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Efficacy and safety of utidelone for the treatment of patients with locally advanced or metastatic non-small-cell lung cancer who have failed standard second-line treatment:A phase 2 clinical trial(BG01-1801)

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cancer Pathogenesis and Therapy 2024年第2期2卷 103-111页

作者： Yuankai Shi Gongyan Chen Yanqiu Zhao Jing Zhao Lin Lin Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study On Anticancer Molecular Targeted DrugsBeijing 100021China Department of Respiration Harbin Medical University Cancer HospitalHarbinHeilongjiang 150040China Respiratory Department of Internal Medicine Henan Provincial Cancer HospitalZhengzhouHenan 450003China Department of Pulmonary and Critcal Care Medicine Peking Union Medical College HospitaChinese Academy of Medical Sciences&Peking Union Medical College Beijing100021China

Background:Chemotherapy remains the standard-of-care for many patients with locally advanced or metastatic non-small-cell lung cancer(NSCLC),but acquired resistance presents *** aim of this open-label,multicenter phase 2 clinical trial was to determine the efficacy and safety of utidelone,a novel genetically engineered epothilone analog and microtubule-stabilizing agent,as a third-or later-line treatment for locally advanced ormetastatic ***:Patients who had failed standard second-line treatment(including platinum-containing chemotherapy or targeted therapy)received utidelone(40 mg/m?via intravenous injection daily,day 1-5)every 21 *** primary endpoint was the objective response rate(ORR).Secondary endpoints were the duration of response(DoR),progression-free survival(PFS),overall survival(OS),and ***:From March 12,2019 to January 18,2021,26 pretreated patients with locally advanced or metastatic NSCLC(100%of patients had received prior platinum and 65.4%patients had received prior taxane treatment)were enrolled(80.8%of patients had adenocarcinoma).At baseline,nine(34.6%)patients had received secondline treatment,10(38.5%)patients had received third-line treatment,and seven(26.9%)patients had received fourth-or later-line *** the data cut-off date of August 10,2021,the median follow-up was 7.49 months(range,1.4-26.7 months).The ORR was 15.4%(95%confidence interval[CI],4.4%-34.9%)in the intention-totreat(ITT)cohort(N=26)and 19.0%(95%CI,5.4%-41.9%)in the per-protocol(PP)cohort(N=21).The disease control rate was 69.2%(95%CI,48.2%-85.7%)and 81.0%(95%CI,58.1%-94.6%)in the ITT and PP cohorts,*** median DoR was 4.1 months(95%CI,3.1-5.1 months)in the ITT *** median PFS was 4.37 months(95%CI,2.50-5.29 months)in the ITT cohort and 4.37 months(95%CI,2.50-9.76 months)in the PP *** median OS was not reached,and the 12-month OS rate was 69%(95%CI,45.1%-84.1%).Grade 3/4 treatment-emergent adverse events occur

关键词： Utidelone Locally advanced or metastatic non-small-cell lung cancer Efficacy Platinum-and taxane-refractory

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Light at night and lung cancer risk:A worldwide interdisciplinary and time-series study

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第1期2卷 56-62页

作者： Runchen Wang Qixia Wang Jianfu Li Jianrong Zhang Shixuan Lyu Wenhao Chi Zhiming Ye Xuanzhuang Lu Ying Shi Yubin Wang Xinjian Wu Ruiyu Hu Mónica Pérez-Ríos Jianxing He Wenhua Liang Department of Thoracic Surgery and Oncology The First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthGuangzhouGuangdong 510120China Department of Respiratory Disease China State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory DiseaseThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510120China Centre for cancer Research&Department of General Practice Faculty of MedicineDentistry and Health SciencesUniversity of MelbourneVictorian Comprehensive Cancer CentreMelbourneVictoria 3010Australia Department of Civil Engineering University of BristolBristolBS81TRUK Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Nanshan School Guangzhou Medical UniversityGuangzhouGuangdong 511436China State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing Wuhan UniversityWuhanHubei 430079China GNSS Research Center Wuhan UniversityWuhanHubei 430079China First Clinical School Guangzhou Medical UniversityGuangzhouGuangdong 511436China Preventive Medicine and Public Health Department University of Santiago de CompostelaCIBER de Epidemiología y Salud Pública(CIBERESP)Health Research Institute of Santiago de Compostela(IDIS)Santiago de CompostelaGalicia 15782Spain Southern Medical University GuangzhouGuangdong 510515China

