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Noninvasive Quantitative Detection Methods of liver fat content in Nonalcoholic fatty liver Disease

Journal of Clinical and Translational Hepatology 2018年第2期6卷 217-221页

作者： Shujing Lv Sushan Jiang Shousheng Liu Quanjiang Dong Yongning Xin Shiying Xuan Medical College of Qingdao University QingdaoShandongChina Digestive Disease Key Laboratory of Qingdao QingdaoShandongChina Central Laboratories Qingdao Municipal HospitalQingdaoShandongChina Department of Gastroenterology Qingdao Municipal HospitalQingdaoShandongChina Department of Infectious Disease Qingdao Municipal HospitalQingdaoShandongChina

Nonalcoholic fatty liver disease(NAFLD)ranges from simple steatosis to NAFLD-related liver cirrhosis and is a main cause of chronic liver *** with nonalcoholic steatohe-patitis and fibrosis are at a great risk of the progression to cirrhosis or hepatocellular carcinoma,both of which are tightly associated with liver-related *** biopsy is still the gold standard for the diagnosis of NAFLD,but some defects,such as serious complications,sampling error and variability in histologic evaluation among pathologists,remain ***,noninvasive,repeatable and accurate diagnostic methods are urgently *** is a well-established and lower-cost imaging technique for the diagnosis of hepatic steatosis,especially suitable for population census,but limited by its low sensitivity to diagnose mild steatosis and being highly *** tomography also lacks the sensitivity to detect mild steatosis and small changes in fat content,and presents a potential radiation *** attenuation parameter based on the FibroScan?technology is a promising tool for noninvasive semiquantita-tive assessment of liver fat content,but the accuracy rate de-pends on the operator's expertise and is affected by age,width of the intercostal space,skin capsular distance and body mass *** resonance imaging and magnetic resonance spectroscopy are regarded as the most accurate quantitative methods for measuring liver fat content in clinical practice,especially for longitudinal follow up of NAFLD *** this review,we mainly introduce the current imaging methods that are in use for evaluation of liver fat content and we discuss the advantages and disadvantages of each method.

关键词： Nonalcoholic fatty liver disease Hydrogen-1 magnetic resonance spectroscopy Noninvasive liver fat content

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Skeletal muscle loss is associated with diabetes in middle-aged and older Chinese men without non-alcoholic fatty liver disease

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World Journal of Diabetes 2021年第12期12卷 2119-2129页

作者： Ling-Yan Chen Ming-Feng Xia Li Wu Qian Li Yu Hu Hui Ma Xin Gao Huan-Dong Lin Department of Geriatrics Zhongshan HospitalFudan UniversityShanghai 200032China Department of Endocrinology Zhongshan HospitalFudan UniversityShanghai 200032China Fudan Institute for Metabolic Diseases Shanghai 200032China

BACKGROUND Skeletal muscle,a key insulin target organ,has been reported to be associated with diabetes mellitus(DM).Compared to non-diabetic patients,diabetic patients have decreased muscle mass and a higher prevalence of sarcopenia,and patients with sarcopenia may be at increased risk of developing *** individuals with nonalcoholic fatty liver disease(NAFLD),sarcopenia is associated with the severity of fibrosis and *** studies have demonstrated that NAFLD is strongly associated with DM and *** To determine the relationship between skeletal muscle mass and DM in Chinese middle-aged and elderly men,and whether the association is affected by *** Skeletal muscle mass was calculated as appendicular skeletal muscle mass(ASM)in kg/body weight×100%.liver fat content(LFC)was measured using a quantitative ultrasound *** As the ASM decreased,fasting blood glucose(FBG),2-h postprandial blood glucose(2hBG),and LFC increased in both genders,as did the prevalence of DM and *** analysis showed that the ASM was negatively correlated with the FBG,2hBG,and *** logistic regression analysis showed that after adjustments,the ASM quartile was negatively associated with the presence of DM in males,but not in *** analysis showed that the ASM quartiles remained negatively correlated with the presence of DM in the non-NAFLD population(including males and females),but no correlation was found between ASM quartiles and the presence of DM in the NAFLD *** stratified by LFC quartiles,ASM was negatively correlated with the presence of DM in the first and second LFC quartiles in *** Skeletal muscle mass loss was shown to be associated with the presence of DM in males,but not in females;NAFLD weakens this *** results suggested that the stratified management of diabetes mellitus should be considered according to skeletal muscle mass and NAFLD.

