have been of great recent interest. Hence, mouse models which are of clinical relevance have been studied by injecting contrast agents used for labelling cells such as super-paramagnetic iron-oxide (SPIO) nanoparticles for cellular imaging. The MR techniques which can be used to generate positive contrast images have been of much relevance recently for tracking of the labelled cells. Particularly when the off-resonance region in the vicinity of the labeled cells is selectively excited while suppressing the signals from the non-labeled regions by the method of spectral dephasing. Thus, tracking of magnetically labelled cells employing positive contrast in vivo MR imaging methods in a burn mouse model in a non-invasive way has been the scope of this study. The consequences have direct implications for monitoring labeled stem cells at some stage in wound healing. We suggest that our approach can be used in clinical trials in molecular and regenerative medicine.

关键词： Burn Wounds Cell Labeling Cell Tracking Cellular Imaging magnetic resonance Imaging (MRI) Molecular Imaging Positive Contrast Imaging Stem Cells

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Correlation between Carotid Plaque Characteristics without Operative Indication and Ischemic Stroke

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Chinese Journal of Biomedical Engineering(English Edition) 2020年第2期29卷 17-24页

作者： Qian Wang Sibo Liu Anni Long Jingzhe Liu Xiaowei Zhang Lei Li Department of Vascular Surgery the First Affiliated Hospital of Tsinghua UniversityBeijing 100016China Department of Radiology the First Affiliated Hospital of Tsinghua UniversityBeijing 100016China

Objective To access the correlations between characteristics of carotid plaque in MRI and ischemic stroke in patients with≤50%carotid artery *** A total of 43 patients with≤50%carotid artery stenosis were selected for ultrasound from September 2014 to February 2016.A further test using magnetic resonance(MR)black blood imaging examination were carried out to distinguish the anatomy of the vessel as well the composition of the atherosclerotic plaque with remarkable *** relationship between carotid plaque characteristics in MRI and other risk factors of patients with ischemic stroke was analyzed by univariate and multivariate *** The mean follow-up time was 11.8 *** the follow-up period,4 of the 43 individuals experienced an ipsilateral ischemic ***-Meier survival analysis showed the mean ischemic stroke free survival of patients with coronary heart disease(CHD)was significantly shorter than that in patients without CHD,which were 12.1 months and 18.7 months respectively(P=0.029).The mean ischemic stroke free survival of patients with intra-plaque hemorrhage(IPH)was significantly shorter than that in patients without IPH,which were 14.3 months and 18.6 months respectively(P=0.001).COX regression analysis showed that coronary heart disease(HR=27.4;95%CI,1.6-464.3;P=0.022)and IPH(HR=18.2;95%CI,2.7-123.3;P=0.003)were independent risk factors for ischemic *** For patients with carotid artery stenosis≤50%,IPH of carotid plaques and CHD are independent risk factors for ischemic stroke.

关键词： Carotid artery plaque Ischemic stroke Intra-plaque hemorrhage Coronary heart disease magnetic resonance

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Apoptosis in rat transient focal cerebral ischemic stroke:clinical implications

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中国临床神经科学 2000年第Z1期8卷 18-19页

作者： Shoushu Jiao Jue Wang Gal Hever Rongzheng Kuang Jean-Claude Louis Ella Magal Department of Neuroscience AmgenInc.One Amgen Center Dr.Thousand OaksCalifornia91320USA

In the early phase of cerebral ischemia,factors threatening neuronal survival in the penumbra include mainly glutamate excitotoxicity,free radical damage and energy failure resulting from recurrent depolarization ***,at later times,other mechanisms come into *** initial ischemic event activates a variety of genetic programs that unfold over the course of hours and *** positron emission tomography and magnetic resonance based techniques demonstrate that the development of irretrievable tissue damage is relatively slow,progressing over the course of several days in some cases,and a viable tissue,defined by hemodynamic and metabolic criteria,is still present many hours after stroke in human or in *** findings suggest that the brain can potentially be“rescued”from infarction many hours after onset of ischemia and challenge the widespread notion of an early and short“therapeutic window”(~3-6h).This realization is of critical importance for stroke therapy because most patients reach medical attention at a time when current therapeutic strategies may no longer be ***,it would be highly desirable to develop therapeutic interventions that can be instituted many hours after the onset of *** believe that addressing the mechanisms of delayed cell death is key to a successful *** studies presented here were designed to document the potential contribution of apoptosis to ischemia induced neuronal *** will discuss the morphological,biochemical and pharmacological evidence for apoptosis in the ischemic stroke.

