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Effectivenss of electroacupuncture for skeletal muscle pain in Parkinson's disease:a Clinical randomized controlled trial

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Journal of Traditional Chinese Medicine 2024年第2期44卷 388-395页

作者： WANG Shaosong SUN Jingqing FENG Qingyin LI Bin WANG Xin YUAN Fan CUI Yingxue Department of acupuncture Beijing Hospital of Traditional Chinese MedicineBeijing 100010China

OBJECTIVE:To explore the effect of electroacupuncture on skeletal muscle pain in Parkinson's disease(PD).METHODS:A single-center randomized controlled trial was conducted with sixty patients with Parkinson's disease with skeletal muscle pain were randomly divided into electroacupuncture group and sham acupuncture control group with 30 patients each.The electric acupuncture group was treated with electric acupuncture,while the control group was treated with Park needle pseudoacupuncture.Both groups were treated 5 times a week for a total of 4 weeks,and both groups completed 20 treatments.King's Parkinson's Pain Scale(KPPS)and visual analog scale(VAS)were used before and after treatment to evaluate the pain degree of patients.Realtime shear wave elastography(SWE)and modified Ashworth score(MAS)were used to evaluate the changes of muscle tone.Parkinson's comprehensive Score Scale(MDS-UPDRS,including UPDRS Ⅱ and UPDRS Ⅲ)was used to evaluate exercise ability.Hamilton Depression Scale(HAMD)score was used to evaluate the emotional changes of patients.Spearman correlation analysis was used to explore the correlation between pain degree and muscle tone,exercise ability and emotion.RESULTS:During the study,one case fell off in the control group,and 30 cases were eventually included in the analysis and treatment group and 29 cases in the control group.After treatment,Young's modulus of biceps and quadriceps and shear wave velocity of biceps were decreased in electroacupuncture group compared with before treatment,while KPPS score,VAS score,UPDRS Ⅱ,UPDRS Ⅲ and modified Ashworth score were decreased,with statistical significance(P0.05).After treatment,KPPS score,VAS score,UPDRS Ⅱ and UPDRS Ⅲ,MAS,HAMD score,Young's modulus of biceps and shear wave velocity in electroacupuncture group were significantly lower than those in control group(P<0.05).Spearman correlation analysis showed that KPPS score was positively correlated with UPDRS Ⅲ(r=0.414,P<0.05).KPPS score was

关键词： Parkinson disease muscle skeletal pain electroacupuncture muscle tention mood disorders randomized controlled trial

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Alternative relay regulates the adenosine triphosphatase activity of Locusta migratoria striated muscle myosin

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Insect Science 2024年第2期31卷 435-447页

作者： Jie Hao Chang Liu Ning Zhang Jing Li Tong Ni Mingbo Qu Xiang-dong Li State Key Laboratory oflntegrated Management of lnsect Pests and Rodents Insttute of ZoologyChinese Academy of SciencesBejingChina University of Chinese Academy of Sciences BejingChina School of Bioengeering Dalian University of TechnologyDalianChina

Locust(Locusta migratoria)has a single striated muscle myosin heavy chain(Mhc)gene,which contains 5 clusters of alternative exclusive exons and 1 differently included penultimate exon.The alternative exons of Mhc gene encode 4 distinct regions in the myosin motor domain,that is,the N-terminal SH3-like domain,one lip of the nucleotide-binding pocket,the relay,and the converter.Here,we investigated the role of the alternative regions on the motor function of locust muscle myosin.Using Sf9-baculovirus protein expression system,we expressed and purified 5 isoforms of the locust muscle myosin heavy meromyosin(HMM),including the major isoform in the thorax dorsal longitudinal flight muscle(FL1)and 4 isoforms expressed in the abdominal intersegmental muscle(AB1 to AB4).Among these 5 HMMs,FL1-HMM displayed the highest level of actin-activated adenosine triphosphatase(ATPase)activity(hereafter referred as ATPase activity).To identify the alternative region(s)responsible for the elevated ATPase activity of FL1-HMM,we produced a number of chimeras of FL1-HMM and AB4-HMM.Substitution with the relay of AB4-HMM(encoded by exon-14c)substantially decreased the ATPase activity of FL1-HMM,and conversely,the relay of FL1-HMM(encoded by exon-14a)enhanced the ATPase activity of AB4-HMM.Mutagenesis showed that the exon-14a-encoded residues Gly474 and Asn509 are responsible for the elevated ATPase activity of FL1-HMM.Those results indicate that the alternative relay encoded by exon-14a/c play a key role in regulating the ATPase activity of FL1-HMM and AB4-HMM.

