Parthenolide enhances the metronomic chemotherapy effect of cyclophosphamide in lung cancer by inhibiting the NF-kB signaling pathway
作者机构：Department of Internal MedicineThe Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhou 450008Henan ProvinceChina Department of OncologyThe No.1 Affiliated Hospital of Yunnan University of Traditional Chinese MedicineKunming 650021Yunnan ProvinceChina
出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)
年 卷 期：2024年第15卷第7期
页 面：895-907页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by Joint Funding of Yunnan Ministry of Science and Technology,No.2019FF002-048 and Beijing Heathco Clinical Oncology Research Foundation,No.Y-Q201802-048
主 题：Lung cancer Parthenolide Cyclophosphamide Rhythmic chemotherapy NF-κB pathway
摘 要：BACKGROUND Parthenolide(PTL),a sesquiterpene lactone derived from the medicinal herb Chrysanthemum parthenium,exhibits various biological effects by targeting NF-kB,STAT3,and other *** has emerged as a promising adjunct therapy for multiple *** To evaluate the in vitro and in vivo effect of PTL on cyclophosphamide(CTX)metronomic *** The cytotoxicity of PTL and CTX on Lewis lung cancer cells(LLC cells)was assessed by measuring cell activity and *** anti-tumor efficiency was evaluated using a tumor xenograft mice model,and the survival of mice and tumor volume were ***,the collected tumor tissues were analyzed for tumor microenvironment indicators and inflammatory *** In vitro,PTL demonstrated a synergistic effect with CTX in inhibiting the growth of LLC cells and promoting *** vivo,metronomic chemotherapy com-bined with PTL and CTX improved the survival rate of tumor-bearing mice and reduced tumor growth ***,metronomic chemotherapy combined with PTL and CTX reduced NF-κB activation and improved the tumor immune microenvironment by decreasing tumor angiogenesis,reducing Transforming growth factorβ,andα-SMA positive *** PTL is an efficient compound that enhances the metronomic chemotherapy effects of CTX both in vitro and in vivo,suggesting its potential as a supplementary therapeutic strategy in metronomic chemotherapy to improve the chemotherapy effects.
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