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Intelligent microneedle patch with prolonged local release of hydrogen and magnesium ions for diabetic wound healing

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Bioactive Materials 2023年第6期24卷 463-476页

作者： Pei Wang Jiayingzi Wu Haiyan Yang Hengke Liu Tianyu Yao Chang Liu Yan Gong Mingsong Wang Guangyu Ji Peng Huang Xiansong Wang Department of Thoracic Surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China Marshall Laboratory of Biomedical Engineering International Cancer CenterLaboratory of Evolutionary Theranostics(LET)School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen518060China Center of Hydrogen Science Shanghai Jiao Tong UniversityShanghai200240China

Diabetes mellitus,an epidemic with a rapidly increasing number of patients,always leads to delayed wound healing associated with consistent pro-inflammatory M1 polarization,decreased angiogenesis and increased reactive oxygen species(ROS)in the ***,a poly(lactic-co-glycolic acid)(PLGA)-based microneedle patch loaded with magnesium hydride(MgH_(2))(MN-MgH_(2))is manufactured for defeating diabetic *** application of microneedle patch contributes to the transdermal delivery and the prolonged release of MgH_(2) that can generate hydrogen(H_(2))and magnesium ions(Mg^(2+))after reaction with body *** released H_(2) reduces the production of ROS,transforming the pathological microenvironment induced by diabetes ***,the released Mg^(2+)promotes the polarization of pro-healing M2 ***,cell proliferation and migration are improved,and angiogenesis and tissue regeneration are *** intelligent microneedle patch provides a novel way for accelerating wound healing through steadily preserving and releasing of H_(2) and Mg^(2+)locally and sustainably.

关键词： Microneedle patch magnesium hydride Hydrogen magnesium ion Diabetic wound healing

The Earliest Discovery of the Role of magnesium ions on Stabilizing the Tertiary Structure of the Transfer RNA and Its Biological Significance —A Short Memoir

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Advances in Biological Chemistry 2016年第5期6卷 147-151页

作者： Wangyi Liu Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences The Chinese Academy of Sciences Shanghai China

In early of 1960s, I was a graduate student studying on tRNA biochemistry. In the course of the research, the magnesium ions stabilized the tertiary structure of tRNA, resulting in its resistance to enzymatic degradation was discovered independently. The experiment of deaminated (denatured) tRNA obtained from native tRNA was designed and conducted and further proved the validity of this finding. It was found that magnesium ions could stabilize the tertiary structure of the natrive tRNA but could not stabilize structure of the deaminated tRNA. In term of the methodology, this stabilization technique has been widely applied in sequencing analysis of RNA and has greatly promoted the progress in the study of primary structure of RNA. More importantly, the stabilization of the tertiary structure of RNA by magnesium ions plays a key role both in the processing of messenger RNAs and the ribozyme activity. After our first article in Chinese was published in 1963, a paper of Nishimura & Novelli came into our note. The received date of their paper was March 22 of 1963, only 4 days earlier than that of our first paper. Thus, we and Nishimura & Novelli made almost at the same time the earliest discovery of the role of magnesium ions on stabilizing the tertiary structure of the transfer RNA and thus resulted in resistance of tRNA degradation by enzymes. However, this discovery was not initially appreciated for a period of time but was finally “visualized” and proved by X-ray crystal structure of yeast phenylalanine tRNA, which has provided more accurate information on the geometry of the magnesium-binding sites in tRNA.

关键词： Deaminated tRNA Earliest Discovery Enzymatic Degradation magnesium ion Tertiary Structure Transfer RNA

Effect of magnesium on the C-S-H Nanostructure Evolution and Aluminate Phases Transition in Cement-Slag Blend

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Journal of Wuhan University of Technology(Materials Science) 2018年第1期33卷 108-116页

作者：丁庆军 YANG Jun 张高展 HOU Dongshuai School of Materials Science and Engineering Wuhan University of Technology Advanced Building Materials Key Laboratory of Anhui Province Anhui Jianzhu University Department of Civil Engineering Qingdao Technological University

The microstructural study was conducted on cement and cement-slag pastes immersed in different concentrations of Mg（NO3）2 solutions utilizing ^29Si, ^27Al NMR spectroscopy and XRD techniques. The results show that the hydration of both the cement and cement-slag pastes is delayed when the pastes are cured in Mg（NO3）2 solutions as compared to the pastes cured in water. Moreover, Mg^2＋ ions also exhibit an decalcifying and dealuminizing effect on the C-A-S-H in cement and cement-slag pastes, and thereby decrease Ca/Si and Al[4]/Si ratios of the C-A-S-H. The dealuminization of C-A-S-H is mitigated for cement-slag paste as compared to pure cement paste. The depolymerized calcium and aluminum ions from C-A-S-H gel mainly enter the pore solution to maintain the pH value and form Al^[6] in TAH, respectively. On the other hand, Mg^2＋ ions exert an impact on the intra-transition between Al^[6] species, from AFm and hydrogarnet to hydrotalcite-like phase. NO3^-ions are interstratified in the layered Mg-Al structure and formed nitrated hydrotalcite-like phase（Mg1-xAlx（OH）2（NO3）x·nH2O）. Results from both ^27Al NMR and XRD data show that ettringite seems not to react with Mg^2＋ ions.