关键词： alternative splicing ATPase Locusta migratoria molecular motor muscle myosin

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An atlas of expression quantitative trait loci of microRNAs in longissimus muscle of eight-way crossbred pigs

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Journal of Genetics and Genomics 2023年第6期50卷 398-409页

作者： Liepeng Zhong Min Zheng Yizhong Huang Tao Jiang Bin Yang Lusheng Huang Junwu Ma State Key Laboratory for Pig Genetic Improvement and Production Technology Jiangxi Agricultural UniversityNanchangJiangxi 330045China

MicroRNAs(miRNAs)are key regulators of myocyte development and traits,yet insight into the genetic basis of variation in miRNA expression is still limited.Here,we present a systematic analysis of expression quantitative trait loci(eQTL)for miRNA profiling in longissimus muscle of pigs from an eight-breed crossed heterogeneous population.By integrating the whole-genome sequencing and miRNAomics data,we map 54 cis-and 292 trans-e QTLs at high resolution that are associated with the expression of 54 and 92miRNAs,respectively.Twenty-three trans-acting loci are identified to affect the expression of nine myomi Rs(known muscle-specific miRNAs).MiRNAs in mammalian conserved miRNA clusters are found to be subjected to regulation by shared cis-e QTLs,while the expression of mature miRNA-5p/-3p counterparts is more likely to be regulated by different cis-e QTLs.Fine mapping and bioinformatics analyses pinpoint the peak cis-e SNP of mi R-4331-5p,rs344650810,which is located in its seed region,as a causal variant for the changes in expression and function of this miRNA.Additionally,rs344650810 is significantly(Pmuscle fibers.Altogether,this study provides a comprehensive atlas of miRNA-e QTLs in porcine skeletal muscle and new insights into regulatory mechanisms of miRNA expression.

关键词： miRNA eQTL Pig muscle Causal variant Regulatorymechanism

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MicroRNA is a potential target for therapies to improve the physiological function of skeletal muscle after trauma

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Neural Regeneration Research 2022年第7期17卷 1617-1622页

作者： Xin-Yi Gu Bo Jin Zhi-Dan Qi Xiao-Feng Yin Department of Orthopedics and Traumatology Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) BeijingChina Department of Orthopedics The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu ProvinceChina

MicroRNAs can regulate the function of ion channels in many organs.Based on our previous study we propose that miR-142a-39,which is highly expressed in denervated skeletal muscle,might affect cell excitability through similar mechanisms.In this study,we overexpressed or knocked down miR-142a-3p in C2C12 cells using a lentivirus method.After 7 days of differentiation culture,whole-cell currents were recorded.The results showed that overexpression of miR-142a-3p reduced the cell membrane capacitance,increased potassium current density and decreased calcium current density.Knockdown of miR-142a-3p reduced sodium ion channel current density.The results showed that change in miR-142a-3p expression affected the ion channel currents in C2C12 cells,suggesting its possible roles in muscle cell electrophysiology.This study was approved by the Animal Ethics Committee of Peking University in July 2020(approval No.LA2017128).

