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Modeling lyme disease transmission

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Infectious disease Modelling 2017年第2期2卷 229-243页

作者： Yijun Lou Jianhong Wu Department of Applied Mathematics The Hong Kong Polytechnic UniversityKowloonHong Kong Department of Mathematics and Statistics York UniversityTorontoOntarioM3J 1P3Canada

lyme disease,a typical tick-borne disease,imposes increasing global public health challenges.A growing body of theoretical models have been proposed to better understand various factors determining the disease risk,which not only enrich our understanding on the ecological cycle of disease transmission but also promote new theoretical developments on model formulation,analysis and *** this paper,we provide a review about the models and results we have obtained recently on modeling and analyzing lyme disease transmission,with the purpose to highlight various aspects in the ecological cycle of disease transmission to be incorporated,including the growth of ticks with different stages in the life cycle,the seasonality,host diversity,spatial disease pattern due to host short distance movement and bird migration,co-infection with other tick-borne pathogens,and climate change impact.

关键词： Mathematical model lyme disease Tick-borne disease Basic reproduction number Seasonality Spatial model Biodiversity Co-infection Bird migration

The conflict on posttreatment lyme disease syndrome: a clinical mini review

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Neuroimmunology and Neuroinflammation 2016年第1期3卷 10-13页

作者： Manos Bogdos Sotirios Giannopoulos Maria Kosmidou Department of Neurology School of MedicineUniversity of Ioannina45110 IoanninaGreece Neurosurgical Research Institute School of MedicineUniversity of Ioannina45110 IoanninaGreece st Division of Internal Medicine School of MedicineUniversity of Ioannina45110 IoanninaGreece

Is Borrelia burgdorferi responsible for the persistence of symptoms after the standard successful course of antibiotics in lyme disease patients?This highly controversial issue,concerning the underlying mechanism of posttreatment lyme disease syndrome(PTLDS),still seems to be a matter of intense conflict of *** is the manifestation of nonspecific symptoms including fatigue,musculoskeletal pain,dysesthesias,and neurocognitive deterioration after the standard antimicrobial therapy administered to patients suffering from lyme *** this article,we review the conflicting views and published highlights of recent human studies regarding PTLDS.

关键词： Antibiotic therapy duration of therapy lyme disease nonspecific symptoms posttreatment lyme disease syndrome

lyme disease Presenting as Ankylosing Spondylitis: A Case Report

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Case Reports in Clinical Medicine 2020年第11期9卷 354-359页

作者： Megan Strauchman Mark Morningstar Natural Wellness & Pain Relief Center Grand Blanc MI USA

lyme disease is a rapidly growing tick-borne infection in many parts of the United States. Due to the complexity of the various symptom presentations associated with lyme disease, Borrelia burgdorferi, the bacteria that causes lyme disease, is thought of as a disease-mimicking infection. The present case report summarizes the case of an adult female patient who was initially diagnosed with ankylosing spondylitis. After becoming refractory to autoimmune-based treatment interventions, she presented to an integrative medicine clinic where she was diagnosed with lyme disease. Symptoms resolved after following and completing an anti-microbial based protocol, symptoms resolved. Her symptoms remained resolved at follow-up.

关键词： Ankylosing Spondylitis Infection lyme disease

A Study of the Technique of Western Blot for Diagnosis of lyme disease caused by Borrelia afzelii in China

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Biomedical and Environmental Sciences 2013年第3期26卷 190-200页

作者： LIU Zhi Yun HAO Qin HOU Xue Xia JIANG Yi GENG Zhen WU Yi Mou WAN Kang Lin State Key Laboratory for Infectious disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and Prevention Institute of Pathogenic Biology University of South China YuShui District Center for disease Control and Prevention

Objective To study the technique of Western blot for the diagnosis of lyme disease caused by Borrelia afzelii in China and to establish the standard criteria by operational procedure. Methods FP1, which is the representative strain of B. afzelii in China, was analyzed by SDS-PAGE, electro transfer and irnmunoblotting assays. The molecular weights of the protein bands of FP1 were analyzed by Gel-Pro analysis software. In a study using 451 serum samples （159 patients with lyme disease and 292 controls）, all observed bands were recorded. The accuracy of the WB as a diagnostic test was established by using the ROC curve and Youden index. Results Criteria for a positive diagnosis of lyme disease were established as at least one band of P83/100, P58, P39, OspB, OspA, P30, P28, OspC, P17, and P14 in the IgG test and at least one band of P83/100, P58, P39, OspA, P30, P28, OspC, P17, and P41 in the IgM test. For IgG criteria, the sensitivity, specificity and Youden index were 69.8%, 98.3%, and 0.681, respectively; for IgM criteria, the sensitivity, specificity and Youden index were 47%, 94.2%, and 0.412, respectively.

