Duodenal-jejunal bypass reduces serum ceramides via inhibiting intestinal bile acid-farnesoid X receptor pathway
作者机构：Department of General SurgeryQilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Department of Colorectal and Anal SurgeryFeicheng Hospital Affiliated to Shandong First Medical UniversityFeicheng 271600Shandong ProvinceChina Department of General SurgeryLincheng People’s HospitalDezhou 253500Shandong ProvinceChina
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2022年第28卷第31期
页 面：4328-4337页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
主 题：Bariatric surgery Duodenal-jejunal bypass Farnesoid X receptor Ceramide Bile acids Liver fat accumulation
摘 要：BACKGROUND Bile acids play an important role in the amelioration of type 2 diabetes following duodenal-jejunal bypass(DJB).Serum bile acids are elevated ***,the clinical relevance is not *** acids in the peripheral circulation reflect the amount of bile acids in the ***,a further investigation of luminal bile acids following DJB is of great *** To investigate changes of luminal bile acids following *** Salicylhydroxamic acid(SHAM),DJB,and DJB with oral chenodeoxycholic acid(CDCA)supplementation were performed in a high-fat-diet/streptozotocininduced diabetic rat *** weight,energy intake,oral glucose tolerance test,luminal bile acids,serum ceramides and intestinal ceramide synthesis were analyzed at week 12 *** Compared to SHAM,DJB achieved rapid and durable improvement in glucose tolerance and led to increased total luminal bile acid concentrations with preferentially increased proportion of farnesoid X receptor(FXR)-inhibitory bile acids within the common *** ceramide synthesis was repressed with decreased serum ceramides,and this phenomenon could be partially antagonized by luminal supplementation of FXR activating bile acid *** DJB significantly changes luminal bile acid composition with increased proportion FXR-inhibitory bile acids and reduces serum ceramide *** observations suggest a novel mechanism of bile acids in metabolic regulation after DJB.
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