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Transactions of Tianjin University 2013年第4期19卷 248-254页

作者：刘宪华杨娇凤张林刘洪喜鲁逸人 School of Environmental Science and Engineering Tianjin University Tianjin Binhai Environmental Industry Development Co. Ltd.

lipoic acid (LA) has received great attention in the area of gold surface functionalization. In this study, LA was employed as a linker for the attachment of antibody to the gold surface of surface plasmon resonance (SPR) chip. By using this chip in a homemade SPR immunosensor, low molecular weight compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) can be detected at a low level of 0.01 ng/mL. There is a good linear relationship(R2 =0.943 1) between the results of SPR biosensor and enzyme-linked immunosorbent assay(ELISA).

关键词： lipoic acid self-assembled monolayer 2,3,7,8-TCDD

Effect of SP-A/B in lipoic acid on acute paraquat poisoning

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World Journal of Emergency Medicine 2014年第1期5卷 57-62页

作者： Shou-peng Li Ji-yuan Han Peng Sun Guo-yan Wu Xiang-yan Bai Department of Emergency Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology

BACKGROUND: This study was undertaken to observe the concentration of SP-A/B and the pulmonary surfactant in the lung tissue of rats with acute lung injury/acute respiratory distress syndrome caused by paraquat poisoning after the treatment of metabolic antioxidant-lipoic acid and whether its influence was related to TNF-α.METHODS: Sixty-six male Sprage-Dawley rats were randomly divided into three groups: normal control group(NS group), 6 rats; paraquat poisoning group(PQ group), 30 rats; and paraquat+lipoic acid treatment group(LA group), 30 rats. The rats in the PQ and LA groups were subdivided into 3-, 6-, 12-, 24-, 48-hour subgroups, with 6 rats in each group. After the rats were sacrificed, lung tissue from the same part was taken from the rats. After HE staining, histological changes were observed in the tissue under a light microscope. Lung tissue was also taken to test the levels of superoxide dismutase(SOD) and malondialdehyde(MDA). Whole blood(0.8 mL) without anticoagulant was drawn from the tail vein of rats for the determination of the TNF-α level. The total RNA of the lung tissue was collected, and the Rt-PCR method was used to measure the levels of SP-A and SP-B ***: HE staining showed that histopathological changes were milder in the LA group than in the PQ group. There were significant differences in MDA and SOD levels between different intervals both in intergroups and intragroups except the 3-hour subgroup(Plipoic acid in acute paraquat poi

关键词： lipoic acid Paraquat Acute lung injury Surfactant protein Tumor necrosis factor-α Oxygen free radical Superoxide dimutase Malonaldehyde

Pharmacokinetics of lipoic acid in healthy Chinese volunteers after single and multiple doses of lipoic acid dispersible tablets

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Journal of Chinese Pharmaceutical Sciences 2015年第5期24卷 336-341页

作者：赵恒利曹若明方增军王海生山东大学第二医院山东济南250033 济南市疾病预防控制中心山东济南250021

This study aimed to evaluate the pharmacokinetics for lipoic acid （LA） after oral administration of 12 healthy Chinese volunteers with single and multiple-dose of lipoic acid dispersal tablets using a liquid chromatography-temdend mass spectrometry （LC-MS/MS） methods. In single-dose study, healthy Chinese male and female volunteers received three dose levels at 0.2, 0.3, and 0.4 g of LA dispersal tablets with a 3 x3 Latina square design. In multiple-dose study, 12 healthy Chinese volunteers received orally a 0.1 g of LA dispersible tablet three times daily for 6 consecutive days and 0.3 g once on day 7. The results showed that pharmacokinetics of LA fitted a two-compartment open model. The values of area under the curve （A UC） increased proportionally within the range of 0.2-0.4 g, while the Vd/F, CL/F, MRT, t1/2 and tmax of LA were similar at three dose levels. The steady-state pharmacokinetic parameters of LA were similar to those following a single dose and no accumulation was found following multiple-dose of LA dispersal tablets.