Background:Light at night(LAN)has become a concern in interdisciplinary research in recent *** global interdisciplinary study aimed to explore the exposure-lag-response association between LAN exposure and lung cancer ***:LAN data were obtained from the Defense Meteorological Satellite Program’s Operational Linescan *** of lung cancer incidence,socio-demographic index,and smoking prevalence of populations in 201 countries/territories from 1992 to 2018 were collected from the Global Burden of Disease *** correlation tests and population-weighted linear regression analysis were used to evaluate the correlation between LAN exposure and lung cancer incidence.A distributed lag nonlinear model(DLNM)was used to assess the exposure-lag effects of LAN exposure on lung cancer ***:The Spearman correlation coefficients were 0.286-0.355 and the population-weighted linear regression correlation coefficients were *** adjustment for socio-demographic index and smoking preva-lence,the Spearman correlation coefficients were 0.264-0.357 and the population-weighted linear regression correlation coefficients were *** the DLNM,the maximum relative risk was 1.04(1.02-1.06)at LAN exposure of 8.6 with a 2.6-year lag *** adjustment for socio-demographic index and smoking prevalence,the maximum relative risk was 1.05(1.02-1.07)at LAN exposure of 8.6 with a 2.4-year lag ***:High LAN exposure was associated with increased lung cancer incidence,and this effect had a specific lag *** with traditional individual-level studies,this group-level study provides a novel paradigm of effective,efficient,and scalable screening for risk factors.

关键词： Light at night Satellite imagery lung cancer Distributed lag nonlinear model(DLNM) Melatonin

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Spontaneous coronary artery rupture after lung cancer surgery:A case report and review of literature

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World Journal of Cardiology 2024年第2期16卷 92-97页

作者： Ying-Ding Ruan Jian-Wei Han Department of Thoracic Surgery The First People's Hospital of JiandeJiande 311600Zhejiang ProvinceChina

BACKGROUND Spontaneous coronary artery rupture(SCAR)is a rare and life-threatening complication after lung cancer *** present a case of SCAR following left upper lobectomy,successfully managed through emergency thoracotomy and coronary artery *** SUMMARY A 61-year-old male patient underwent left upper lobectomy and mediastinal lymph node dissection for lung *** surgery was performed using singleport video-assisted thoracoscopic surgery,and there were no observed complications during the ***,19 h after surgery,the patient experienced chest discomfort and subsequently developed severe symptoms,including nausea,vomiting,and a drop in blood *** measures were taken,leading to the diagnosis of *** patient underwent emergency thoracotomy and coronary artery ligation,successfully stopping the bleeding and stabilizing the *** postoperative complications,the patient made a successful recovery and was discharged from the *** SCAR is a rare but life-threatening complication following lung cancer *** thoracotomy has been shown to be a life-saving measure,while stenting is not the preferred initial approach.

关键词： Spontaneous coronary artery rupture lung cancer Surgery Case report

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Identification of novel targets and mechanisms of wogonin on lung cancer,bladder cancer,and colon cancer

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未来食品学报(英文) 2024年第3期4卷 267-279页

作者： Lin Zhou Yunran Hu Changxing Gao Congci Yu Zhiting Sun Weihong Ge Hui Yang Department of Pharmacy Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China China Pharmaceutical University Nanjing Drum Tower Hospital Nanjing 210008China Hospital for Skin Disease Institute of DermatologyChinese Academy of Medical Sciences and Peking Union Medical CollegeNanjing 210042China Department of Scientific Research Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008

