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liver fat accumulation measured by high-speed T2-corrected multiecho magnetic resonance spectroscopy can predict risk of cholelithiasis

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World Journal of Gastroenterology 2020年第33期26卷 4996-5007页

作者： Hong Chen Wei-Ke Zeng Guang-Zi Shi Ming Gao Meng-Zhu Wang Jun Shen Department of Radiology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120Guangdong ProvinceChina Department of MR Scientific Marketing Siemens HealthineersGuangzhou 510120Guangdong ProvinceChina

BACKGROUND liver fat accumulation is associated with increased cholesterol synthesis and hypersecretion of biliary cholesterol,which may be related to the development of *** To investigate whether liver fat accumulation measured by high-speed T2-corrected multi-echo magnetic resonance spectroscopy(MRS)is a risk factor for *** Forty patients with cholelithiasis and thirty-one healthy controls were retrospectively *** participants underwent high-speed T2-corrected multi-echo single-voxel MRS of the liver at a 3T MR *** proton density fat fraction(PDFF)and R2 value were *** parameters and waist circumference(WC)were ***’s correlation analysis was used to analyze the relationship between PDFF,R2,and WC *** logistic regression analysis was carried out to determine the significant predictors of the risk of *** operating characteristic curve(ROC)analysis was used to evaluate the discriminative performance of significant *** Patients with cholelithiasis had higher PDFF,R2,and WC values compared with healthy controls(5.8%±4.2%vs 3.3%±2.4%,P=0.001;50.4±24.8/s vs 38.3±8.8/s,P=0.034;85.3±9.0 cm vs 81.0±6.9 cm,P=0.030;respectively).liver iron concentration extrapolated from R2 values was significantly higher in the cholelithiasis group(2.21±2.17 mg/g dry tissue vs 1.22±0.49 mg/g dry tissue,P=0.034)than in the healthy *** was positively correlated with WC(r=0.502,P<0.001)and R2(r=0.425,P<0.001).Multivariate logistic regression analysis showed that only PDFF was an independent risk factor for cholelithiasis(odds ratio=1.79,95%CI:1.22-2.62,P=0.003).ROC analysis showed that the area under the curve of PDFF was 0.723 for discriminating cholelithiasis from healthy controls,with a sensitivity of 55.0%and specificity of 83.9%when the cut-off value of PDFF was 4.4%.CONCLUSION PDFF derived from high speed T2-corrected multi-echo MRS can predict the risk o

关键词： Magnetic resonance spectroscopy Cholelithiasis liver fat accumulation Steatosis Iron

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Duodenal-jejunal bypass reduces serum ceramides via inhibiting intestinal bile acid-farnesoid X receptor pathway

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World Journal of Gastroenterology 2022年第31期28卷 4328-4337页

作者： Zhi-Qiang Cheng Tong-Ming Liu Peng-Fei Ren Chang Chen Yan-Lei Wang Yong Dai Xiang Zhang Department of General Surgery Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Department of Colorectal and Anal Surgery Feicheng Hospital Affiliated to Shandong First Medical UniversityFeicheng 271600Shandong ProvinceChina Department of General Surgery Lincheng People’s HospitalDezhou 253500Shandong ProvinceChina

BACKGROUND Bile acids play an important role in the amelioration of type 2 diabetes following duodenal-jejunal bypass(DJB).Serum bile acids are elevated ***,the clinical relevance is not *** acids in the peripheral circulation reflect the amount of bile acids in the ***,a further investigation of luminal bile acids following DJB is of great *** To investigate changes of luminal bile acids following *** Salicylhydroxamic acid(SHAM),DJB,and DJB with oral chenodeoxycholic acid(CDCA)supplementation were performed in a high-fat-diet/streptozotocininduced diabetic rat *** weight,energy intake,oral glucose tolerance test,luminal bile acids,serum ceramides and intestinal ceramide synthesis were analyzed at week 12 *** Compared to SHAM,DJB achieved rapid and durable improvement in glucose tolerance and led to increased total luminal bile acid concentrations with preferentially increased proportion of farnesoid X receptor(FXR)-inhibitory bile acids within the common *** ceramide synthesis was repressed with decreased serum ceramides,and this phenomenon could be partially antagonized by luminal supplementation of FXR activating bile acid *** DJB significantly changes luminal bile acid composition with increased proportion FXR-inhibitory bile acids and reduces serum ceramide *** observations suggest a novel mechanism of bile acids in metabolic regulation after DJB.

关键词： Bariatric surgery Duodenal-jejunal bypass Farnesoid X receptor Ceramide Bile acids liver fat accumulation

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