关键词： lipoic acid Pharmacokinetics LC-MS/MS Drug accumulation

Dose-effect Study of lipoic acid Supplementation on Growth Performance in a Weaned Rat Model

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Journal of Animal Science and Biotechnology 2011年第1期2卷 27-34页

作者： Pengfei Han Jingdong Yin Pingli He Xi Ma State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University Beijing 100193 China

The present study investigated the doseeffect relationship of graded levels of lipoic acid supplementation on growth performance and small intestinal development in a weaned rat model. Seventy-two weaned Sprague-Dawley rats, were fed semipurified diets （ n = 12 ）, either unsupplemented （ group I） or supplemented with 12.5,25,125, or 250 mg/kg body weight （ BW ） lipoic acid （ groups HI, IV, V, and VI）, with 200 mg/kg BW aureomycin as the antibiot- ic control （ group II）. The experiment lasted 21 days. Growth performance was not significantly different （P 〉 0.05） between rats under the antibiotic control （group I） and rats fed low levels （12. 5 and 25 mg/kg BW） of lipoic acid （groups III and IV）. In contrast,high level （125 and 250 mg/kg BW） lipoic acid supplementation （groups V and VI）（P 〈 0.05 ） reduced weight gain, feed consumption, and feed efficiency. In addition, high levels （125 and 250 mg/kg BW） of lipoic acid significantly （P 〈 0.05） reduced the villus height/crypt depth ratio, as well as the numbers of lactobacillus, total aerobes, and total anerobes in the gastrointestinal tract compared with the other treatments, which meant that high levels of lipoic acid impaired intestinal morphology and disordered the balance of intestinal microbiology. Furthermore,the results showed that high levels of lipoic acid supplementation （ P 〈 0.05 ） elevated interferon- γ and interleukin-2, but dramatically （ P 〈 0.05 ） depressed interleukin-4 and interleukin-10 compared with the low levels of lipoic acid supplementation and the control group, which indicated that high levels of lipoic acid would induce bias of Th1/Th2 lymphocytes. Taken together, the results indicate that lipoic acid supplementation can＇ t improve growth performance and intestinal development of normal animals, especially,high levels （ ≥ 125 mg/kg BW） of lipoic acid supplementation restrained growth performance and intestinal development, in association with unbalance of certain cytokines.

关键词： cytokine levels growth performance,intestinal microbiology intestinal morphology lipoic acid

Clinical effect of external counterpulsation combined with lipoic acid on patients with type 2 diabetic foot of grade 0-2

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Journal of Hainan Medical University 2021年第17期27卷 21-25页

作者： Ling-Xiao Zhao Ling Wang Yun Liu Ling Li Shaanxi University of Traditional Chinese Medicine Xianyang 712000China Department of Geriatrics Shaanxi Provincial Hospital of traditional Chinese MedicineXi’an 710000China

Objective:To analyze the clinical efficacy and safety of external counterpulsation combined with lipoic acid in the treatment of patients with type 2 diabetic foot of grade ***:62 patients with diabetic foot from January 2019 to October 2020 were selected and divided into control group and external counterpulsation group according to different treatment schemes,31 cases in each *** control group was given intravenous lipoic acid,and the external counterpulsation group was given external counterpulsation combined with intravenous lipoic *** clinical efficacy and adverse reactions of the two groups were compared,and the blood flow parameters,ankle brachial index and common peroneal nerve conduction velocity of the two groups before and after treatment were ***:The total effective rate of the treatment group(93.54%)was significantly higher than that of the control group(48.38%)(Plipoic acid in the treatment of type 2 diabetic foot with grade 0-2 is

关键词： Type 2 diabetic foot External counterpulsation lipoic acid Dorsal artery diameter of foot Ankle brachial index Nerve conduction velocity

Effects of prostaglandin E1 plus methylcobalamin alone and in combination with lipoic acid on nerve conduction velocity in patients with diabetic peripheral neuropathy:a meta-analysis

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Effects of prostaglandin E1 plus methylcobalamin alone and i...

Efficacy and safety of prostaglandin E1 plus lipoic acid combination therapy versus monotherapy for patients with diabetic peripheral neuropathy:a meta-analysis

2016年广东省药师周大会

作者： De-Qi Jiang Ming-Xing Li Yan Wang Yong Wang Department of Pharmacy Zhujiang Hospital of Southern Medical University Department of Biopharmaceutical Yulin Normal University