关键词： lyme disease Western blot Diagnostic method Borrelia afzelii

Posttreatment lyme disease syndrome and myalgic encephalomyelitis/chronic fatigue syndrome:A systematic review and comparison of pathogenesis

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慢性疾病与转化医学:英文版 2023年第3期9卷 183-190页

作者： Natalie A.Bai Christie S.Richardson Department of Psychiatry Rowan‐Virtua School of Osteopathic MedicineMount LaurelNew JerseyUSA

lyme disease is the most common vector-borne illness in the United States and has been causing significant morbidity since its discovery in *** is well-documented that about 10%of patients properly treated with antibiotics never fully recover,but instead go on to develop a chronic illness dubbed,posttreatment lyme disease syndrome(PTLDS)characterized by severe fatigue,cognitive slowing,chronic pain,and sleep *** review includes 18 studies that detail the symptoms of patients with PTLDS and uses qualitative analysis to compare them to myalgic encephalitis/chronic fatigue syndrome(ME/CFS),a strikingly similar *** the majority of the PTLDS studies,at least four of the six major symptoms of ME/CFS were also noted,including substantial impairment in activity level and fatigue for more than 6 months,post-exertional malaise,and unrefreshing *** one of the included PTLDS articles,26 of the 29 ME/CFS symptoms were *** study adds to the expanding literature on the post-active phase of infection syndromes,which suggests that chronic illnesses such as PTLDS and ME/CFS have similar pathogenesis despite different infectious origins.

关键词： chronic fatigue syndrome lyme disease myalgic encephalitis posttreatment lyme disease syndrome systematic review

PathoDNA, an Advanced Diagnostic for lyme disease &Co-Infections Utilizing Next Generation DNA Sequencing with Greater Sensitivity and Selectivity than ELISA/Western Blot

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Advances in Infectious diseases 2021年第4期11卷 405-429页

作者： Robert Schettig Ruth Tan-Lim Daniel Warren Zachary Poteet Rory Sears Michael Hummel Connor Coffin Kendra Quart Christopher Aussems Ronald Matthias Jr. David Medina Matthew Klein Gayle Roberts John C. Oertle III Dino Prato Envita Scottsdale USA

The controversial subject of chronic lyme disease has occupied medical discourse for years while contributing to unprecedented patient suffering in the United States and abroad. A general misunderstanding of lyme disease and overconfidence in the Center for disease Control’s (CDC) recommended two-step test for lyme disease has led to misdiagnosis and incorrect treatment over the years. This leads to increasing medical expenses and worse outcomes for patients. The two-step test, an ELISA immunoblot followed by a confirmatory Western blot, yields accuracy rates as low as 29% for acute lyme disease and 75% for chronic lyme disease. While these practices have been a staple of microbiology for decades, these accuracy rates are unacceptable for diagnostic tests when better technology is available. PathoDNA, a Next-Generation DNA sequencing test for lyme disease and other tick-borne pathogens, achieves accuracy rates of 98% for B. burgdorferi and 95% or greater for other common tick-borne pathogens with superior sensitivity and selectivity. PathoDNA is a Clinical Laboratory Improvement and Amendments (CLIA)-validated laboratory test that achieves these results utilizing Next Generational DNA Sequencing and a proprietary bioinformatics database. Thus, it allows for rapid results and specific identification of tick-borne illnesses. In this article, we will compare this promising technology against the existing standards for diagnosing and testing lyme disease. We believe that PathoDNA can set a new standard for identifying Borrelia and diagnosing lyme disease along with other tick-borne infections.

