Advances in the diagnosis and treatment of MET-variant digestive tract tumors
作者机构：The First Department of Radiation OncologyLu’an Hospital of Traditional Chinese Medicine of Anhui ProvinceLu’an 237000Anhui ProvinceChina The Fourth Department of OncologyThe First Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina The First Department of OncologyThe First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230000Anhui ProvinceChina Department of GastroenterologyNanjing University Affiliated Gulou HospitalNanjing 210008Jiangsu ProvinceChin Department of Gastrointestinal SurgeryBeijing Tsinghua Changgung HospitalBeijing 100084China Ultrasound of Medicine DepartmentThe Second Affiliated Hospital of Anhui Medical UniversityHefei 230601Anhui ProvinceChina
出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文）)
年 卷 期：2024年第16卷第11期
页 面：4338-4353页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：2023 Anhui Province Clinical Medical Research Transformation Project No.202304295107020016
主 题：Digestive tract neoplasms Interstitial epithelial transfer factor Targeted therapy MET variant Survival prognosis
摘 要：The receptor tyrosine kinase encoded by the MET gene plays an important role in various cellular processes such as growth,survival,migration and angiogenesis,and its abnormal activation is closely related to the occurrence and development of various *** article reviews the recent advances in diagnosis and treatment of MET-variant digestive tract *** terms of diagnosis,the application of next-generation sequencing technology and liquid biopsy technology makes the detection of MET variants more accurate and efficient,providing a reliable basis for individualized *** terms of treatment,MET inhibitors such as crizotinib and cabotinib have shown good efficacy in clinical *** addition,the combination of immunotherapy and MET inhibitors also demonstrated potential synergies,further improving the therapeutic ***,the complexity and heterogeneity of drug resistance mechanisms are still one of the difficulties in current *** the future,it is necessary to further deepen the understanding of the mechanism of MET variation and explore new combination treatment strategies to improve the overall survival rate and quality of life of *** diagnosis and treatment of MET-variant digestive tract tumors are moving towards precision and individualization,and have broad application prospects.
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