关键词： C2C12 denervation ion channels microRNA miR-142a-3p muscle patch clamp potassium sodium whole-cell currents

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Associations of muscle mass,strength,and quality with all-cause mortality in China:a population-based cohort study

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Chinese Medical Journal 2022年第11期135卷 1358-1368页

作者： Man Wu Yuxia Wei Jun Lv Yu Guo Pei Pei Jiachen Li Huaidong Du Ling Yang Yiping Chen Xiaohui Sun Hua Zhang Junshi Chen Zhengming Chen Canqing Yu Liming Li 无 Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Key Laboratory of Molecular Cardiovascular Sciences Ministry of EducationPeking UniversityBeijing 100191China Peking University Center for Public Health and Epidemic Preparedness&Responses Beijing 100191China National Coordinating Center of China Kadoorie Biobank Chinese Academy of Medical SciencesBeijing 102308China Medical Research Council Population Health Research Unit the University of OxfordOxford OX37LFUK Clinical Trial Service Unit and Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxford OX37LFUK NCDs Prevention and Control Department Qingdao CDCQingdaoShandong 266033China NHC Key Laboratory of Food Safety Risk Assessment China National Center for Food Safety Risk AssessmentBeijing 100022China. on behalf of the China Kadoorie Biobank Collaborative Group

Background It remains unclear about the association of muscle mass,strength,and quality with death in the general Chinese population of diverse economical and geographical backgrounds.The present study aimed to comprehensively examine such associations across different regions in China.Methods Based on the China Kadoorie Biobank study,the present study included 23,290 participants who were aged 38 to 88 years and had no prevalent cardiovascular diseases or cancer.muscle mass and grip strength were measured using calibrated instruments.Arm muscle quality was defined as the ratio of grip strength to arm muscle mass.Low muscle mass,grip strength,and arm muscle quality were defined as the sex-specific lowest quintiles of muscle mass index,grip strength,and arm muscle quality,respectively.Cox proportional hazards models yielded hazard ratios(HRs)and 95%confidence intervals(CIs)for risks of all-cause mortality in relation to muscle mass,strength,and quality.Results During a median follow-up of 3.98 years,739 participants died.The HR(95%CI)of all-cause mortality risk was 1.28(1.08–1.51)for low appendicular muscle mass index,1.38(1.16–1.62)for low total muscle mass index,1.68(1.41–2.00)for low grip strength,and 1.41(1.20–1.66)for low arm muscle quality in models adjusted for sociodemographic characteristics,lifestyle factors,and medical histories.Conclusion Low muscle mass,grip strength,and arm muscle quality are all associated with short-term increased risks of mortality,indicating the importance of maintaining normal muscle mass,strength,and quality for general Chinese adults.

关键词： muscle All-cause mortality Chinese Prospective muscle mass muscle strength muscle quality

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Maternal organic selenium supplementation during gestation enhances muscle fiber area and muscle fiber maturation of offspring in porcine model

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Journal of Animal Science and Biotechnology 2023年第2期14卷 654-665页

作者： Yan Lin Hui Yan Lei Cao Daolin Mou Dajiang Ding Binting Qin Lianqiang Che Zhengfeng Fang Shengyu Xu Yong Zhuo Jian Li Jianping Wang Chao Huang Yuanfeng Zou Lixia Li De Wu Bin Feng Animal Nutrition Institute Sichuan Agricultural UniversityChengduChina Key Laboratory of Animal Disease‑Resistant Nutrition of Ministry of Education Sichuan Agricultural UniversityChengduChina College of Veterinary Medicine Sichuan Agricultural UniversityChengdu 611130SichuanChina

Background:Organic selenium supplementation during gestation improves the antioxidant status and reproduc-tive performance of sows and increases the antioxidative capacity of the intestines of their offspring.This study was conducted to investigate the effect of maternal basel diet(control)supplemented with an organic Se,2-hydroxy-4-methylselenobutanoic acid(HMSeBA),or inorganic sodium selenite(Na_(2)SeO_(3))during gestation on the antioxidant status and development of muscle in newborn and weaned piglets.Newborn piglets before colostrum intake and weaned piglets were selected for longissimus dorsi(LD)muscle collection and analysis.Results:The results showed that maternal HMSeBA supplementation increased the muscle area and content of Se in the LD muscle of newborn piglets,improved gene expression of selenoproteins,and decreased oxidative status in the LD muscle of both newborn and weaned piglets compared with the control.The expression of muscle development-related genes of newborn piglets in the HMSeBA group was lower than in the control group,whereas the expression of MRF4 in weaned piglets was higher in the HMSeBA group than in the control and Na_(2)SeO_(3)groups.In addition,HMSeBA supplementation decreased the mRNA expressions of myosin heavy chains(MyHC)IIx and MyHC IIb and the percentage of MyHC IIb;increased the expression of PGC-1αin the LD muscle of newborn piglets;increased the gene expression of MyHC IIa;and decreased the protein expression of slow MyHC and the activity of malate dehydrogenase in the LD muscle of weaned piglets compared with the control group.Conclusions:Maternal HMSeBA supplementation during gestation can improve the antioxidative capacity of the muscle of their offspring and promote the maturity of muscle fibres in weaned offspring.

