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Electroacupuncture exerts neuroprotective effects on ischemia/reperfusion injury in JNK knockout mice：the underlying mechanism

引用

Neural Regeneration Research 2018年第9期13卷 1594-1601页

作者： Chun-Xiao Wu Yi-Hui Feng Lu Yang Zhu-Lian Zhan Xiu-Hong Xu Xiao-Ying Hu Zhi-Hua Zhu Guo-Ping Zhou School of Traditional Chinese Medicine Southern Medical University Guangzhou Guangdong Province China Medical College of Acu-Moxi and Rehabilitation Guangzhou University of Chinese Medicine Guangzhou Guangdong Province China Central Hospital of Qingdao Qingdao Shandong Province China Traditional Chinese Medicine-Integrated Hospital the Affiliated Hospital of Southern Medical University Guangzhou Guangdong ProvinceChina Ruikang Hospital Affiliated to Guangxi College of Traditional Chinese Medicine Nanning Guangxi Zhuang Autonomous Region China

Simple regulation of c-Jun N-terminal kinase（JNK） or p38 mitogen-activated protein kinase（MAPK） pathways is not enough to trigger cell ***,activation of the stress activated pathway（JNK/p38 MAPK） together with inhibition of the growth factor activated extracellular signal-regulated kinase（ERK） pathway can promote cell *** hypothesized that inhibition of the JNK or p38 pro-apoptotic pathway and activating the ERK pathway could be the mechanism of anti-apoptosis following cerebral ischemia/reperfusion *** investigate the mechanism of the protective effect of electroacupuncture on cerebral ischemia/reperfusion injury in JNK knockout mice,mouse models of cerebral ischemia/reperfusion injury were established by Longa’s *** was conducted at acupoints Chize（LU5）,Hegu（LI4）,Sanyinjiao（SP6） and Zusanli（ST36） 1.5 hours after ischemia/reperfusion injury for 20 minutes,once a *** neurological function was evaluated using neurological deficit *** expression of phospho-extracellular signal-regulated kinase（p-ERK） and phospho-p38（p-p38） in JNK knockout mice was detected using double-labeling immunofluorescence and western blot *** m RNA expression of ERK and p38 was measured by quantitative real-time polymerase chain *** improved neurological function,increased the immunoreactivity and relative expression of p-ERK and reduced that of p-p38 in the cerebral cortex and hippocampus on the injured *** increased m RNA expression of ERK,but decreased that of p38 in the cerebral cortex and hippocampus on the injured *** conclusion,electroacupuncture upregulated the protective ERK pathway and inhibited the pro-apoptotic p38 pathway,thereby exerting a neuroprotective effect and improving the neurological function in JNK knockout mice.

关键词： nerve regeneration mapks signaling pathway cerebral ischemia/reperfusion stress-activated pathway growth factor-activatedpathway electroacupuncture apoptosis

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