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Metabolites from marine invertebrates and their symbiotic microorganisms: molecular diversity discovery, mining, and application

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Marine Life Science & Technology 2019年第1期1卷 60-94页

作者： Lu Liu Yao-Yao Zheng Chang-Lun Shao Chang-Yun Wang Key Laboratory of Marine Drugs the Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China Single-Cell Center CAS Key Laboratory of Biofuels and Shandong Key Laboratory of Energy GeneticsQingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Institute of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China

Metabolites from marine organisms have proven to be a rich source for the discovery of multiple potent bioactive moleculeswith diverse structures. In recent years, we initiated a program to investigate the diversity of the secondary metabolites frommarine invertebrates and their symbiotic microorganisms collected from the South China Sea. In this review, representativecases are summarized focusing on molecular diversity, mining, and application of natural products from these marineorganisms. To provide a comprehensive introduction to the field of marine natural products, we highlight typical moleculesincluding their structures, chemical synthesis, bioactivities and mechanisms, structure-activity relationships as well as biogenesis. The mining of marine-derived microorganisms to produce novel secondary metabolites is also discussed through theOSMAC strategy and via partial chemical epigenetic modification. A broad prospectus has revealed a plethora of bioactivenatural products with novel structures from marine organisms, especially from soft corals, gorgonians, sponges, and theirsymbiotic fungi and bacteria.

关键词： Marine invertebrates Symbiotic microorganisms Marine natural products molecular diversity Bioactivities Marine drugs

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molecular diversity of the Human Immunodeficiency Virus Type 1 in Metropolitan Cities in Central Africa: An Update of Data

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World Journal of AIDS 2020年第2期10卷 80-93页

作者： Ben Ilunga Bulanda Berry Ikolango Bongenya Adawaye Chatte Elvis Tshunza Kateba Jean-Yves Debels Kabasele Médard Okonda Omakoy Divine Chuga Christian Tshibumbu Idriss Mwanaut Erick Ntambwe Kamangu Research Group “Focus HIV/AIDS” Kinshasa Democratic Republic of Congo University Institute of Sciences and Technologies of Abéché Abéché Chad Service of molecular Biochemistry Department of Basic Sciences Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo

The Human Immunodeficiency Virus (HIV) has a diversity that is equal to the complexity of its management. The group M (Major) is the dominant group in Sub-Saharan Africa and its distribution is very heterogeneous;the diversity of the virus is more heterogeneous in this region than elsewhere in the world which follows a complex and specific algorithm because of geographical positions and countries. This distribution is very dynamic, evolving and unpredictable. This review aimed to expose the specifics of the HIV Type 1 epidemic in Central Africa, in terms of the different molecular variants of HIV published for the region compared to the geographic location. Both Type 1 and Type 2 of HIV are prevalent in sub-Saharan Africa due to distinct geographical contexts. HIV-2 is mainly documented in West and Central Africa, particularly in Cameroon, Guinea-Bissau, Gambia, Senegal, Ivory Coast and Burkina-Faso however HIV-1 infection is widely distributed across the continent. The HIV-1 epidemic in Sub-Saharan Africa is dominated by the Group M. The different subtypes respect a certain geographical distribution across the continent. West Africa is dominated by subtype A, East and South Africa are dominated by subtype C, while Central Africa is dominated by strains A, C, D, F, H, J, CRF01-AE and CRF02-AG. This review is the first to present de molecular diversity of HIV-1 in metropolitan cities in all central African countries. The Circulating Recombinant Form (CRF02_AG) and subtypes A and G are present in all Central African countries and are also the most commonly encountered;followed by the subtypes D, F, G, C, B, J, K and several Circulating Recombinant Forms that are not represented in all Central African countries.

关键词： molecular diversity HIV Sub-Saharan Countries Metropolitan Cities

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molecular diversity of root associated fungi（RAF）colonizing the Xishuangbanna tropical rainforest

Molecular diversity of root associated fungi（RAF）colonizin...