关键词： Antioxidation HMSeBA muscle Offspring Sows

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Vitamin A injection at birth improves muscle growth in lambs

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Animal Nutrition 2023年第3期14卷 204-212页

作者： Pengkang Song Xiaoyou Chen Jiamin Zhao Qiang Li Xinrui Li Yu Wang Bo Wang Junxing Zhao College of Animal Science Shanxi Agricultural UniversityTaiguShanxi030801China State Key Laboratory of Animal Nutrition Department of Animal Nutrition and Feed ScienceCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing100193China

Vitamin A and its metabolite,retinoic acid(RA)play important roles in regulating skeletal muscle development.This study was conducted to investigate the effects of early intramuscular vitamin A injection on the muscle growth of lambs.A total of 16 newborn lambs were given weekly intramuscular injections of corn oil(control group,n=8)or 7,500 IU vitamin A palmitate(vitamin A group,n=8)from birth to 3 wk of age(4 shots in total).At 3 wk of age and weaning,biceps femoris muscle samples were taken to analyze the effects of vitamin A on the myogenic capacity of skeletal muscle cells.All lambs were slaughtered at 8 months of age.The results suggest that vitamin A treatment accelerated the growth rate of lambs and increased the loin eye area(Pmuscle(P0.05).Moreover,vitamin A upregulated the expression of PAX7(Pmuscle-derived mononuclear cells from vitamin A-treated lambs showed higher expression of myogenic genes(Pmuscle-derived mononuclear cells in the first 3 d(P0.05)as evidenced by myogenic gene expression and fusion index.Taken together,neonatal intramuscular vitamin A injection promotes lamb muscle growth by promoting the myogenic potential of satellite cells.

关键词： Vitamin A Lamb muscle Retinoic acid Myogenesis Satellite cell

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Improving the prognosis before and after liver transplantation:Is muscle a game changer?

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World Journal of Gastroenterology 2022年第40期28卷 5807-5817页

作者： Alexis Goffaux Alicia Delorme Géraldine Dahlqvist Nicolas Lanthier Laboratory of Hepato-Gastroenterology Institut de Recherche Expérimentale et CliniqueUniversitécatholique de LouvainBrussels 1200Belgium Service d’Hépato-Gastroentérologie Cliniques universitaires Saint-LucUniversitécatholique de LouvainBrussels 1200Belgium

Liver transplantation(LT)is currently the only curative treatment option for selected patients with end stage liver disease or hepatocellular carcinoma.Improving waiting list-mortality,post-transplant morbidity and mortality and refining the selection of the patients remain our current central objectives.In this field,different concepts dealing with nutrition and the muscle such as sarcopenia,malnutrition,frailty or myosteatosis have emerged as possible game changers.For more than a decade,many prospective studies have demonstrated that sarcopenia and frailty are major predictive factors of mortality in the waiting list but also after LT.Malnutrition is also a well-known risk factor for morbidity and mortality.muscle composition is a newer concept giving insight on muscle quality which has also been shown to be linked to poorer outcomes.Each of these terms has a precise definition as well as pathophysiological mechanisms.The bidirectional liver-muscle axis makes sense in this situation.Defining the best,easy to use in clinical practice tools to assess muscle quality,quantity,and function in this specific population and developing quality prospective studies to identify interventional strategies that could improve these parameters as well as evaluate the effect on mortality are among the important challenges of today.