Wogonin(WOG)has been demonstrated to have anti-cancer activity,but the mechanisms remain *** this study,new targets of WOG were predicted for lung cancer,bladder cancer,and colon cancer by using bioinformatics *** might primarily suppress cancers via regulating arachidonic acid,Ras,MAPK,linoleic acid,PI3K Akt,and folate biosynthesis pathways.3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium(MTS)assay showed that WOG inhibited the proliferation of A549 ***-time quantitative reverse transcription PCR(RT-qPCR)results indicated that anti-lung cancer effect of WOG was achieved by regulating the expression of 18 target genes,including AKRIBI0,AKRIC3,BDNF,CAVI,CXCL2,CYP2B6,CYP4F3,DAO,EGF,ENO3,IL6,PLA2GlB,PLA2G2F,PLA2G4A,PTGES,SLCOIBI,SLCOIB3,and *** Kaplan-Meier survival curves further confirmed that DAO,PLA2G1B,SLCO1B3 and TFAP2A were essential targets via which WOG affected lung cancer ***,BDNF,FGF2,and PTGS1 were predicted to be the targets via which WOG alleviated cancer proliferation and invasion in bladder *** for colon cancer,WOG might induce autophagy and inhibit proliferation by down-regulating NTF4 and *** study will provide clue for using wOG as a promising antineoplastic agent in basic and translational research,and bring light to the application of herbs containing WOG as food supplements.

关键词： Wogonin Targets lung cancer Bladder cancer Colon cancer

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Different types of tumor microvessels in stageⅠ-ⅢA squamous cell lung cancer and their clinical significance

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World Journal of Clinical Oncology 2024年第5期15卷 614-634页

作者： Marina A Senchukova Evgeniy A Kalinin Nadezhda N Volchenko Department of Oncology Orenburg State Medical UniversityOrenburg 460000Russia Department of Thoracic Surgery Orenburg Regional Cancer ClinicOrenburg 460021Russia Department of Pathology PA Hertzen Moscow Oncology Research CentreBranch of National Medical Research Radiological CenterMoscow 125284Russia

BACKGROUND lung cancer(LC)is the leading cause of morbidity and mortality among malignant *** the diagnosis and treatment of LC remains an urgent task of modern ***,we established that in gastric,breast and cervical cancer,tumor microvessels(MVs)differ in morphology and have different prognostic *** connection between different types of tumor MVs and the progression of LC is not well *** To evaluate the morphological features and clinical significance of tumor MVs in lung squamous cell carcinoma(LUSC).METHODS A single-center retrospective cohort study examined medical records and archival paraffin blocks of 62 and 180 patients with stage I-IIIA LUSC in the training and main cohorts,*** patients underwent radical surgery(R0)at the Orenburg Regional cancer Clinic from May/20/2009 to December/14/*** sections were routinely processed,and routine Mayer's hematoxylin and eosin staining and immunohistochemical staining for cluster of differentiation 34(CD34),podoplanin,Snail and hypoxia-inducible factor-1 alpha were *** morphological features of different types of tumor MVs,tumor parenchyma and stroma were studied according to clinicopathological characteristics and LUSC *** analysis was performed using Statistica 10.0 *** and multivariate logistic regression analyses were performed to identify potential risk factors for LUSC metastasis to regional lymph nodes(RLNs)and disease *** operating characteristic curves were constructed to discriminate between patients with and without metastases in RLNs and those with and without disease *** effectiveness of the predictive models was assessed by the area under the *** was analyzed using the Kaplan-Meier *** log-rank test was used to compare survival curves between patient subgroups.A value of P<0.05 was considered to indicate statistical *** Depending

关键词： lung cancer lung squamous cell carcinoma Tumor microvessels Tumor stroma Regional lymph node metastases Disease recurrence Disease prognosis

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Life Review the Impact of Combined Watson Care Theory Intervention on Psychological Status and Quality of Life in Patients with Terminal lung cancer