关键词： lyme disease Ticks Tick-Borne Borrelia Sequencing Diagnosis

Cochlear and Vestibular Functional Study in Patients with Sudden Deafness and lyme disease

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International Journal of Otolaryngology and Head & Neck Surgery 2014年第1期3卷 46-50页

作者： Ziane Selmani Ilmari Pyykko Health Centre of Aava KeravaFinland Department of Otolaryngology University Hospital of TampereUniversity of TampereTampereFinland

lyme disease (LD) and idiopathic sudden deafness (ISD) are supposed to be different diseases with different aetiologies. In an attempt to confirm this assumption, 10 patients with confirmed LD and 12 patients with ISD were consecutively included into the study. Further to the laboratory and audio logical investigation, a low frequency sound (LFS) stimulation on posturography was performed and evaluated. Patients with ISD had higher pure tone average (PTA) than patients with LD (PTA ISD/LD was 72 decibel (dB)/23 dB). There was no difference of vertigo between LD and ISD patients. Patients with ISD have more body sway velocity during the first stimulation than patients with LD. We conclude that the cochlear organ is more affected in ISD patients than in patients with LD. However, the vestibular organ seems to be affected in both diseases. ISD and LD are two different disease entities with different aetiologies but with common otological clinical signs.

关键词： Idiopathic Sudden Deafness lyme disease Low Frequency Sound Stimulation

Respiratory modulation of cardiac vagal tone in lyme disease

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World Journal of Cardiology 2014年第6期6卷 502-506页

作者： Basant K Puri Mussadiq Shah Jean A Monro Michele C Kingston Peter OO Julu Department of Medicine Imperial College LondonHammersmith HospitalLondon W12 0HSUnited Kingdom Imaging Directorate Imperial College LondonHammersmith HospitalLondon W12 0HSUnited Kingdom Department of Neuroscience Breakspear Medical GroupHertfordshire HouseHemel HempsteadHertfordshire HP2 4FDUnited Kingdom Department of Medicine Imperial College LondonLondon SW7 2AZUnited Kingdom National Rett Center SE-832 23 FrsnSweden

AIM: To conduct the first systematic test of the hypothesis that modulation of cardiac vagal tone is impaired in lyme ***: The response of cardiac vagal tone to respiratory modulation was measured in 18 serologically positive lyme disease patients and in 18 ***: The two groups were matched in respect of age,sex,body mass,mean arterial blood pressure,mean resting heart rate and mean resting cardiac vagal tone. The mean maximum cardiac vagal tone during deep breathing in the lyme disease patients [11.2(standard error 1.3)] was lower than in the matched controls [16.5(standard error 1.7); P = 0.02].CONCLUSION: Respiratory modulation of cardiac vagal tone is impaired in lyme disease,which suggests that lyme disease may directly affect the vagus nerve or the brainstem.

关键词： Cardiac vagal tone lyme disease

Optic Neuritis in Acute Neuroborreliosis (lyme disease) in the U.S.-Mexican Border: Case Report

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World Journal of Neuroscience 2016年第2期6卷 126-130页

作者： Ihtesham A. Qureshi Michael F. Maldonado Gustavo J. Rodriguez Salvador Cruz-Flores Alberto Maud Neurology Department Texas Tech University Health Sciences Center El Paso USA Ophthalmology Department Texas Tech University Health Sciences Center El Paso USA

Objective: We describe a patient diagnosed with acute neuroborreliosis presenting with anterior optic neuritis (papillitis) in a non-endemic region. Case Presentation: A 43-year-old previously healthy right handed man admitted due to an insidious onset of severe headache and spells of ascending paresthesias from his right foot into his right arm and face followed by speech arrest and clumsiness of his right hand. His neurologic exam was significant for somnolence, nuchal rigidity and Kernig and Brudzinski signs were present. MRI of the brain with gadolinium showed diffuse hyperintense signal involving the supra and infratentorial cortical sulci, with associated faint diffuse leptomeningeal enhancement, consistent most likely with diffuse leptomeningoencephalitis. EEG: normal. CSF VDRL was negative. Dilated fundus exam revealed mild optic nerve edema more significant to the left than to the right eye, confirmed and measured by spectral domain OCT (Optical Coherence Tomography). There was an evidence of posterior uveitis with an early vitreous hemorrhage superficial to the left optic nerve. lyme disease serum antibody (IgM) Immunoblotting was positive in 2 bands confirming the diagnosis of neuroborreliosis. Conclusion: Optic nerve involvement in lyme disease is an uncommon complication that should be confirmed by specific diagnostic criteria to establish its causal relation.

关键词： Optic Neuritis lyme disease Non-Endemic Papillitis