This report was to evaluate the efficacy of lipoic acid,prostaglandin E1 and methylcobalamin(L+P+M) for the treatment of diabetic peripheral neuropathy(DPN) in comparison with that of prostaglandin E1 plus methylcobalamin(P+M),in order to provide the basis and reference for clinical rational drug *** controlled trials(RCTs) of L+P+M for DPN published up to August 3,2014 were searched.A random or fixed effect model was used to analyse outcomes which were expressed as risk ratios(RRs) or mean difference(MD) with a 95% confidence interval(CI).Eighteen RCTs with 1,410 participants were *** efficacy of L+P+M therapy was significantly better than P+M therapy(fifteen trials;RR 1.32,95% CI 1.24 to 1.41,P<0.00001,2=32%).Compared with P+M therapy,the pooled effects of L+P+M therapy on nerve conduction velocities(NCVs) were(fifteen trials;MD 4.70,95% CI 3.77 to 5.63,P<0.00001,2=79%) for median MNCV,(thirteen trials;MD 4.73,95% CI 3.69 to 5.77,P<0.00001,2=85%) for median SNCV,(sixteen trials;MD 4.22,95% CI 3.32 to 5.12,P<0.00001,2=83%) for peroneal MNCV,(fourteen trials;MD 3.09,95% CI 2.04 to 4.14,P<0.00001,2=82%) for peroneal *** were no serious adverse events associated with drugs intervention.L+P+M therapy was superior to P+M therapy for improvement of clinical efficacy and NCVs in *** findings should be further verified by high-quality RCTs.

关键词： diabetic peripheral neuropathy lipoic acid prostaglandin E1 methylcobalamin nerve conduction velocity meta-analysis

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Efficacy and safety of prostaglandin E1 plus lipoic acid com...

八药理学及毒物学 40.硫辛酸(α-lipoic acid)的临床应用

2017年广东省药师周大会

作者： De-Qi Jiang Ming-Xing Li Yan-Jiao Ma Yan Wang Yong Wang Department of Pharmacy Zhujiang Hospital of Southern Medical University Cultivation Base for Key Laboratory of Conservation and Utilization of Rare and Economic Species at Southeast Guangxi Yulin Normal University Department of Biopharmaceutical School of Life Science and TechnologyYulin Normal University

The aim of this report was to evaluate the efficacy and safety of prostaglandin E1(PGE1) plus lipoic acid(LA) for the treatment of diabetic peripheral neuropathy(DPN) compared with that of PGE1 or LA monotherapy, in order to provide the basis and reference for clinical rational drug use. Randomized controlled trials(RCTs) published up to August 3, 2014 were searched. A random or fixed effect model was used to analyse outcomes expressed as risk ratios(RRs) or mean difference(MD) with a 95% confidence interval(CI). I2 statistic was used to assess heterogeneity. Subgroup and sensitivity analyses were performed. The outcomes measured were as follows: the clinical efficacy, median motor nerve conduction velocity(MNCV), median sensory nerve conduction velocity(SNCV), peroneal MNCV, peroneal SNCV and adverse effects. Thirty-one RCTs with 2676 participants were included. Clinical efficacy of PGE1+LA combination therapy was significantly better than monotherapy(p < 0.00001, RR=1.32, 95% CI 1.26 to 1.38). Compared with monotherapy, PGE1+LA combination therapy led to significant improvements in median MNCV(p < 0.00001, MD=4.69, 95% CI 3.16 to 6.23), median SNCV(p < 0.00001, MD=5.46, 95% CI 4.04 to 6.88), peroneal MNCV(p < 0.00001, MD=5.19, 95% CI 3.71 to 6.67) and peroneal SNCV(p < 0.00001, MD=5.50, 95% CI 3.30 to 7.70). There were no serious adverse events associated with drug intervention. PGE1 plus LA combination therapy is superior to PGE1 or LA monotherapy for improvement of neuropathic symptoms and nerve conduction velocities in patients with DPN. These findings should be further validated by larger well-designed or high-quality RCTs.

关键词： diabetic peripheral neuropathy prostaglandin E1 lipoic acid efficacy meta-analysis

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药学进展 1960年第4期 46-47页

作者：王文华

对肝脏疾病的应用:Rausch氏认为肝性昏迷系丙酮酸氧化不全,则血中丙酮酸含量上升的结果,而硫辛酸为丙酮酸氧化必要的辅酶,因此降低血中氧化不全丙酮酸含量,故可用于肝性昏迷。一、对肝炎肝硬化的治疗:Rausch曾用于急性及慢性肝炎及肝硬... 详细信息

