Noninvasive Quantitative Detection Methods of Liver Fat Content in Nonalcoholic Fatty Liver Disease

作     者：Shujing Lv Sushan Jiang Shousheng Liu Quanjiang Dong Yongning Xin Shiying Xuan 

作者机构：Medical College of Qingdao UniversityQingdaoShandongChina Digestive Disease Key Laboratory of QingdaoQingdaoShandongChina Central LaboratoriesQingdao Municipal HospitalQingdaoShandongChina Department of GastroenterologyQingdao Municipal HospitalQingdaoShandongChina Department of Infectious DiseaseQingdao Municipal HospitalQingdaoShandongChina 

出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)

年 卷 期：2018年第6卷第2期

页      面：217-221页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by a grant from the National Natural Science Foundation of China(No.31770837) 

主　　题：Nonalcoholic fatty liver disease Hydrogen-1 magnetic resonance spectroscopy Noninvasive Liver fat content 

摘      要：Nonalcoholic fatty liver disease(NAFLD)ranges from simple steatosis to NAFLD-related liver cirrhosis and is a main cause of chronic liver *** with nonalcoholic steatohe-patitis and fibrosis are at a great risk of the progression to cirrhosis or hepatocellular carcinoma,both of which are tightly associated with liver-related *** biopsy is still the gold standard for the diagnosis of NAFLD,but some defects,such as serious complications,sampling error and variability in histologic evaluation among pathologists,remain ***,noninvasive,repeatable and accurate diagnostic methods are urgently *** is a well-established and lower-cost imaging technique for the diagnosis of hepatic steatosis,especially suitable for population census,but limited by its low sensitivity to diagnose mild steatosis and being highly *** tomography also lacks the sensitivity to detect mild steatosis and small changes in fat content,and presents a potential radiation *** attenuation parameter based on the FibroScan?technology is a promising tool for noninvasive semiquantita-tive assessment of liver fat content,but the accuracy rate de-pends on the operator s expertise and is affected by age,width of the intercostal space,skin capsular distance and body mass *** resonance imaging and magnetic resonance spectroscopy are regarded as the most accurate quantitative methods for measuring liver fat content in clinical practice,especially for longitudinal follow up of NAFLD *** this review,we mainly introduce the current imaging methods that are in use for evaluation of liver fat content and we discuss the advantages and disadvantages of each method.