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CD36 expression and lipid metabolism following an oral glucose challenge in South Asians

World Journal of Diabetes 2015年第7期6卷 983-989页

作者： Jeetesh V Patel Amitava Banerjee Silvia Montoro-Garcia Eduard Shantsila Mushfique Alam Paul Flinders Kathleen AL Houlton Elizabeth A Hughes Gregory YH Lip Paramjit S Gill University of Birmingham Centre for Cardiovascular Sciences Sandwell and West Birmingham Hospitals NHS Trust Sandwell Medical Research Unit Sandwell General Hospital Primary Care Clinical Sciences University of Birmingham Medical School University of Nottingham

AIM:To investigate lipid metabolism and the relationship with monocyte expression of the fatty acid translocase CD36 in South ***:An observational study of South Asians whom as an ethnic group have-a higher risk of developing *** susceptibility to diabetes is coupled with an earlier and more rapid progression of micro-,and macro-vascular *** healthy South Asian participants [mean age 34.6(8.9) years,76.2% male,mean body-mass index 25.0(5.2) kg/m2] were recruited from an urban residential area of central Birmingham(United Kingdom).The main outcomes measured were post prandial(30 min) and post absorptive(120 min) changes from fasting(0 min) in circulating lipoproteins,lipds and hormones,andmonocyte expression of CD36 post injection of a 75 g oral glucose *** inducements of variations of monocyte CD36 expression were ***:Our results showed evident changes in monocyte CD36 expression following the glucose challenge(P < 0.001).Non-esterified fatty acids(NEFA) levels decreased progressively during the challenge(P < 0.001),in contrast to increased cholesterol(but not triglyceride) concentrations within very low density lipoprotein(VLDL) and low density lipoprotein subfractions(P < 0.01).Levels of,glucose,serum triglycerides and high density lipoprotein cholesterol remained largely *** of monocyte CD36 were negatively(r =-0.47,P = 0.04) associated to fat from the diet and positively to carbohydrate from the diet(r = 0.65,P < 0.001).CONCLUSION:These data suggest that the initiation of VLDL genesis follows the consumption of glucose within this population,inferring that the sequestration of NEFA from these particles happens due to the increased availability of CD36 *** these are preliminary results,it would appear that lifestyle exposures have a role in moderating the expression of CD36.

关键词： CD36 Lipoprotein Glucose South Asians Diabetes Micro-vascular macro-vascular

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