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2010年中国菌物学会学术年会

作者： LI Tao ZHANG XingTao ZHAO ZhiWei~* (Laboratory for Conservation and Utilization of Bioresources and Key Laboratory for Microbial Resources of the Ministry of Education Yunnan University Kunming 650091 China)

＜正＞The diversity of root associated fungi（RAF） conlonizing Colebrookea oppositifolia and Pterospermum menglunense in primary forest,Osbeckia chinensis and Eurysolen gracilis in secondary forest of Xishuangbanna tropical rainforest was analyzed using the ITS rDNA genes. A total of 1945 were screened by restriction fragment length polymorphism（RFLP） with three restriction enzymes（Alu I,Hinf I,Msp I）,and 595 RFLP patterns were selected and sequenced. RAF belonging to 17 orders in 4 subphyla were identified based on phylogenetic analysis of these sequences.Among those RAF,most endophytic fungi belong to the Ascomycetes and Basidiomycete and some endophytic fungi related to Sphaeropsidales,Dothideales,Agaricales, Tremellales,Glomerales have a common distribution and some taxa such as Mucorales, Lycoperdales are specific to habitats and host plants or even possibly rare.The∫-LIBSHUFF analysis revealed that the distinct RAF communities associated with the dominant plants of two habitats.Compared the RAF species richness,diversity and community composition among the two habitats,intensive anthropogenic activities including fire,plantations,agriculture, commercial logging greatly affected not only the communities of the rainforest,but also their root associated fungi.

关键词： Root associated fungi molecular diversity Xishuangbanna tropical rainforest

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Copper Nitrate-Mediated Selective Bond Cleavage of Alkynes:Diverse Synthesis of Isoxazoles

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Chinese Journal of Chemistry 2023年第23期41卷 3299-3304页

作者： Jianan Liu Kaijing Zhou Shaobo Sun Mingchun Gao Bin Xu Department of Chemistry Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong)Shanghai Engineering Research Center of Organ RepairInnovative Drug Research CenterSchool of MedicineShanghai UniversityShanghai200444 China Qianweichang College Shanghai UniversityShanghai200444 China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai200032 China

An unprecedented copper nitrate-mediated bond cleavage of alkynes was developed for the modular synthesis of isoxazoles,where either C—S bond or C≡C triple bond was cleaved selectively.Substituents attached to the C≡C triple bonds could differentiate the chemical bonds cleavage and reaction pathways disparately.Various transformations of products illustrate promising applications of the given protocols.

关键词： Alkynes Bond cleavage Copper nitrate Cyclization Isoxazoles molecular diversity N-Heterocycles Substituent effects

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diversity of Arbuscular Mycorrhizal Fungi Associated with Six Rice Cultivars in Italian Agricultural Ecosystem Managed with Alternate Wetting and Drying

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Rice science 2023年第4期30卷 348-358,I0028-I0030页

作者： Veronica VOLPE Franco MAGURNO Paola BONFANTE Stefano GHIGNONE Erica LUMINI Department of Life Sciences and Systems Biology University of TurinV.le P.A.Mattioli 25I-10125 TurinItaly Institute of Biology Biotechnology and Environmental ProtectionFaculty of Natural SciencesUniversity of Silesia in KatowiceJagiellońska 28Katowice 40-032Poland Institute for Sustainable Plant Protection-Turin Unit National Research Council of ItalyV.le P.A.Mattioli 25I-10125 TurinItaly

Alternate wetting and drying(AWD)system,in which water has been reduced by approximately 35%with an increased occurrence of beneficial arbuscular mycorrhizal(AM)symbiosis and no negative impact on rice yield,was proposed to utilize water and nutrients more sustainable.In this study,we selected six rice cultivars(Centauro,Loto,Selenio,Vialone nano,JSendra and Puntal)grown under AWD conditions,and investigated their responsiveness to AM colonization and how they select diverse AM taxa.In order to investigate root-associated AM fungus communities,molecular cloning-Sanger sequencing on small subunit rDNA data were obtained from five out of the six rice cultivars and compared with Next Generation Sequencing(NGS)data,which were previously obtained in Vialone nano.The results showed that all the cultivars were responsive to AM colonization with the development of AM symbiotic structures,even if with differences in the colonization and arbuscule abundance in the root systems.We identified 16 virtual taxa(VT)in the soil compartment and 7 VT in the root apparatus.We emphasized that the NGS analysis gives additional value to the results thanks to a more in-depth reading of the less represented AM fungus taxa.

