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mannitol inhibits the proliferation of neural stem cell by a p38 mitogen-activated protein kinase-dependent signaling pathway

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Chinese Journal of Traumatology 2024年第1期27卷 42-52页

作者： Hai-Zhen Duan Xin Zhou Quan Hu Meng-Long Liu Shu-Hong Wang Ji Zhang Xu-Heng Jiang Tian-Xi Zhang An-Yong Yu Department of Emergency Affiliated Hospital of Zunyi Medical UniversityZunyi563000Guizhou provinceChina Dazhou Vocational College of Chinese Medicine Dazhou635000Sichuan provinceChina Dachuan District Traditional Chinese Medicine Hospital Dazhou635000Sichuan provinceChina

Purpose:mannitol is one of the first-line drugs for reducing cerebral edema through increasing the extracellular osmotic ***,long-term administration of mannitol in the treatment of cerebral edema triggers damage to neurons and *** that neural stem cell(NSC)is a subpopulation of main regenerative cells in the central nervous system after injury,the effect of mannitol on NSC is still *** present study aims to elucidate the role of mannitol in NSC ***:C57 mice were derived from the animal house of Zunyi Medical University.A total of 15 pregnant mice were employed for the purpose of isolating NSCs in this ***,mouse primary NSCs were isolated from the embryonic cortex of mice and subsequently identified through immunofluorescence *** order to investigate the impact of mannitol on NSC proliferation,both cell counting kit-8 assays and neurospheres formation assays were *** vitro effects of mannitol were examined at various doses and time *** order to elucidate the role of Aquaporin 4(AQP4)in the suppressive effect of mannitol on NSC proliferation,various assays including reverse transcription polymerase chain reaction,western blotting,and immunocytochemistry were conducted on control and mannitol-treated ***,the phosphorylated p38(p-p38)was examined to explore the potential mechanism underlying the inhibitory effect of mannitol on NSC ***,to further confirm the involvement of the p38 mitogen-activated protein kinase-dependent(MAPK)signaling pathway in the observed inhibition of NSC proliferation by mannitol,SB203580 was *** data were analyzed using SPSS 20.0 software(SPSS,Inc.,Chicago,IL).The statistical analysis among multiple comparisons was performed using one-way analysis of variance(ANOVA),followed by Turkey’’s post hoc test in case of the data following a normal distribution using a Shapiro-Wilk normality *** betwe

关键词： mannitol Cerebral edema Neural stem cell Proliferation AQP4 p38 MAPK signaling pathway

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Densities and Viscosities of the Quaternary System mannitol-Sorbitol- D-Glucose-H2O and Its Ternary Subsystems at 298.15K

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Chinese Journal of Chemical Engineering 2007年第5期15卷 703-709页

作者：刘艳升时铭显曹睿张耀辉胡玉峰 Oil ＆ Gas Science and Engineering Group China University of Petroleum Beijing 102200 China

To check the applicabilities of the simple density equation and viscosity equation in the semi-ideal solution theory to nonelectrolyte solutions, the densities and viscosities were measured for the quaternary system mannitol-sorbitol-D-glucose-HzO and its ternary subsystems mannitol-D-glucose-H2O and sorbitol-D-glucose-H2O at 298.15K. The results were used to test the applicability of the simple equations for the density and viscosity of the multicomponent nonelectrolyte solution. The agreements between the predicted and measured results are good.

关键词： density viscosity mannitol sorbitol D-glucose simple predictive equations

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Characterization of a novel regulatory pathway for mannitol metabolism and its coordination with biofilm formation in Mycobacterium smegmatis

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Journal of Genetics and Genomics 2018年第9期45卷 477-488页

作者： Jialing Hu Hua Zhang Si Zhou Weihui Li Zheng-Guo He National Key Laboratory of Agricultural Microbiology College of Life Science and TechnologyHuazhong Agricultural University

Biofilm formation has been implicated to be tightly regulated in bacteria. Mycobacterial species possess a unique cell-wall structure; however, the underlying regulation mechanism for their biofilm formation remains largely unclear. In this study, we characterized a hypothetical mannitol metabolism and transportation gene cluster（Ms5571-Ms5576）, designated as mmt operon, whose expression significantly contributes to the biofilm formation in Mycobacterium smegmatis. We showed that in the operon the Ms5575 gene encodes a GntR-like transcriptional repressor and the Ms5576 gene encodes a mannitol2-dehydrogenase which can produce D-mannitol from D-mannose. Strikingly, the D-mannitol molecule can derepress the negative regulation of Ms5575 on the mmt operon to stimulate the operon＇s expression. Consistently, addition of D-mannitol into the medium can obviously induce mycobacterial biofilm formation. Furthermore, we found that Ms0179 positively regulates the mmt operon through its downstream regulator Ms0180. Ms0180 directly binds the mmt operon to positively regulate its expression. Both Ms0179 and Ms0180 significantly affect the mycobacterial biofilm formation. Taken together, we explored a regulatory pathway for the mannitol metabolism and its coordination with the biofilm formation in M. smegmatis. This finding provides novel insights into the unique mechanism of biofilm formation regulation in mycobacteria.

