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COVID-19 and liver dysfunction:Current Insights and Emergent Therapeutic Strategies

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Journal of Clinical and Translational Hepatology 2020年第1期8卷 18-24页

作者： Gong Feng Kenneth I.Zheng Qin-Qin Yan Rafael S.Rios Giovanni Targher Christopher D.Byrne Sven Van Poucke Wen-Yue Liu Ming-Hua Zheng Xi’an Medical University Xi’anChina NAFLD Research Center Department of Hepatologythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly Southampton National Institute for Health Research Biomedical Research Center University Hospital SouthamptonSouthampton General HospitalSouthamptonUK Ziekenhuis Oost-Limburg Department of AnesthesiologyCritical CareEmergency Medicine and Pain TherapyGenkBelgium Department of Endocrinology the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Institute of Hepatology Wenzhou Medical UniversityWenzhouChina Key Laboratory of Diagnosis and Treatment for The Development of Chronic liver Disease in Zhejiang Province WenzhouChina

The outbreak of coronavirus disease 2019(COVID-19),caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has attracted increasing worldwide *** of liver damage or dysfunction(mainly characterized by moderately elevated serum aspartate aminotransferase lev-els)have been reported among patients with ***,it is currently uncertain whether the COVID-19-related liver damage/dysfunction is due mainly to the viral infection per se or other coexisting conditions,such as the use of potentially hepatotoxic drugs and the coexistence of sys-temic inflammatory response,respiratory distress syndrome-induced hypoxia,and multiple organ *** on the current evidence from case reports and case series,this review article focuses on the demographic and clinical characteristics,potential mechanisms,and treatment options for COVID-19-related liver *** review also describes the geo-graphical and demographic distribution of COVID-19-related liver dysfunction,as well as possible underlying mechanisms linking COVID-19 to liver dysfunction,in order to facilitate future drug development,prevention,and control measures for COVID-19.

关键词： COVID-19 liver dysfunction SARS-CoV-2

COVID-19 and liver dysfunction:What nutritionists need to know

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World Journal of Gastroenterology 2022年第15期28卷 1526-1535页

作者： Ming-Ke Wang Xue-Lu Yu Li-Yun Zhou Hong-Mei Si Ju-Fen Hui Deng-Yong Hou Wei-Peng Li Ji-Shun Yang Department of Disease Control and Prevention Naval Medical Center of PLANaval Medical UniversityShanghai 200052China Medical Care Center Naval Medical Center of PLANaval Medical UniversityShanghai 200052China

The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus-2 has brought serious challenges for the medical *** with COVID-19 usually have respiratory ***,liver dysfunction is not an uncommon ***,the degree of liver dysfunction is associated with the severity and prognosis of ***,diagnosis,and treatment of malnutrition should be routinely recommended in the management of patients with COVID-19,especially in those with liver ***,a large number of studies have reported that nutrition therapy measures,including natural dietary supplements,vitamins,minerals and trace elements,and probiotics,might have potential hepatoprotective effects against COVID-19-related liver dysfunction via their antioxidant,antiviral,anti-inflammatory,and positive immunomodulatory *** review mainly focuses on the possible relationship between COVID-19 and liver dysfunction,nutritional and metabolic characteristics,nutritional status assessment,and nutrition therapy to provide a reference for the nutritionists while making evidence-based nutritional decisions during the COVID-19 pandemic.

关键词： COVID-19 SARS-CoV-2 liver dysfunction Nutritional status assessment Nutrition therapy

A Hemophagocytic Lymphohistiocytosis Patient Initiated with Prominent liver dysfunction: a Case Report

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Chinese Medical Sciences Journal 2014年第3期29卷 191-193页

作者： Ming-jun Zhang Yu-lan Liu Department of Gastroenterology Peking University People's Hospital

HEMOPHAGOCYTIC lymphohistiocytosis(HLH)is an aggressive and potentially fatal syndrome that results from inappropriate activation of lymphocytes and *** is characterized by fever,hepatosplenomegaly,cytopenias,hypertriglyceridemia,hypofibrinogenemia,and pathologic findings of hemophagocytosis in the bone marrow or other *** report an adult HLH case admitted to hepatology department.