关键词： Diabetes mellitus liver fat content Non-alcoholic fatty liver disease Skeletal muscle mass

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PNPLA3 I148M is involved in the variability in anti-NAFLD response to exenatide

PNPLA3 I148M is involved in the variability in anti-NAFLD re...

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2020长三角老年医学高峰论坛、浙江省老年医学学术大会、华东老年医学中心联盟会议、浙江省老年医学联盟会议、浙江省老年病专科联盟会议

作者： Yunzhi Chen Xuemei Yan Xiao Xu Shuhua Yuan Fen Xu Hua Liang

Purpose GLP-1 receptor agonists,such as exenatide,have been proven to attenuate nonalcoholic fatty liver disease(NAFLD) in vivo and in ***,the efficiency of exenatide had interindividual ***3 is a major susceptibility gene for NAFLD and its I148 M polymorphism increases the risk of all disorders of the NAFLD *** this variant contributes to variability in exenatide response is still *** PNPLA3 1481 knockin HepG2 cells were constructed using the Cas9/sgRNA *** Red O staining com-bined with TG quantification was used to evaluate lipid *** blotting and qRT-qPCR were conducted,respectively,to measure the protein and mRNA expression of lipid metabolic and endoplasmic reticulum(ER) stress-related inflammatory ***3 I148 M was genotyped in type2 diabetics using Sanger *** exenatide-induced changes in liver fat content and other clinical parameters were compared between PNPLA3 I148 M *** Lipid deposition increased in both PNPLA3 148 I/I and 148 M/M HepG2 cells treated with palmitoleic acid,while cells with 148 M/M had a higher TG content than those with 148 I/***-4 treatment was showed to be more significant in 148 I/I cells than in 148 M/M cells in terms of reducing the intrahepatic fat content,inhibiting SREBP-lc and ER stress-related inflammation,and activating AMPK-ACC lipid oxidation *** patients with type 2 diabetes,24-week treatment with exenatide improved liver fat content in patients carrying PNPLA3 148 I/I better than in patients with 148 M/*** PNPLA3 I148 M might modify the anti-NAFLD response to exenatide.

关键词： NAFLD PNPLA3 I148M GLP-1 receptor agonist liver fat content Type 2 diabetes

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Selection against abdominal fat percentage may increase intramuscular fat content in broilers

Selection against abdominal fat percentage may increase intr...

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第七届中国畜牧科技论坛

作者： L.Leng H.Zhang J.Q.Dong Z.P.Wang X.Y.Zhang S.Z.Wang Z.P.Cao Y.M.Li H.Li Key Laboratory of Chicken Genetics and Breeding Ministry of Agriculture

Excessive abdominal fat content(AFC) has negative impacts on feed efficiency and carcass *** AFC,intramuscular fat content(IMFC) could be a favorable trait,which has a positive impact on meat *** meet consumers’ needs,a long-term goal of broiler breeders is to decrease AFC and improve the IMFC *** current study was designed to investigate the relationship between AFC and IMFC and to compare IMFC,including the pectoral major muscle fat content(PIMFC) and intramuscular fat content of leg muscle(LIMFC),between two broiler lines divergently selected for abdominal fat percentage over 17 *** results showed that there was a significant difference in PIMFC and LIMFC between the two lines in all five generation populations *** birds in the lean line had significantly lower AFC but higher PIMFC and LIMFC than the birds in the fat *** also detected differences in the liver fat content(LFC) between the two lines and the results showed that birds in the fat line had significant higher LFC than birds in the lean *** results indicated that a desirable broiler line with higher IMFC but lower AFC could be obtained by genetic selection.

关键词： abdominal fat content intramuscular fat content liver fat content chicken

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