关键词： Transcription regulation Biofilm formation mannitol Mycobacteria

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Evaluation of mannitol effect in patients with acute hepatic failure and acute-on-chronic liver failure using conventional MRI,diffusion tensor imaging and in-vivo proton MR spectroscopy

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World Journal of Gastroenterology 2008年第26期14卷 4168-4178页

作者： Vivek A Saraswat Sona Saksena Kavindra Nath Pranav Mandal Jitesh Singh M Albert Thomas Ramkishore S Rathore Rakesh K Gupta Department of Gastroen-terology Sanjay Gandhi Post Graduate Institute of Medical SciencesLucknowUttar Pradesh 226014India Department of Radiodiagnosis Sanjay Gandhi Post Graduate Institute of Medical SciencesLucknowUttar Pradesh 226014 India Department of Gastroen-terology Sanjay Gandhi Post Graduate Institute of Medical SciencesLucknowUttar Pradesh 226014 India Department of Mathematics and Statistics Indian Institute of TechnologyKanpurUttar Pradesh 226014India Department of Radiological Sciences David Geffen School of Medicine at UCLA10833 Le Conte AvenueLos AngelesCalifornia 90095-1721United States Department of Mathematics and Statistics Indian Institute of TechnologyKanpurUttar Pradesh 226014India Department of Radiodiagnosis Sanjay Gandhi Post Graduate Institute of Medical SciencesLucknowUttar Pradesh 226014 India

AIM： To evaluate the effect of an intravenous bolus of mannitol in altering brain metabolites, brain water content, brain parenchyma volume, cerebrospinal fluid （CSF） volume and clinical signs in controls and in patients with acute liver failure （ALF） and acute- on-chronic liver failure （ACLF）, by comparing changes in conventional magnetic resonance imaging （MRI）, in vivo proton magnetic resonance spectroscopy （PMRS） and diffusion tensor imaging （DTI） before and after its ***： Five patients each with ALF and ACLF in grade 3 or 4 hepatic encephalopathy and with clinical signs of raised intracranial pressure were studied along with five healthy volunteers. After baseline MRI, an intravenous bolus of 20% mannitol solution was given over 10 min in controls as well as in patients with ALF and ACLE Repeat MRI for the same position was acquired 30 rnin after completing the rnannitol injection. RESULTS： No statistically significant difference was observed between controls and patients with ALF and ACLF in metabolite ratios, DTI metrics and brain volume or CSF volume following 45 rain of mannitol infusion. There was no change in clinical status at the end of post-mannitol imaging. CONCLUSION： The osmotic effect of mannitol did not result in significant reduction of brain water content, alteration in metabolite ratios or any change in the clinical status of these patients during or within 45 min of mannitol infusion.

关键词： mannitol Acute liver failure Acute-on-chronic liver failure Proton MR spectroscopy Diffusion tensor imaging

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Blood-letting punctures at twelve Jing-Well points of the hand can treat cerebral ischemia in a similar manner to mannitol

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Neural Regeneration Research 2013年第6期8卷 532-539页

作者： Xuan Lu Zelin Chen Yi Guo Liang Gao Liyuan Jiang Zhongzheng Li Jianqiao Fang Experimental Acupuncture Research Center Tianjin University of Traditional Chinese Medicine Third Clinical Medical College of Zhejiang Chinese Medical University

A rat model of middle cerebral artery permanent occlusion was established using the modified Longa method. Successfully established model animals were treated by blood-letting puncture at twelve Jing-Well points of the hand, and/or by injecting mannitol into the caudal vein twice daily. Brain tissue was collected at 24, 48 and 72 hours after modeling, and blood was collected through the retinal vein before Evans blue was injected, approximately 1 hour prior to harvesting of brain tissue. Results showed that Evans blue leakage into brain tissue and serum nitric oxide synthase activity were significantly increased in model rats. Treatment with blood-letting punctures at twelve Jing-Well points of the hand and/or injection of mannitol into the caudal vein reduced the amount of Evans blue leakage into the brain tissue and serum nitric oxide synthase activity to varying degrees. There was no significant difference between single treatment and combined treatment. Experimental findings indicate that blood-letting punctures at twelve Jing-Well points of the hand can decrease blood-brain barrier permeability and serum nitric oxide synthase activity in rats following middle cerebral artery occlusion, and its effect is similar to that of mannitol injection alone and Jing-Well points plus mannitol injection.