关键词： hemophagocytic lymphohistiocytosis liver dysfunction

Fournier gangrene in an infant, complicated with severe sepsis and liver dysfunction: A case report

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World Journal of Clinical Cases 2023年第30期11卷 7398-7402页

作者： Ilirjana Bakalli Saimir Heta Ermira Kola Ermela Celaj Department of Pediatrics UHC“Mother Theresa”Tirana 1024Albania Department of Pediatric Surgery UHC“Mother Theresa”Tirana 1024Albania

BACKGROUND Fournier gangrene is a rare,life-threatening infection characterized by necrotizing fasciitis in the perineal,genital and/or lower abdominal *** its rarity,the unfavorable prognosis associated with this disease is dependent on the timing of medical *** SUMMARY A 3-month-old boy was admitted to our pediatric intensive care unit in critical condition after a 5-day history of fever and scrotal erythema with breaching skin lesions and *** ambulatory antibiotic treatment,the child’s clinical condition *** the time of admission,the child had necrotizing scrotal fasciitis that had spread to the *** reanimation,the surgeon decided on an immediate intervention to rule out testicular torsion and to debride the affected *** optimal antibiotic and supportive therapy,the patient developed severe sepsis with liver dysfunction,making treatment more *** Recognizing Fournier gangrene,prompt referral to pediatric surgery,and appropriate antibiotic coverage are critical for avoiding sepsis and multiorgan dysfunction.

关键词： Fournier gangrene Infant Early diagnosis Sepsis liver dysfunction Case report

liver dysfunction-related COVID-19:A narrative review

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World Journal of Meta-Analysis 2023年第1期11卷 5-17页

作者： Taghreed S Saeed Al-Rawi Raid M Al-Ani Department of Biochemistry University of Anbar College of MedicineRamadi City 31001AnbarIraq Department of Surgery/Otolaryngology University of Anbar College of MedicineRamadi City 31001AnbarIraq

The coronavirus 2019 disease(COVID-19)is caused by a novel coronavirus,severe acute respiratory syndrome coronavirus *** disease was designated by the World Health Organization as a pandemic on March 11,2020,which is not seen *** are no classical features among the cases of the disease owing to the involvement of nearly all body tissues by the *** involvement is one of the characteristics of the COVID-19 *** are six possible mechanisms of such involvement:Direct virus injury,drug-induced effect,inflammatory cytokine storm,hypoxia-ischemic destruction,abnormalities in liver function tests,and pre-existing chronic liver *** abnormalities are seen commonly in the severe or critical stage of ***,these abnormalities determine the COVID-19 severity and carry a high rate of morbidity and *** elderly and patients with comorbidities like diabetes mellitus and hypertension are more vulnerable to liver *** issue that needs to be disclosed is the liver manifestations following the COVID-19 vaccination,such as autoimmune *** note,complete vaccination with third and fourth booster doses is necessary for patients with previous chronic liver diseases or those who have been subjected to liver *** review aims to explore the various aspects of liver dysfunction during the COVID-19 course regarding the epidemiological features,predisposing factors,pathophysiological mechanisms,hepatic manifestations due to COVID-19 or following vaccination,role of liver function tests in the assessment of COVID-19 severity,adverse effects of the therapeutic agents for the disease,and prognosis.

关键词： liver dysfunction liver function test SARS-CoV-2 Mortality Critical illness COVID-19

liver dysfunction on admission worsens clinical manifestations and outcomes of coronavirus disease 2019

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2023年第3期1卷 181-187页

作者： Fangying Lu Rong Chen Kandi Xu Jie Huang Dexiang Yang Tao Bai Yusang Xie Yun Ling Kui Liu Wei Du Jiayang Yan Huihuang Lin Jian Li Yun Feng Min Zhou Yi Guo Department of Respiratory and Critical Care Medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Institute of Respiratory Diseases Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Critical Medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Respiratory Diseases Tongling People’s HospitalTonglingAnhui 244099China Department of Infectious Disease Wuhan Jinyintan HospitalWuhanHubei 430048China Department of Infectious Disease Shanghai Public Health Clinical CenterShanghai 200025China Department of Respiratory and Critical Care Medicine Tongji HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhanHubei 430030China Clinical Research Center Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Background:liver dysfunction was common in coronavirus disease 2019(COVID-19),but its association with clinical features and poor prognosis has not been fully *** study aimed to determine the role of liver dysfunction in COVID-19 and understand the predictors for worse outcomes in patients with liver ***:We conducted this multicenter,retrospective study in five designated hospitals for COVID-19 ***-confirmed COVID-19 patients were enrolled and classified into the normal live function group and liver dysfunction group according to liver enzymes,bilirubin,and albumin on admission,*** of baseline,clinical manifestations,and outcomes were collected and compared in the paired ***:Of the 649 included COVID-19 patients,200(30.8%),69(10.6%),and 267(41.1%)patients had elevated liver enzymes,increased bilirubin,and low-level albumin,***,cough,and dyspnea were the most common symptoms and showed an increased proportion in the liver dysfunction *** with patients in the normal liver function group,patients with liver dysfunction manifested decreased lymphocytes,higher level of leukocytes,neutrophils,inflammatory indicators,and cytokines,as well as more severe impairment in kidney function and *** were more likely to show bilateral involvement and more pulmonary lobes involved according to chest *** increased proportion of patients who developed severe/critical conditions and needed mechanical ventilation and systemic glucocorticoid therapy,patients with liver dysfunc-tion on admission showed significantly higher in-hospital ***,cardiac troponin I≥1.5 ng/mL was identified as an independent mortality predictor in the elevated liver enzymes ***:Patients with liver dysfunction on admission had worse clinical manifestation,and resulted in higher rate of severe/critical type,receiving mechanical ventilation and in-hospital mortality.

