CD36 expression and lipid metabolism following an oral glucose challenge in South Asians

作     者：Jeetesh V Patel Amitava Banerjee Silvia Montoro-Garcia Eduard Shantsila Mushfique Alam Paul Flinders Kathleen AL Houlton Elizabeth A Hughes Gregory YH Lip Paramjit S Gill 

作者机构：University of Birmingham Centre for Cardiovascular SciencesSandwell and West Birmingham Hospitals NHS Trust Sandwell Medical Research UnitSandwell General Hospital Primary Care Clinical SciencesUniversity of Birmingham Medical SchoolUniversity of Nottingham 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2015年第6卷第7期

页      面：983-989页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：The British Heart Foundation(Project Grant Award:PG PG/08/014) A postdoctoral research grant from the Fundación Ramón Areces(Spain)(to Dr.Montoro-Garcia S) 

主　　题：CD36 Lipoprotein Glucose South Asians Diabetes Micro-vascular Macro-vascular 

摘      要：AIM:To investigate lipid metabolism and the relationship with monocyte expression of the fatty acid translocase CD36 in South ***:An observational study of South Asians whom as an ethnic group have-a higher risk of developing *** susceptibility to diabetes is coupled with an earlier and more rapid progression of micro-,and macro-vascular *** healthy South Asian participants [mean age 34.6(8.9) years,76.2% male,mean body-mass index 25.0(5.2) kg/m2] were recruited from an urban residential area of central Birmingham(United Kingdom).The main outcomes measured were post prandial(30 min) and post absorptive(120 min) changes from fasting(0 min) in circulating lipoproteins,lipds and hormones,andmonocyte expression of CD36 post injection of a 75 g oral glucose *** inducements of variations of monocyte CD36 expression were ***:Our results showed evident changes in monocyte CD36 expression following the glucose challenge(P 0.001).Non-esterified fatty acids(NEFA) levels decreased progressively during the challenge(P 0.001),in contrast to increased cholesterol(but not triglyceride) concentrations within very low density lipoprotein(VLDL) and low density lipoprotein subfractions(P 0.01).Levels of,glucose,serum triglycerides and high density lipoprotein cholesterol remained largely *** of monocyte CD36 were negatively(r =-0.47,P = 0.04) associated to fat from the diet and positively to carbohydrate from the diet(r = 0.65,P 0.001).CONCLUSION:These data suggest that the initiation of VLDL genesis follows the consumption of glucose within this population,inferring that the sequestration of NEFA from these particles happens due to the increased availability of CD36 *** these are preliminary results,it would appear that lifestyle exposures have a role in moderating the expression of CD36.