关键词： neural regeneration brain injury Jing-Well points of hand acupoint blood-letting mannitol middlecerebral artery occlusion cerebral ischemia cerebral infarction blood-brain barrier nitric oxidesynthase cerebral edema neuroprotection grants-supported paper neuroregeneration

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Is mannitol combined with furosemide a new treatment for refractory lymphedema?A case report

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World Journal of Clinical Cases 2021年第29期9卷 8804-8811页

作者： Hyeon Seong Kim Jae Young Lee Ji Won Jung Kyu Hoon Lee Mi Jung Kim Si-Bog Park Department of Rehabilitation Medicine Hanyang University HospitalSeoul 04763South Korea

BACKGROUND mannitol is a hyperosmolar agent and the combination of mannitol and furosemide is a widely used treatment for intracranial pressure *** the hypertonic properties of mannitol to move water out of intracellular spaces,we hypothesized that mannitol combined with furosemide could relieve focal tissue swelling in refractory *** SUMMARY A 90-year-old female had been diagnosed with intracranial hemorrhage and received a combination of mannitol and furosemide for intracranial pressure *** of the intracranial hemorrhage,she had refractory lymphedema of the left lower extremity since ***,after receiving the mannitol and furosemide,the patient’s lower extremity lymphedema improved *** the mannitol and furosemide were discontinued,the lymphedema worsened in spite of complete decongestive therapy(CDT)and intermittent pneumatic compression treatment(IPC).To identify the presumed effect of mannitol and furosemide on the lymphedema,these agents were resumed,and the lymphedema improved *** The present case raises the possibility that a combination of mannitol and furosemide might be considered another effective therapeutic option for refractory lymphedema when CDT and IPC are ineffective.

关键词： Lymphedema mannitol Furosemide Rehabilitation Intermittent pneumatic compression Case report

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Paradoxical herniation after decompressive craniectomy provoked by mannitol:A case report

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World Journal of Clinical Cases 2022年第15期10卷 4917-4922页

作者： Chuan Du Hua-Juan Tang Shuang-Ming Fan Neurosurgery the Affiliated Hospital of Chengdu UniversityChengdu 610000Sichuan ProvinceChina Neurology West China HospitalSichuan UniversityChengdu 610000Sichuan ProvinceChina

BACKGROUND Paradoxical transtentorial herniation is a rare but life-threatening complication of cerebrospinal fluid drainage in patients with large decompressive ***,paradoxical transtentorial herniation after rapid intravenous infusion of mannitol has not been reported *** SUMMARY A 48-year-old male suffered from a right temporal vascular malformation with *** a coma,the patient was given emergency vascular malformation resection,hematoma removal,and the right decompressive *** patient woke up on the 1st d after the operation and was given 50 g of 20% mannitol intravenously every 8 h without cerebrospinal fluid *** the morning of the 7th postoperative day,after 50 g of 20% mannitol infusion in the Fowler’s position,the neurological function of the patient continued to deteriorate,and the right pupils dilated to 4 mm and the left to 2 ***,computed tomography revealed an increasing midline shift and transtentorial *** patient was placed in a supine position and given 0.9% saline intravenously.A few hours later,the patient was fully awake with purposeful movements on his right side and normal *** Paradoxical herniation may occur,although rarely,after infusing high-dose mannitol intravenously in the Fowler’s position in the case of a large craniectomy *** attempt should be made to place the patient in the supine position because this simple maneuver may be *** not use high-dose mannitol when the flap is severely sunken.