关键词： alternate wetting and drying system arbuscular mycorrhizal fungi rice molecular diversity virtual taxa

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Direct Synthesis of Structurally Divergent Indole Alkaloids from Simple Chemicals

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Chinese Journal of Chemistry 2018年第9期36卷 815-818页

作者： Tao Shen Bencong Zhu Fengguirong Lin Jun Pan Jialiang Wei Xiao Luo Jianzhong Liu Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Xue Yuan Rd. 38 Beijing 100191 China State Key Laboratory of Organometallic Chemistry Chinese Academy of Sciences Shanghai 200062 China

A direct and structurally divergent synthesis of indole alkaloids from very simple 2-vinylanilines, alkynes and TBN via a novel substrate flag- mentation/cycloaddition strategy has been developed, which provides an efficient noble-metal-free approach to access a library of highly valuable indole derivatives of tryptamines and tryptamine-related oximes, lactams, and lactones, as well as β-carbolines, spiroindolines, and hexa-hydropyrrolo[2,3-b]- indoles.

关键词： C--C bond cleavage molecular diversity indole alkaloids trypthamines radicals

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The intriguing chemistry and biology of sulfur-containing natural products from marine microorganisms(1987-2020)

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Marine Life Science & Technology 2021年第4期3卷 488-518页

作者： Yang Hai Mei-Yan Wei Chang-Yun Wang Yu-Cheng Gu Chang-Lun Shao Key Laboratory of Marine Drugs School of Medicine and PharmacyThe Ministry of Education of ChinaOcean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China College of Food Science and Engineering Ocean University of ChinaQingdao 266003China Syngenta Jealott’s Hill International Research Centre BracknellBerkshire RG426EYUK

Natural products derived from marine microorganisms have received great attention as a potential resource of new compound entities for drug discovery.The unique marine environment brings us a large group of sulfur-containing natural products with abundant biological functionality including antitumor,antibiotic,anti-inflammatory and antiviral activities.We reviewed all the 484 sulfur-containing natural products(non-sulfated)isolated from marine microorganisms,of which 59.9%are thioethers,29.8%are thiazole/thiazoline-containing compounds and 10.3%are sulfoxides,sulfones,thioesters and many others.A selection of 133 compounds was further discussed on their structure-activity relationships,mechanisms of action,biosynthesis,and druggability.This is the first systematic review on sulfur-containing natural products from marine microorganisms conducted from January 1987,when the first one was reported,to December 2020.

关键词： Sulfur-containing natural products Marine microorganisms molecular diversity Bioactivities Marine drugs

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Genetic diversity in eggplant(Solanum melongena L.)germplasm from three secondary geographical origins of diversity using SSR markers

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BIOCELL 2021年第5期45卷 1393-1401页

作者： DEBI RANI DATTA MOHD RAFII YUSOP AZIZAH MISRAN MASHITAH JUSOH YUSUFF OLADOSU FATAI AROLU AZADUL HAQUE NADZIRAH MSULAIMAN Institute of Tropical Agriculture and Food Security Universiti Putra MalaysiaSerdangSelangor43400Malaysia Department of Crop Science Faculty of AgricultureUniversiti Putra MalaysiaSerdangSelangor43400Malaysia

Indo-Burmese region was the primary center of eggplant diversity from where the crop extended to several secondary origins of diversity.In this study,the genetic diversity among fifty-six eggplant accessions collected from three countries was assessed using sixteen polymorphic SSR markers to determine suitable parents for heterotic hybridization.The estimation of genetic diversity among the population of three countries(Bangladesh,Malaysia,and Thailand)varied from 0.57 to 0.74,with Shannon’s index value of 0.65.The mean value of expected heterozygosity and Nei’s index was 0.49,with an average PIC value of 0.83.A dendrogram was constructed based on UPGMA(unweighted pair group method with arithmetic mean),and the dendrogram categorized all accessions into six groups.The AMOVA(analysis of molecular variance)revealed a 77%total variation within the population from three different countries and 23%total variation among the populations.The result revealed a high genetic differentiation among the eggplant germplasms while the accessions that are farther from each other show a high level of diversity;thus,they can be recommended as parental in breeding programs.Hence,accessions,EB12,ET11,ET13,ET15,ET16,and ET17 could be crossed with accessions EM3,EB34,and EB3 for improvement in the future breeding program.

