Apoptosis in rat transient focal cerebral ischemic stroke:clinical implications

作     者：Shoushu Jiao Jue Wang Gal Hever Rongzheng Kuang Jean-Claude Louis Ella Magal 

作者机构：Department of NeuroscienceAmgenInc.One Amgen Center Dr.Thousand OaksCalifornia91320USA 

出 版 物：《中国临床神经科学》 (Chinese Journal of Clinical Neurosciences)

年 卷 期：2000年第8卷第Z1期

页      面：18-19页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：positron emission tomography magnetic resonance cerebral ischemia ischemic stroke neuronal death cell death 

摘      要：In the early phase of cerebral ischemia,factors threatening neuronal survival in the penumbra include mainly glutamate excitotoxicity,free radical damage and energy failure resulting from recurrent depolarization ***,at later times,other mechanisms come into *** initial ischemic event activates a variety of genetic programs that unfold over the course of hours and *** positron emission tomography and magnetic resonance based techniques demonstrate that the development of irretrievable tissue damage is relatively slow,progressing over the course of several days in some cases,and a viable tissue,defined by hemodynamic and metabolic criteria,is still present many hours after stroke in human or in *** findings suggest that the brain can potentially be“rescuedfrom infarction many hours after onset of ischemia and challenge the widespread notion of an early and short“therapeutic window(~3-6h).This realization is of critical importance for stroke therapy because most patients reach medical attention at a time when current therapeutic strategies may no longer be ***,it would be highly desirable to develop therapeutic interventions that can be instituted many hours after the onset of *** believe that addressing the mechanisms of delayed cell death is key to a successful *** studies presented here were designed to document the potential contribution of apoptosis to ischemia induced neuronal *** will discuss the morphological,biochemical and pharmacological evidence for apoptosis in the ischemic stroke.