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Journal of Biosciences and Medicines 2024年第7期12卷 207-213页

作者： Jing Liu Hang Su Tumor Ward 3 The First Peoples Hospital of Jingzhou Jingzhou China

Objective: To analyze the impact of combined Watson care theory intervention on the psychological state and quality of life in patients with terminal lung cancer. Methods: 72 patients with terminal lung cancer admitted from March 2021 to January 2024 were selected, which were divided into research group (life review combined with Watson care theory intervention) and control group (conventional intervention), with 36 cases each. Compare the nursing effect between the two groups. Results: The anxiety self-rating scale (SAS) and depression self-rating scale (SDS) scores were significantly lower than those of the control group, and the quality of life score was significantly higher than that of the control group (P lung cancer.

关键词： Life Review Watson Theory of Care lung cancer Quality of Life

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Parthenolide enhances the metronomic chemotherapy effect of cyclophosphamide in lung cancer by inhibiting the NF-kB signaling pathway

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World Journal of Clinical Oncology 2024年第7期15卷 895-907页

作者： Zheng Cai Lang Gao Kai Hu Qi-Ming Wang Department of Internal Medicine The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhou 450008Henan ProvinceChina Department of Oncology The No.1 Affiliated Hospital of Yunnan University of Traditional Chinese MedicineKunming 650021Yunnan ProvinceChina

BACKGROUND Parthenolide(PTL),a sesquiterpene lactone derived from the medicinal herb Chrysanthemum parthenium,exhibits various biological effects by targeting NF-kB,STAT3,and other *** has emerged as a promising adjunct therapy for multiple *** To evaluate the in vitro and in vivo effect of PTL on cyclophosphamide(CTX)metronomic *** The cytotoxicity of PTL and CTX on Lewis lung cancer cells(LLC cells)was assessed by measuring cell activity and *** anti-tumor efficiency was evaluated using a tumor xenograft mice model,and the survival of mice and tumor volume were ***,the collected tumor tissues were analyzed for tumor microenvironment indicators and inflammatory *** In vitro,PTL demonstrated a synergistic effect with CTX in inhibiting the growth of LLC cells and promoting *** vivo,metronomic chemotherapy com-bined with PTL and CTX improved the survival rate of tumor-bearing mice and reduced tumor growth ***,metronomic chemotherapy combined with PTL and CTX reduced NF-κB activation and improved the tumor immune microenvironment by decreasing tumor angiogenesis,reducing Transforming growth factorβ,andα-SMA positive *** PTL is an efficient compound that enhances the metronomic chemotherapy effects of CTX both in vitro and in vivo,suggesting its potential as a supplementary therapeutic strategy in metronomic chemotherapy to improve the chemotherapy effects.

关键词： lung cancer Parthenolide Cyclophosphamide Rhythmic chemotherapy NF-κB pathway

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What enlightenment has the development of lung cancer bone metastasis brought in the last 22 years

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World Journal of Clinical Oncology 2024年第6期15卷 765-782页

作者： Yi Chen Xiao-Song Chen Rong-Quan He Zhi-Guang Huang Hui-Ping Lu Hong Huang Da-Ping Yang Zhong-Qing Tang Xia Yang Han-Jie Zhang Ning Qv Jin-Liang Kong Gang Chen Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology Guigang People’s Hospital of Guangxi/The Eighth Affiliated Hospital of Guangxi Medical UniversityGuigang 537100Guangxi Zhuang Autonomous RegionChina Department of Pathology Wuzhou Gongren Hospital/The Seventh Affiliated Hospital of Guangxi Medical UniversityWuzhou 543000Guangxi Zhuang Autonomous RegionChina