关键词： Solanum melongena molecular diversity Genomic-SSR EST-SSR

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Cultivation-Independent Analysis of the Development of the Lactobacillus spp.Community in the Intestinal Tract of Newborn Piglets

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Agricultural Sciences in China 2011年第3期10卷 438-447页

作者： YAO Wen ZHU Wei-yun Hauke Smidt Martin W A Verstegen College of Animal Science and Technology Nanjing Agricultural UniversityNanjing210095PR．China Laboratory of Microbiology Wageningen University Wageningen 6703 CT The Netherlands Department of Animal Sciences Wageningen University Wageningen 67004H The Netherlands

molecular diversity and development of the Lactobacillus community in the intestinal tract, as influenced by age and intestinal compartment, were studied in one litter of 12 conventionally raised piglets. Piglets were euthanized at each week （3 animals per time）. Digesta and tissue samples from stomach, duodenum, jejunum, ileum, caecum, colon, and rectum were collected and analysed by using 16S ribosomal RNA-based methods. DGGE （denaturing gradient gel electrophoresis） profiles revealed that the Lactobacillus communities throughout the GI tract from duodenum to rectum showed good stability at same age. This indicates that fecal Lactobacillus communities can effectively represent the intestinal community. Two dominant bands were found in tissue samples of the small intestine, suggesting that the lactobacilli can adhere to the small intestinal wall. The Lactobacillus communities in different GI tract compartments developed over time. A successional change of Lactobacillus communities was observed from birth, through creep feeding to one week after weaning, showing a trend from simple to complex and back to simple. Furthermore, a clone library of Lactobacillus spp. 16S rRNA gene sequences were generated from jejunal and colonic chymes. Six dominant DGGE bands generated from jejunal chymes were matched with sequences that show 94-98% similarity to the bands derived from L. reuteri, L. delbrueckii, and L. crispatus. Seven dominant DGGE bands generated from colon chymes were matched with sequences that show 88-99% similarity to those derived from L. reuteri, L. delbrueckii, L. amylovorus/L. sobrius, and L. acidophilus. Amplicons related to L. reuteri were found in all DGGE fingerprints from jejunal digesta of age of weeks 1, 3, and 4. Amplicons related to L. amylovorus/L. sobrius were present in all DGGE fingerprints from colonic digesta of age of week 1, 3, and 4. Amplicons related to L. delbrueckii were found before weaning, L. crispatus after creep feeding before weaning and L. acidophilus after weaning. This indica

关键词： molecular diversity 16S rRNA gene denaturing gradient gel electrophoresis （DGGE） Lactobacillus community piglets

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Spatial isolation and genetic differentiation in naturally fragmented plant populations of the Swiss Alps

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Journal of Plant Ecology 2008年第3期1卷 149-159页

作者： Patrick Kuss AndreaRPluess Hafdı´s HannaÆgisdottir Jurg Stocklin Institute of Botany University of BaselSchonbeinstrasse 6CH-4056BaselSwitzerland Institute of Plant Sciences University of BernAltenbergrain21CH-3013BernSwitzerland Institute for Terrestrial Ecosystems Ecosystem ManagementETH ZurichUniversitatstrasse 168092 ZurichSwitzerland

The effect of anthropogenic landscape fragmentation on the genetic diversity and adaptive potential of plant populations is a major issue in conservation biology.However,little is known about the partitioning of genetic diversity in alpine species,which occur in naturally fragmented habitats.Here,we investigate molecular patterns of three alpine plants(Epilobium fleischeri,Geum reptans and Campanula thyrsoides)across Switzerland and ask whether spatial isolation has led to high levels of population differentiation,increasing over distance,and a decrease of within-population variability.We further hypothesize that the contrasting potential for long-distance dispersal(LDD)of seed in these species will considerably influence and explain diversity partitioning.Methods For each study species,we sampled 20–23 individuals from each of 20–32 populations across entire Switzerland.We applied Random Amplified Polymorphic Dimorphism markers to assess genetic diversity within(Nei’s expected heterozygosity,He;percentage of polymorphic bands,Pp)and among(analysis of molecular variance,Ust)populations and correlated population size and altitude with within-population diversity.Spatial patterns of genetic relatedness were investigated using Mantel tests and standardized major axis regression as well as unweighted pair group method with arithmetic mean cluster analyses and Monmonier’s algorithm.To avoid known biases,we standardized the numbers of populations,individuals and markers using multiple random reductions.We modelled LDD with a high alpine wind data set using the terminal velocity and height of seed release as key parameters.Additionally,we assessed a number of important life-history traits and factors that potentially influence genetic diversity partitioning(e.***.breeding system,longevity and population size).Important findings For all three species,we found a significant isolation-by-distance relationship but only a moderately high differentiation among populations(Ust:22.7,14.8 and 16.8%,for E.fleischeri,G.reptans and C

关键词： Campanula thyrsoides Epilobium fleischeri Geum reptans isolation by distance molecular diversity

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