关键词： ^29Si and ^27Al NMR magnesium ion C-A-S-H microstructure aluminate phases transition hydration slag incorporation

Stepwise 3D-spatio-temporal magnesium cationic niche: Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification

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Bioactive Materials 2021年第2期6卷 503-519页

作者： Jie Shen Bo Chen Xinyun Zhai Wei Qiao Shuilin Wu Xuanyong Liu Ying Zhao Changshun Ruan Haobo Pan Paul K.Chu Kenneth M.C.Cheung Kelvin W.K.Yeung Department of Orthopaedics and Traumatology The University of Hong KongHong KongChina Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma Department of Orthopaedics and Traumatologythe University of Hong Kong-Shenzhen HospitalShenzhenChina Shanghai Institute of Traumatology and Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesRuijin HospitalSchool of MedicineShanghai Jiaotong UniversityShanghaiChina School of Materials Science and Engineering Nankai UniversityTianjinChina School of Materials Science&Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjinChina Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials Science&EngineeringHubei UniversityWuhanChina State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghaiChina Cixi Center of Biomaterials Surface Engineering Shanghai Institute of CeramicsChinese Academy of SciencesNingboChina Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenChina Department of Physics Department of Materials Science&Engineeringand Department of Biomedical EngineeringCity University of Hong KongHong KongChina

The fate of cells and subsequent bone regeneration is highly correlated with temporospatial coordination of chemical,biological,or physical cues within a local tissue *** understanding of how mammalian cells react to local tissue microenvironment is paramount important when designing next generation of biomaterials for tissue *** study aims to investigate that the regulation of magnesium cationic(Mg^2+)tissue microenvironment is able to convince early-stage bone regeneration and its mechanism undergoes intramembranous *** was discovered that moderate Mg^2+content niche(~4.11 mM)led to superior bone regeneration,while Mg^2+-free and strong Mg^2+content(~16.44 mM)discouraged cell adhesion,proliferation and osteogenic differentiation,thereby bone formation was rarely *** magnesium ions diffused into free Mg zone from concentrated zone in late time point,new bone formation on free Mg zone became significant through intramembranous *** study successfully demonstrates that magnesium cationic microenvironment serves as an effective biochemical cue and is able to modulate the process of bony tissue *** knowledge of how a Mg^2+cationic microenvironment intertwines with cells and subsequent bone formation gained from this study may provide a new insight to develop the next generation of tissuerepairing biomaterials.

关键词： Nanocomposite magnesium ion Microenvironment 3D scaffold Bone tissue regeneration

Potassium ion pre‑intercalated MnO_(2)for aqueous multivalent ion batteries

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Frontiers of Optoelectronics 2023年第4期16卷 81-89页

作者： Zikang Xu Ruiqi Ren Hang Ren Jingyuan Zhang Jinyao Yang Jiawen Qiu Yizhou Zhang Guoyin Zhu Liang Huang Shengyang Dong School of Environmental Science and Engineering School of Chemistry and Materials ScienceNanjing University of Information Science and TechnologyNanjing 210044China Wuhan National Laboratory for Optoelectronics School of Optical and Electronic InformationHuazhong University of Science and TechnologyWuhan 430074China

Manganese dioxide(MnO_(2)),as a cathode material for multivalent ion(such as Mg^(2+)and Al^(3+))storage,is investigated due to its high initial ***,during multivalent ion insertion/extraction,the crystal structure of MnO_(2)partially collapses,leading to fast capacity decay in few charge/discharge ***,through pre-intercalating potassium-ion(K+)intoδ-MnO_(2),we synthesize a potassium ion pre-intercalated MnO_(2),K_(0.21)MnO_(2)·0.31H_(2)O(KMO),as a reliable cathode material for multivalent ion *** as-prepared KMO exhibits a high reversible capacity of 185 mAh/g at 1 A/g,with considerable rate performance and improved cycling stability in 1 mol/L MgSO_(4)*** addition,we observe that aluminum-ion(Al^(3+))can also insert into a KMO *** work provides a valid method for modifcation of manganesebased oxides for aqueous multivalent ion batteries.

关键词： Aqueous batteries Multivalent ion batteries magnesium ion Aluminum ion MnO_(2)

Fabrication of magnesium-doped porous polylactic acid microsphere for bone regeneration

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Biomaterials Translational 2023年第4期4卷 280-290页

作者： Ziwei Tao Ziyang Yuan Dong Zhou Lang Qin Lan Xiao Shihao Zhang Changsheng Liu Jinzhong Zhao Yulin Li Engineering Research Centre for Biomedical Materials of Ministry of Education Key Laboratory for Ultrafine Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghaiChina Department of Sports Medicine Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina School of Chemistry and Chemical Engineering Nanchang UniversityNanchangJiangxi ProvinceChina School of Mechanical Medical and Process EngineeringCenter of Biomedical TechnologyQueensland University of TechnologyBrisbaneAustralia Wenzhou Institute of Shanghai University WenzhouZhejiang ProvinceChina