关键词： Decompressive craniectomy Intracranial hypotension Paradoxical herniation Transtentorial herniation mannitol Case report

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Comparison of half-molar sodium lactate and mannitol to treat brain edema in severe traumatic brain injury:A systematic review

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Chinese Journal of Traumatology 2021年第6期24卷 344-349页

作者： Abdul Hafid Bajamal Tedy Apriawan I.G.M.Aswin R.Ranuh Franco Servadei Muhammad Faris Asra Al Fauzi Department of Neurosurgery Faculty of MedicineUniversitas AirlanggaDr.Soetomo General Academic HospitalSurabayaIndonesia Department of Neurosurgery Humanitas Clinical and Research HospitalHumanitas UniversityMilanItaly

Purpose:Hypertonic fluids such as mannitol and half-molar sodium lactate are given to treat intracranial hypertension in patients with severe traumatic brain injury(TBI).In this study,sodium lactate was compared to mannitol in patients with TBI to investigate the efficacy in reducing intracranial pressure(ICP).Methods:This study was a systematic review with literature research on articles published in any year in the databases of PubMed,ScienceDirect,Asian Journal of Neurosurgery,and Cochrane Central Register of Controlled *** keywords were"half-molar sodium lactate","mannitol","cerebral edema or brain swelling",and"severe traumatic brain injury".The inclusion criteria were(1)studies published in English,(2)randomized control trials or retrospective/prospective studies on TBI patients,and(3)therapies including half-molar sodium lactate and mannitol and(4)sufficient data such as mean difference(MD)and risk ratio(RR).Data analysis was conducted using Review Manager ***:From 1499 studies,a total of 8 studies were *** group reduced ICP of 0.65 times(MD 0.65;p=0.64)and improved cerebral perfusion pressure of 0.61 times(MD 0.61;p=0.88),better than the half-molar group of sodium *** the half-molar group of sodium lactate maintained the mean arterial pressure level of 0.86 times,better than the mannitol group(MD 0.86;p=0.09).Conclusion:Half-molar sodium lactate is as effective as mannitol in reducing ICP in the early phase of brain injury,superior over mannitol in an extended *** is able to prevent intracranial hypertension and give better brain tissue perfusion as well as more stable *** osmolarity is a concern as it increases serum sodium.

关键词： Half-molar sodium lactate mannitol Traumatic brain injuries

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The Effects of Genotype and mannitol Pretreatment on High Frequency Androgenesis in Barley

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Chinese Science Bulletin 1993年第2期38卷 151-155页

作者：李文泽景健康姚根怀胡含 Laiyang Agricultural College Shandong 265200 PRC Institute of Genetics. Academia Sinica Beijing 100101 PRC

Since the success in induction of barley pollen plants through anther culture was achieved by Clapham in 1973, a great amount of efforts have been further made on the study. In the past 20 years, the green plant production has been increased by 100-fold by improving culture methods and media etc. However, there still exist a lot of theoretical and applied problems, for example, the green plantlet yield per anther for most materials except

关键词： anther culture of barley genotype mannitol pretreatment.

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Intravenous mannitol reduces intracompartmental pressure following tibia fractures: A randomized controlled trial

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Chinese Journal of Traumatology 2021年第2期24卷 109-112页

作者： Jerry Nesaraj Viju Daniel Varghese P.R.Boopalan Manasseh Nithyananth Thambu David Sudarsanam Thilak Samuel Jepegnanam Christian Medical College Vellore 632004Tamil NaduIndia Royal Darwin Hospital Darwin 0810Northern TerritoryAustralia

Purpose:Impending compartment syndrome is a common event following closed tibia fractures,which can progress to sinister compartment *** is the only definitive treatment available,though it has its own drawbacks and *** management at present consists of limb elevation and adequate *** study aims at determining whether intravenous administration of mannitol reduced the intracompartmental pressure in patients with closed tibial ***:This is a double blinded,randomized control trial done in a single tertiary care center in ***-five patients were recruited between February 2012 and October *** patients who presented to the emergency department with isolated,closed,high velocity,and proximal 2/3 tibia fractures were included in this *** with contraindication to mannitol were *** were allocated into 2 groups by the investigator using computer generated *** pressure in the anterior compartment of the leg was measured with a handheld Stryker pressure *** either 20%mannitol or 0.9%normal saline as given intravenously in a blinded manner,based on the *** intracompartmental pressure was measured at 0,1 and 3 h after the *** participant,investigator and statistician were masked to the group ***:There was no difference in intracompartmental pressures at 1 or 3 h,between the ***,in patients with the baseline of compartmental pressures30 mmHg,mannitol showed a marked reduction in pressure of 8.5 mmHg at 1 h compared to almost no change in pressure in the saline *** were no adverse events with the use of ***:This preliminary study appears to show that mannitol is useful in the management of the increased compartment *** limitations of this study were that it only involved a small group of patients and the baseline pressures in both the groups were not *** studies are requi

关键词： mannitol Compartment pressures Acute tibial fractures

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