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Gene Expression Profile of Pulmonary Tissues in Different Phases of lung ischemia-reperfusion injury in Rats

Journal of Huazhong University of Science and Technology(Medical Sciences) 2007年第5期27卷 564-570页

作者：李劲松聂君陈刚龚勇泉江科杨光海刘磊王建军 Department of Thoracic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology

In order to provide us new clues to induce some endogenous protective molecular mechanisms, the changes in gene expression profile induced by ischemia-reperfusion in pulmonary tissues of rats were investigated and the dynamic mechanism of pulmonary ischemia-reperfusion injury was elucidated. Thirty male Wistar rats were randomly divided into 6 groups： 5 ischemia-reperfusion （I/R） groups （I/R 0-h, I/R 1-h, I/R 3-h, I/R 6-h, I/R 24-h） and control group （n=5 in each）. An in situ ischemia-reperfusion lung injury rat model was established by occluded hilus of lung. The RatRef-12 Expression Beadchip （22 226 gene probes per array） was used to analyze the pattern of gene expression in all groups. The results showed that 648, 340, 711, 1279 and 641 genes were differentially expressed in I/R 0-, 1-, 3-, 6- and 24-h groups respectively. The differentially expressed genes were classified as following 7 functional categories： cytokine, adhesion molecule, growth factor and apoptosis-related factor, oxidation and antioxidation molecule, metabolic enzyme, ion channel and aquaporin, signal transduction molecule. It was suggested that gene chip technology was an effective and quick method for screening differentially expressed genes. Many differentially expressed genes with different functions interacted each other to result in pulmonary ischemia-reperfusion injury.

关键词： lung ischemia-reperfusion injury gene expression gene chip

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Autophagy induced by DAMPs facilitates the inflammation response in lungs undergoing ischemia-reperfusion injury through promoting TRAF6 ubiquitination

Autophagy induced by DAMPs facilitates the inflammation resp...

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第十一届全国免疫学学术大会

作者： Wang Bo Cao Hao Yang Junqi Yang Linshan Guo Xing Wu Manya Zhang Likui Zhan Zhenzhen Research Center for Translational Medicine & Institute of Heart Failure Shanghai East Hospital Tongji University School of Medicine

lung ischemia-reperfusion(I/R)injury remains one of the most common complications after various cardiopulmonary *** inflammation response triggered by the released damage-associated molecular patterns(DAMPs)aggravates... 详细信息

关键词： Alveolar macrophages Autophagy DAMPs lung ischemia-reperfusion injury sterile inflammation

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