关键词： positron emission tomography magnetic resonance cerebral ischemia ischemic stroke neuronal death cell death

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Small bowel imaging of inflammatory bowel disease

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World Journal of Radiology 2015年第8期7卷 198-201页

作者： Emanuele Casciani Chiara De Vincentiis Gianfranco Gualdi Department of Emergency Radiology "La Sapienza" University-Hospital Umberto I Department of Radiology "La Sapienza" University-Sant’Andrea’s Hospital

The study of the small bowel(SB) has always beenchallenging both for clinicians and radiologist. It is a long and tortuous tube that can be affected by various pathologies whose signs and symptoms are usually non specific and can mimic other acute abdominal disorders. For these reasons, imaging plays a central role in the diagnosis of the different pathological conditions that can occur. They are important also in the management and follow up of chronic diseases. We expose and evaluate all the radiological methods that are now available for the study of the SB with particular emphasis on the technological improvement of cross-sectional imaging, such as computed tomography(CT) and magnetic resonance imaging(MRI). These techniques have, infact, highly improved in terms of execution times(fast acquisitions images), patients discomfort and radiation dose, for CT, with consequent reduced biological risks. Moreover, the new post-processing options with multiplanar reconstruction and isotropic images have made significant changes in the evaluation of the exams. Especially MRI scans have been improved by the advent of new sequences, such as diffusion weighted imaging and cine-MRI, parallel imaging and breath-hold sequences and can provide excellent soft-tissue contrast without the use of ionizing radiations.

关键词： Small bowel imaging magnetic resonance Cross-sectional imaging Computed tomography Positron emission tomography-computed tomography

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The value of three dimensional brainvolum combined with time-of-flight MRA in microvascular decompression

The value of three dimensional brainvolum combined with time...

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第十六届中国医师协会神经外科医师年会

作者： Jun Li Ying Wang Zhigang Lian Rongyao Liu Zhanhua Liang Chunli Song Qingwei Song Zhenqing Wei Department of neurosurgery First Affiliated Hospital of Dalian Medical University Department of neurology First Affiliated Hospital of Dalian Medical University Department of radiology First Affiliated Hospital of Dalian Medical University

Objectives:To explore the guiding value of preoperative three dimensional brainvolume(3D-BRAVO) and three dimensional time-of-flight(3D-TOF) MRA scanning for microvascular ***:113 patients treated with microvascular decompression from February 2016 to February 2018 in the first affiliated hospital of Dalian medical university were retrospectively *** patients received 3D-BRAVO combined with 3D-TOF MRA sequence reconstruction before *** anatomical relationship of neurovascular was analyzed and compared with the results of intraoperative ***:The results of MVD showed that the number of positive cases is 108(95.6%) on the diseased side.3D-BRAVO combined with 3D-TOF sequence reconstruction showed positive 106 cases(93.8%) with 98.1% positive coincidence rate and 13.2% false positive rate,P<0.05.3D-BRAVO-TOF sequence reconstruction of trigeminal neuralgia showed positive coincidence rate 78 cases(92.8%) and hemifacial spasm is 27(93.1%).Conclusion:3D-BRAVO combined with 3DTOF sequence reconstruction before microvascular decompression can fully evaluate the morphology,location and anatomical relationship of the lesions,which is of guiding value for clinical diagnosis and treatment.

