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Advances in the diagnosis and treatment of met-variant digestive tract tumors

World Journal of Gastrointestinal Oncology 2024年第11期16卷 4338-4353页

作者： Chen Zhang Hu-Ke Dong Jian-Ming Gao Qi-Qi Zeng Jiang-Tao Qiu Jia-Jia Wang The First Department of Radiation Oncology Lu’an Hospital of Traditional Chinese Medicine of Anhui ProvinceLu’an 237000Anhui ProvinceChina The Fourth Department of Oncology The First Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina The First Department of Oncology The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230000Anhui ProvinceChina Department of Gastroenterology Nanjing University Affiliated Gulou HospitalNanjing 210008Jiangsu ProvinceChin Department of Gastrointestinal Surgery Beijing Tsinghua Changgung HospitalBeijing 100084China Ultrasound of Medicine Department The Second Affiliated Hospital of Anhui Medical UniversityHefei 230601Anhui ProvinceChina

The receptor tyrosine kinase encoded by the met gene plays an important role in various cellular processes such as growth,survival,migration and angiogenesis,and its abnormal activation is closely related to the occurrence and development of various *** article reviews the recent advances in diagnosis and treatment of met-variant digestive tract *** terms of diagnosis,the application of next-generation sequencing technology and liquid biopsy technology makes the detection of met variants more accurate and efficient,providing a reliable basis for individualized *** terms of treatment,met inhibitors such as crizotinib and cabotinib have shown good efficacy in clinical *** addition,the combination of immunotherapy and met inhibitors also demonstrated potential synergies,further improving the therapeutic ***,the complexity and heterogeneity of drug resistance mechanisms are still one of the difficulties in current *** the future,it is necessary to further deepen the understanding of the mechanism of met variation and explore new combination treatment strategies to improve the overall survival rate and quality of life of *** diagnosis and treatment of met-variant digestive tract tumors are moving towards precision and individualization,and have broad application prospects.

关键词： Digestive tract neoplasms Interstitial epithelial transfer factor Targeted therapy met variant Survival prognosis

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