对肝脏疾病的应用:Rausch氏认为肝性昏迷系丙酮酸氧化不全,则血中丙酮酸含量上升的结果,而硫辛酸为丙酮酸氧化必要的辅酶,因此降低血中氧化不全丙酮酸含量,故可用于肝性昏迷。一、对肝炎肝硬化的治疗:Rausch曾用于急性及慢性肝炎及肝硬化等57例,每日硫辛酸1.1—6.6mg静脉注射,自觉症状31例有显著疗效,18例有效,8例无效。疲劳感,晕眩,食欲不振,睡眠障碍等最初注射后2—36时后上述症状略微消失。对慢性肝炎的治疗可改善病情,结果血清白蛋白增加,γ-球蛋白含量降低,以四溴酚酜钠试肝功能改

关键词：病人 lipoic acid

Green synthesis and characterization of palladium nanoparticles and its conjugates from solanum trilobatum leaf extract

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Nano-Micro Letters 2010年第3期2卷 169-176页

作者： Amarnath Kanchana Saveetha Devarajan Senniyanallur Rathakrishnan Ayyappan Department of Biochemistry Sathyabama University Dental College and Hospitals Department of Biotechnology Sathyabama University Department of Microbiology Sathyabama University Dental College and Hospitals

An important area of research in nanotechnology deals with the synthesis of nanoparticles of different chemical compositions,sizes and controlled ***,there is a growing need to develop environmentally benign nanoparticle synthesis in which no toxic chemicals are used in the synthesis *** nanoparticles(Pd Np) are of interest because of their catalytic properties and affinity for *** protocol for the phyto-synthesis of Pd Np under moderate p H and room temperature offers a new means to develop environmentally benign *** trilobatum is enlightened in our present study as it is enriched with phytochemicals to reduce palladium chloride *** MVA a dietary supplement based on the nontoxic chemotherapeutic lipoic acid-palladium complex(LA-Pd) is been hypothesized as the new paradigm of cancer *** forth we successfully conjugated lipoic acid(S-Pd Np-LA) and vitamins(S-Pd Np-Vitamin-LA) to palladium nanoparticles synthesised from Solanum trilobatum leaf *** nanoparticles(S-Pd Np,S-Pd Np-LA,S-Pd Np-Vitamin-LA) were characterized with UV-Vis Spectroscopy,SEM and FTIR analysis,which revealed that S-Pd Np are polydisperse and of different morphologies ranging from 60?70 nm(S-Pd Np),65?80 nm(S-Pd Np-LA) and 75?100 nm(S-Pd Np-Vitamin-LA) in size.

关键词： Nanoparticles Palladium lipoic acid Palladium lipoic acid complex Poly-MVA Green synthesis Solanum trilobatum

Effects of silver nanoparticle size,concentration and coating on soil quality as indicated by arylsulfatase and sulfite oxidase activities

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Pedosphere 2022年第5期32卷 733-743页

作者： Yutong XUE Prashank MISHRA Frieda EIVAZI Zahra AFRASIABI Environmental Studies Concentration Soka University of AmericaAliso Viejo CA 92656(USA) Nicholas School of the Environment Duke UniversityDurham NC 27707(USA) Department of Agriculture and Environmental Sciences Lincoln UniversityJeferson City MO 6510l(USA)

Recently, the nanotechnology industry has seen a growing interest in integrating silver nanoparticles(AgNPs) into agricultural products, which increases soil exposure to these particles. This demands an investigation into the effect of AgNPs on soil health. Changes in soil enzyme activities upon exposure to AgNPs can serve as early indicators of any adverse effects that these particles may have on soil quality. This study aimed to determine the effects of AgNP size, concentration, coating, and exposure time on the activities of two sulfur cycle enzymes, arylsulfatase and sulfite oxidase. To investigate the sensitivity of soil enzyme activity to AgNP contamination, silt loam soil samples were treated with 30, 80, and 200 nm-sized AgNPs coated with citrate, lipoic acid,and polyvinylpyrrolidone at 1, 10, and 100 mg Ag kgsoil, with the changes in enzyme activities monitored at 3 h, 3 d, and 30 d after treatment. For comparison, the effects of silver(Ag) ions on the enzyme activities were studied under similar treatment conditions. For most of the concentrations tested, the inhibitory effects of AgNPs on different enzymes differed, with a much stronger effect on sulfite oxidase activity than on arylsulfatase activity. The AgNP concentration and exposure time played much important roles than coating type and particle size in the effects of AgNPs on soil enzyme activities.

关键词： citrate lipoic acid polyvinylpyrrolidone soil health sulfur cycle enzyme