关键词： Microvascular decompression magnetic resonance 3D-BRAVO 3D-TOF

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语言区附近病变患者的功能磁共振神经导航手术的围手术期护理

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中国实用护理杂志 2009年第20期25卷 40-41页

作者：潘金玉鲜继淑第三军医大学附属西南医院

语言区附近病变的手术一直是神经外科的难点,如何做到既切除肿瘤又保留语言功能是提高手术疗效,减少手术副损伤的关键,语言区的准确定位是解决语言功能保留与病变切除程度之间矛盾的最有效的方法。我科自2004年5月开始应用功能磁共振(fu... 详细信息

语言区附近病变的手术一直是神经外科的难点,如何做到既切除肿瘤又保留语言功能是提高手术疗效,减少手术副损伤的关键,语言区的准确定位是解决语言功能保留与病变切除程度之间矛盾的最有效的方法。我科自2004年5月开始应用功能磁共振(functional magnetic resonance imaging,FMRI)进行语言区功能定位,在FMRI神经导航辅助下完成语言区附近病变手术65例,通过手术与术前、术中、术后的精心护理与配合取得了良好的手术疗效,现报道如下。

关键词：语言区病变切除患者功能磁共振神经导航手术 magnetic resonance 语言功能手术疗效现报道如下手术副损伤准确定位神经外科精心护理功能定位功能保留 FMRI 辅助下肿瘤术后矛盾

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Analysis and Maximum Efficiency Design for Wireless Power Transfer Systems

Analysis and Maximum Efficiency Design for Wireless Power Tr...

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第37届中国控制会议

作者： Bing Cao Hongbin Wang Qingyi Wang Min Ding Quan Yin School of Automation China University of Geosciences Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems State Grid Corporation of China School of Automation Huazhong University of science and technology

How to stabilize the output voltage while ensuring the maximum charging efficiency of the system is a problem faced by the development of wireless power transfer（WPT）. Especially in the dynamic environment, the change of system coupling coefficient or load resistance will have a huge impact on the system. In this paper, a two-stage DC-DC converter control mode is used to control the system with the goal of dynamic charging demand. Among them, the system achieves impedance matching through the receiver DC-DC converter to ensure the transmission efficiency of the system, and in order to match the impedance,the voltage and current information in the coil is used to calculate the coupling coefficient, then, the coupling coefficient can be used to achieve maximum efficiency. The system output voltage is stabilized by using the transmitter DC-DC converter. The simulation experiment shows that the control mode can stabilize the output voltage well, and is more efficient than the single receiver closed loop control（SRCLP） system.

关键词： Wireless Power Transfer magnetic resonance Efficiency Maximization

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基于钻石探针的单分子磁共振波谱新技术

基于钻石探针的单分子磁共振波谱新技术

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中国化学会-生物物理化学专业委员会第四届全国生物物理化学会议

作者：石发展 USTC

magnetic resonance(MR) is one of the most important techniques for characterizing compositions, structure and dynamics of these kind of materials. However, current methods need billions of uniform units on centimeter-scale to accumulate large enough signal-to-noise ratio. High sensitivity MR techniques are urgently needed for new applications on nanoscale. A sensor to accomplish nanoscale targets detection is the recently developed atomic sized magnetic field sensor based on the nitrogen-vacancy(NV) defect center in diamond. By combining the quantum controls and long coherence time of NV, we have experimentally realized nanoscale nuclear MR and electron spin resonance. In detail, we firstly realized detection of(5 nm)3 hydrogen nuclear spin sample including a few thousand atomic nuclei under ambient conditions, which is "a first step toward imaging complex molecular structures directly". Then we chose a nuclei dimer 13 C-13 C as a target and realized atomic-scale structure analysis of the dimer by measuring its coupling vector. Further, nuclear magnetic resoance spectroscopy with single spin sensitivity was accomplished. Recently, we have realized nanoscale microwave field imaging and even detection of single protein electron spin resonance spectroscopy. We not only recorded the single-protein magnetic resonance spectroscopy, but also inferred the motions of the protein by analysis the shape of spectra. These results, together with the relation works in the field, open a door to nanoscale MR and will be potentially used as a new tool on smart materials.

关键词： single molecule magnetic resonance

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