BACKGROUND lung cancer bone metastasis(LCBM)is a disease with a poor prognosis,high risk and large patient *** considerable scientific output has accumulated on LCBM,problems have emerged,such as confusing research *** To organize the research frontiers and body of knowledge of the studies on LCBM from the last 22 years according to their basic research and translation,clinical treatment,and clinical diagnosis to provide a reference for the development of new LCBM clinical and basic *** We used tools,including R,VOSviewer and CiteSpace software,to measure and visualize the keywords and other metrics of 1903 articles from the Web of Science Core *** also performed enrichment and proteinprotein interaction analyses of gene expression datasets from LCBM cases *** Research on LCBM has received extensive attention from scholars worldwide over the last 20 *** therapies and immunotherapies have evolved into the mainstream basic and clinical research *** basic aspects of drug resistance mechanisms and parathyroid hormone-related protein may provide new ideas for mechanistic study and improvements in LCBM *** produced molecular map showed that ribosomes and focal adhesion are possible pathways that promote LCBM *** Novel therapies for LCBM face animal testing and drug resistance *** focus should centre on advancing clinical therapies and researching drug resistance mechanisms and ribosome-related pathways.

关键词： lung cancer Bone metastasis Bibliometrics Targeted therapy Immunotherapy Enrichment analysis

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Effect of Climate Change on lung cancer

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Health 2024年第1期16卷 60-71页

作者： Shivansh Sharma East Brunswick High School New Jersey USA

This research paper aims to draw a relationship between lung cancer and climate change. With the rise of climate change in the last few decades, many organizations and people are concerned about the future of the world. Climate change has many side effects, such as air pollution, which can increase the incidence and death rates of lung and bronchus cancer. This paper aims to draw the relationship between climate change factors and lung cancer incidence and mortality rates. The main finding of this analysis was that there is a positive relationship between lung cancer incidence, death rates, and climate change indicators. The findings from this study have the potential to inform targeted public health interventions and policies, emphasizing the need for proactive strategies in mitigating the health impacts of a changing climate. Section 2 of this paper is a literature review and focuses on the findings of other scholars in this field. Section 3 of this paper is Methods and Processes and will highlight the steps used to create the program and get the results. Section 4 of this paper is Results and Analysis, and will go over the results produced by the machine learning algorithm, and will present graphs and visualizations regarding the relationship of the dependent and independent variables. The final section, Section 5, is Limitations and Conclusion, in which we will discuss possible limitations to both my dataset and my model, and will conclude the paper by presenting a big-picture view of these problems in our society.

关键词： cancer lung cancer Climate Change

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Using Cross Entropy as a Performance Metric for Quantifying Uncertainty in DNN Image Classifiers: An Application to Classification of lung cancer on CT Images

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Journal of Biomedical Science and Engineering 2024年第1期17卷 1-12页

作者： Eri Matsuyama Masayuki Nishiki Noriyuki Takahashi Haruyuki Watanabe Faculty of Informatics University of Fukuchiyama Kyoto Japan Graduate School of Radiological Sciences International University of Health and Welfare Tochigi Japan School of Health Sciences Fukushima Medical University Fukushima Japan School of Radiological Technology Gunma Prefectural College of Health Sciences Gunma Japan

Cross entropy is a measure in machine learning and deep learning that assesses the difference between predicted and actual probability distributions. In this study, we propose cross entropy as a performance evaluation metric for image classifier models and apply it to the CT image classification of lung cancer. A convolutional neural network is employed as the deep neural network (DNN) image classifier, with the residual network (ResNet) 50 chosen as the DNN archi-tecture. The image data used comprise a lung CT image set. Two classification models are built from datasets with varying amounts of data, and lung cancer is categorized into four classes using 10-fold cross-validation. Furthermore, we employ t-distributed stochastic neighbor embedding to visually explain the data distribution after classification. Experimental results demonstrate that cross en-tropy is a highly useful metric for evaluating the reliability of image classifier models. It is noted that for a more comprehensive evaluation of model perfor-mance, combining with other evaluation metrics is considered essential. .

关键词： Cross Entropy Performance Metrics DNN Image Classifiers lung cancer Prediction Uncertainty

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