Respiratory modulation of cardiac vagal tone in Lyme disease

作     者：Basant K Puri Mussadiq Shah Jean A Monro Michele C Kingston Peter OO Julu 

作者机构：Department of MedicineImperial College LondonHammersmith HospitalLondon W12 0HSUnited Kingdom Imaging DirectorateImperial College LondonHammersmith HospitalLondon W12 0HSUnited Kingdom Department of NeuroscienceBreakspear Medical GroupHertfordshire HouseHemel HempsteadHertfordshire HP2 4FDUnited Kingdom Department of MedicineImperial College LondonLondon SW7 2AZUnited Kingdom National Rett CenterSE-832 23 FrsnSweden 

出 版 物：《World Journal of Cardiology》 (世界心脏病学杂志（英文版）（电子版）)

年 卷 期：2014年第6卷第6期

页      面：502-506页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：Cardiac vagal tone Lyme disease 

摘      要：AIM: To conduct the first systematic test of the hypothesis that modulation of cardiac vagal tone is impaired in Lyme ***: The response of cardiac vagal tone to respiratory modulation was measured in 18 serologically positive Lyme disease patients and in 18 ***: The two groups were matched in respect of age,sex,body mass,mean arterial blood pressure,mean resting heart rate and mean resting cardiac vagal tone. The mean maximum cardiac vagal tone during deep breathing in the Lyme disease patients [11.2(standard error 1.3)] was lower than in the matched controls [16.5(standard error 1.7); P = 0.02].CONCLUSION: Respiratory modulation of cardiac vagal tone is impaired in Lyme disease,which suggests that Lyme disease may directly affect the vagus nerve or the brainstem.