关键词： COVID-19 liver dysfunction Clinical manifestation Outcomes Mortality

Risk factors for post-hepatectomy liver dysfunction in primary liver cancer patients with concurrent hepatic schistosomiasis and chronic hepatitis

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Journal of Medical Colleges of PLA(China) 2013年第4期28卷 206-218页

作者： ZHANG Minfeng SHEN Weifeng ZHONG Wei LIU Qu SHEN Rongxi YANG Jiamei Department of Special Treatment Eastern Hepatobiliary Hospital Second Military Medical University Renji Hospital Shanghai Jiaotong University School of Medicine

Objective:The purpose of this study was to analyze risk factors for development of post-hepatectomy liver dysfunction in primary liver cancer(PLC)patients with concurrent hepatic schistosomiasis and chronic ***:A retrospective analysis of 73 PLC patients with concurrent hepatic schistosomiasis and chronic hepatitis,of which 16 patients developed liver dysfunction(persistent ascites or pleural effusion or occurrence of liver-related potentially fatal complications)following hepatectomy,was *** clinical characteristics were recorded,preoperative liver function parameters and surgery-related parameters in these patients were *** potential risk factors for post-hepatectomy liver dysfunction were *** association between these potential risk factors and post-hepatectomy liver dysfunction then was ***:Univariate analysis showed that liver cirrhosis,intraoperative blood loss,and preoperative total bilirubin were associated with the development of post-hepatectomy liver *** logistic regression analysis of these three factors revealed that intraoperative blood loss≥600 mL and cirrhosis were two independent risk factors for post-hepatectomy liver dysfunction in PLC patients with concurrent hepatic schistosomiasis and chronic ***:Keeping intraoperative blood loss below 600 mL can help avoid the development of post-hepatectomy liver dysfunction in liver cancer patients with concurrent hepatic schistosomiasis and chronic *** patients with concomitant liver cirrhosis,every effort should be made to minimize potential liver function impairment induced by other adverse factors.

关键词： Hepatic schistosomiasis Chronic hepatitis Primary liver cancer Hepatectomy liver dysfunction

Association between macronutrients intake and liver dysfunction among tuberculosis patients in Shandong Province

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Association between macronutrients intake and liver dysfunct...

Population Pharmacokinetic Model-guided Optimization of Intravenous Voriconazole Dosing Regimens in Critically Ill Patients with liver dysfunction

中国营养学会第十五届全国营养科学大会

作者： Liangjie Zhao Yue Li Shanliang Zhao Jing Cai Aiguo Ma Qingdao University Linyi People's Hospital

Tuberculosis patients with liver dysfunction were detrimental to their treatment and prognosis because of immune dysfunction. Malnutrition played a vital role in liver dysfunction;however, there were only limited data. This study aimed to clarify the association between macronutrients intake and liver dysfunction in tuberculosis patients and to explore a new idea of alleviating liver dysfunction in tuberculosis patients with nutritional improvement. Methods In this cross-sectional study, 3052 active tuberculosis patients aged >18 years were included based on the data from primary tuberculosis clinics in Linyi City, China. Basic information was collected by the baseline questionnaire. Macronutrients intake of tuberculosis patients was assessed by the 24-hour dietary recalls. ALT or AST values were measured using an automatic biochemical analyzer. The subjects were divided into normal liver function group and liver dysfunction group based on ALT or AST values greater than 40 U/L. Results Among all the tuberculosis patients, 439(14.4%) had liver dysfunction. The patients with liver dysfunction were more likely to be male, less education and higher alcohol intake among drinkers compared to patients with normal liver function. About the daily intake of macronutrients, compared to normal liver function group, patients with liver dysfunction had significantly less protein(P = 0.008), and fat(P liver dysfunction(all P-trend liver dysfunction whether age, gender, education and

关键词： macronutrients intake liver dysfunction tuberculosis patients

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Population Pharmacokinetic Model-guided Optimization of Intr...