Biodegradable polymer microspheres that can be used as drug carriers are of great importance in biomedical applications,however,there are still challenges in controllable preparation of microsphere surface morphology and improvement of *** this paper,firstly,poly(L-lactic acid)(PLLA)was synthesised by ring-opening polymerisation under anhydrous anaerobic conditions and further combined with the emulsion method,biodegradable PLLA microspheres(PM)with sizes ranging from 60-100μm and with good sphericity were *** addition,to further improve the surface morphology of PLLA microspheres and enhance their bioactivity,functionalised porous PLLA microspheres loaded with magnesium oxide(MgO)/magnesium carbonate(MgCO_(3))(PMg)were also prepared by the emulsion *** results showed that the loading of MgO/MgCO_(3)resulted in the formation of a porous structure on the surface of the microspheres(PMg)and the dissolved Mg^(2+)could be released slowly during the degradation of *** vitro cellular experiments demonstrated the good biocompatibility of PM and PMg,while the released Mg^(2+)further enhanced the anti-inflammatory effect and osteogenic activity of *** PMg not only show promise for controlled preparation of drug carriers,but also have translational potential for bone regeneration.

关键词： magnesium ion osteogenesis polylactic acid porous microspheres

Cations stress on low-grade nickel sulfide ore oxidation leaching

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Journal of Central South University 2020年第11期27卷 3278-3289页

作者： KANG Jin-xing WANG Xin WANG Ya-yun LIU Zhao-bo HAN Guo-qiang LIU Zhi-guo WANG Chuan-long ENFI Research Institute China ENFI Engineering Co.Beijing 100038China

The effects of cations stress of magnesium ion and sodium ion on the low-grade nickel sulfide ore oxidative leaching in simulated sulfuric acid solutions were *** study was performed in two courses,including the effect of the cations on the valuable metals leaching efficiencies of the nickel ore and its influences on the electrochemical oxidation behavior of the nickel *** leaching results present that parts of magnesium-containing gangues and ferrous sulfide are preferentially dissolved into lixivium,and the leaching efficiencies of Ni and Cu decreased much related to the leached concentrations of Mg^2+*** results of electrochemical measurements show that the oxidation leaching of the low-grade nickel sulfide ore is controlled by the intermediates oxidative ***^2+,as well as Na^+,affects the transformations of the Fe^3+/Fe^2+ couple and sulfur-containing species,and those cations are apt to be attracted by the anions and directionally adhere to the negative active site of the metal sulfide surface,causing an increase in the electrochemical activities,which facilitates the electron transfer between the ore and leaching *** comparative study of the role of Mg^2+ and Na^+,it is found that Mg^2+ negatively affects the oxidative diffusion of the intermediates through promoting the generation of a compact film,which lowers the metals leached efficiencies,and the unfavorable effect of Na+tends to be the coupled effect of the leached Mg^2+ and Fe^3+.

关键词： magnesium ion sodium ion intermediates diffusion directional adsorption passivation film

Changes of calcitonin gene-related peptide and other serological indicators in vestibular migraine patients

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Frigid Zone Medicine 2021年第2期1卷 111-118页

作者： Xinyi Liu Yonghui Pan Jingjing Wang Lei Zhang Junli Zhang The First Affiliated Hospital of Harbin Medical University Harbin 150001China The First People's Hospital of Shangqiu Shangqiu 476005China

Objective:It aims to evaluate the diagnostic ability of CGRP and other blood indicators in vestibular migraine(VM)patients,and to explain the potential pathological effects of these *** hypothesis of VM being a variant of migraine was ***:A total of 32 VM patients,35 migraine patients,and 30 healthy control subjects(HC)were selected for this cross-sectional *** statistics on demographic data,clinical manifestations,calcitonin gene-related peptide(CGRP)and common clinical laboratory indicators were measured within 24 hours from the onset of the *** operating characteristic(ROC)curve and area under the curve(AUC)were analyzed for *** risk factors of VM and migraine were determined through univariate and multivariate ***:Compared with HC,serum CGRP levels(p(VM)=0.012,p(Migraine)=0.028)increased and Mg^(2+)levels(p(VM)ion,VM was correlated with CGRP[odds ratio(OR)=1.07;95%confidence interval(CI),1.02-1.12;P=0.01]and Mg^(2+)[odds ratio(OR)=0.03;95%CI,0.07-0.15;Pion between VM and migraine groups,with AUC of 0.649(95%CI,0.518 to 0.780).The optimal threshold for Mg^(2+)to diagnose VM was ***:This study demonstrated that CGRP and Mg^(2+)may be promising laboratory indicators to discriminate HC from VM/migraine,while Mg^(2+)may be uded as a discriminator between VM and migraine.

关键词： calcitonin gene-related peptide vestibular migraine magnesium ion trigeminovascular system

Extraction Thermodynamics of magnesium from the high ration of magnesium and lithium in Salt Lake Brines

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Extraction Thermodynamics of Magnesium from the high ration ...