关键词： muscle Liver Transplantation Sarcopenia Myosteatosis Frailty

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Effectiveness and safety of subthreshold vibration over suprathreshold vibration in treatment of muscle fatigue in elderly people

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World Journal of Clinical Cases 2023年第15期11卷 3434-3443页

作者： Ayman A Mohamed Esra Khaled Asma Hesham Ahmed Khalf Physical Therapy Nahda UniversityBeni Suef 23435Egypt Physical Therapy Beni-Suef UniversityBeni Suef 32456Egypt

muscle fatigue is common in many populations,particularly elderlies.Aging increases the incidence of muscle fatigue and delays its recovery.There is a huge debate about the current treatments for muscle fatigue,particularly in elderlies.Recently,it has been discovered that mechanoreceptors have an important role as a sensory system in sensing muscle fatigue which could enhance the body's response to muscle fatigue.The function of mechanoreceptors could be enhanced by applying either suprathreshold or subthreshold vibration.Although suprathreshold vibration improves muscle fatigue,it can cause desensitization of cutaneous receptors,discomfort,and paresthesia,which are barriers to clinical use.Subthreshold vibration has been approved as a safe and effective method of training for mechanoreceptors;however,its use and effectiveness in muscle fatigue have never been tested or explained.Possible physiological effects of subthreshold vibration in the treatment of muscle fatigue include:(1)Enhancing the function of mechanoreceptors themselves;(2)Increasing the firing rate and function of alpha motor neurons;(3)Increasing blood flow to fatigued muscles;(4)Decreasing the rate of muscle cell death in elderlies(sarcopenia);and(5)Driving motor commands and allow better performance of muscles to decrease fatigue incidence.In conclusion,the use of subthreshold vibration could be a safe and effective treatment for muscle fatigue in elderlies.It could enhance recovery from muscle fatigue.Finally,Subthreshold Vibration is safe and effective in treating muscle fatigue in comparison to suprathreshold vibration.

关键词： Subthreshold Vibration muscle Fatigue Elderly people

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Micro RNA transcriptome of skeletal muscle during yak development reveals that miR-652 regulates myoblasts differentiation and survival by targeting ISL1

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Journal of Integrative Agriculture 2023年第5期22卷 1502-1513页

作者： ZHOU Xue-lan GUO Xian LIANG Chun-nian CHU Min WU Xiao-yun YAN Ping Key Laboratory of Yak Breeding Engineering of Gansu Province Lanzhou Institute of Husbandry and Pharmaceutical SciencesChinese Academy of Agricultural SciencesLanzhou 730050P.R.China Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau Ministry of Agriculture and Rural AffairsLanzhou 730050P.R.China

The growth and development of skeletal muscle also determine the meat production of yak, ultimately affecting the economic benefits. Hence, improving growth performance is a top priority in the yak industry. Skeletal muscle development is a complex process involving the regulation of several genes, including microRNAs(miRNAs). However,the transcription of miRNAs in yak skeletal muscle during prenatal to postnatal stages is unknown. We used small RNA sequencing(small RNA-Seq) to determine the global miRNAs of longissimus dorsi muscle from yak(the samples were collected from three fetuses and three adults). Totally 264 differently expressed miRNAs(|log2(fold change)|>1and P-value≤0.05) were detected between the two groups. Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) analysis showed that differently expressed miRNAs-targeted genes participated in pathways associated with muscle development, such as MAPK, PI3K-Akt, and Hippo signaling pathways, etc. MiR-652, which was up-regulated in the fetal group, was transfected into C2C12 myoblasts to examine its role. miR-652 promoted(P≤0.05)proliferation and differentiation, but inhibited(P≤0.001) apoptosis at early period. Furthermore, miR-652 reduced(P≤0.001) the proportion of C2C12 myoblasts in the G1 phase while increasing(P≤0.01) the proportion of cells in the S and G2 phases. Dual-luciferase reporter assays indicated that ISL1 served as a target of miR-652. In general, these findings expand our understanding of yak skeletal muscle miRNAs, and suggested that miR-652 probably regulated myogenesis by regulating ISL1.

关键词： skeletal muscle small RNA sequencing miR-652 C2C12 myoblast /SL1

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