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Cardioprotective effects of Salvia miltiorrhiza Bunge and lignum dalbergiae odoriferae on rat myocardial ischemia/reperfusion injury

Cardioprotective effects of Salvia miltiorrhiza Bunge and Li...

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2015年中国药学大会暨第十五届中国药师周

作者： MU Fei DUAN Jia-lin BIAN Hai-xu YIN Ying ZHU Yan-rong WEI guo GUAN Yue WANG Yan-hua GUO Chao WEN Ai-dong XI Miao-miao Department of Pharmacy Xijing Hospital Fourth Military Medical University

Aim: Salvia miltiorrhiza Bunge（SM） and lignum dalbergiae odoriferae（DO） are both traditional Chinese medicine that have cardioprotective effects. Here, we further examined the combined effects of SM and DO on rat myocardial ischemia/reperfusion injury. The possible mechanism of SM and DO also were elucidated. Material and Methods: DO was divided into aqueous extract of lignum dalbergiae odoriferae（DOW） and lignum dalbergiae odoriferae oil（DOO）. Sprague-Dawley rats were randomized to seven groups: sham group, model group, treatment groups including SM（10 g/kg）, DOW（5 g/kg）, DOO（0.5 ml/kg）, SM+DOW（10 g/kg+5 g/kg）, SM+DOO（10 g/kg+0.5 ml/kg）. Rats were pretreated with homologous drug for 7 days and then subjected to 30 min of ischemia followed by 180 min of reperfusion. Electrocardiogram（ECG） and heart rate were monitored and recorded continuously. At the end of reperfusion, blood samples were collected to determine the serum levels of creatine kinase-MB（CK-MB） and lactate dehydrogenase（LDH）. Hearts were harvested to assess heart-body rate, infarct size and histopathological changes as well. Maximum and minimum effective points were determined by measuring indicators associate with myocardial injury at different time-points of reperfusion（5 min, 15 min, 30 min, 45 min, 60 min, 120 min, 180 min）. The potential therapeutic mechanism of SM and SM+DOO were carried out by detecting superoxide dismutase（SOD）,malondialdehyde（MDA）, tumor necrosis factor-alpha（TNF-alpha） and interleukin 6（IL-6）. Results: The results showed SM and DO can ameliorate cardiac function respectively, and this cardioprotective effect was further strengthened by their combinations. Among all the combinations, SM+DOO showed predominant potential to improve ECG and heart rate, reduce heart-body rate（28.5% ±1.4%, P＜0.01 vs model）and myocardial infarct size（20.96%±1.61%,P＜0.01 vs model, P＜0.05 vs SM）, attenuate histopathological damage, decrease the levels of CK-MB and LDH（P＜0.01 vs model, P＜0.05 vs SM）. The maximum effective points of SM and SM+DOO were

关键词： myocardial ischemia/reperfusion injury Salvia miltiorrhiza Bunge lignum dalbergiae odoriferae the maximum and minimum effective points anti-oxidant anti-inflammatory

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The serum metabolomic study of intervention effects of the traditional Chinese medicine Radix salviae miltiorrhizae and lignum dalbergiae odoriferae in the treatment of myocardial ischemia/reperfusion injury in rats

The serum metabolomic study of intervention effects of the t...

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2016年中国药学大会暨第十六届中国药师周

作者： FEI MU JIALIN DUAN HAIXU BIAN RUI LIN MEINA ZHAO AIDONG WEN YONG YANG MIAOMIAO XI Department of Pharmacy Xijing HospitalFourth Military Medical University Department of Pharmacy Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital

. Radix salviae miltiorrhizae（SM） and lignum dalbergiae odoriferae（DO） are both traditional Chinese medicinal herbs for the treatment of ischemic heart disease and other cardiovascular diseases, but few of literature is about the systematic studies. Sprague-Dawley rats were pretreated with SM, aqueous extract of DO（DOA） and volatile oil of DO（DOO）, either as monotherapy or in combination for 7 days, then subjected to 30 min of ischemia followed by 180 min of reperfusion. Traditional pharmacodynamic evaluation and metabonomics based on gas chromatography/time-of-flight mass spectrometry（GC/TOF-MS） were used to identify the therapeutic effect of these traditional Chinese medicines. The results showed that SM, DOA and DOO ameliorated cardiac function respectively, and this effect was further strengthened by their combinations. Among all combinations, SM+DOO showed predominant potential（P＜0.01） to improve electrocardiogram and heart rate, reduce heart weight index and myocardial infarct size, decrease the levels of CK-MB and LDH. Moreover, metabonomics-based findings such as the principal component analysis（PCA） and partial least squares discriminant analysis（PLS-DA） score plot of metabolic state in rat serum correlated well to the preceding results, confirming that SM+DOO exerted synergistic therapeutic efficacies to exhibit better effect on MI/R injury rats compared with other pretreatment groups. Furthermore, the maximum effective point of SM+DOO was 30 min and the minimum effective point was 180 min. In addition, SM+DOO group markedly（P＜0.01） reduced the number of TUNEL-positive cells, the levels of TNF-α, IL-6 and MDA, while increased the activity of SOD both in serum and tissue. These results indicated that SM+DOO have combined effects that are highly effective than single pretreatment against MI/R injury rats. This effect might be achieved partly through anti-apoptosis, anti-oxidant and anti-inflammatory. Thus SM+DOO might be an effective and promising medicine for both prophylaxis and treatment of ischemic he

关键词： Myocardial ischemia/reperfusion injury Radix salviae miltiorrhizae lignum dalbergiae odoriferae The maximum and minimum effective points Cardioprotection Metabonomics

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Cardioprotective effects and mechanism of Radix salviae miltiorrhizae and lignum dalbergiae odoriferae on rat myocardial ischemia/reperfusion injury

Cardioprotective effects and mechanism of Radix salviae milt...

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中国药学会第十三届青年药学科研成果交流会

作者： Fei Mu JiaLin Duan HaiXu Bian Ying Yin YanRong Zhu Guo Wei Yue Guan YanHua Wang Chao Guo AiDong Wen Yong Yang MiaoMiao Xi Department of Pharmacy Xijing HospitalFourth Military Medical University Department of Pharmacy Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital

Objective Radix salviae miltiorrhizae（SM） and lignum dalbergiae odoriferae（DO） are both traditional Chinese medicinal herbs for the treatment of ischemic heart disease and other cardiovascular diseases,but few of literature is about the systematic studies.Sprague-Dawley rats were pretreated with SM,aqueous extract of DO（DOA） and volatile oil of DO（DOO）,either as monotherapy or in combination for 7 days,then subjected to 30 min of ischemia followed by 180 min of reperfusion.Traditional pharmacodynamic evaluation and metabonomics based on gas chromatography/time-of-flight mass spectrometry（GC/TOF-MS） were used to identify the therapeutic effect of these traditional Chinese medicines.The results showed that SM,DOA and DOO ameliorated cardiac function respectively,and this effect was further strengthened by their combinations.Among all combinations,SM+DOO showed predominant potential（P＜0.01） to improve electrocardiogram and heart rate,reduce heart weight index and myocardial infarct size,decrease the levels of CK-MB and LDH.Moreover,metabonomics-based findings such as the principal component analysis（PCA） and partial least squares discriminant analysis（PLS-DA） score plot of metabolic state in rat serum correlated well to the preceding results,confirming that SM+DOO exerted synergistic therapeutic efficacies to exhibit better effect on MI/R injury rats compared with other pretreatment groups.Furthermore,the maximum effective point of SM+DOO was 30 min and the minimum effective point was 180 min.In addition,SM+DOO group markedly（P＜0.01） reduced the number of TUNEL-positive cells,the levels of TNF-α,IL-6 and MDA,while increased the activity of SOD both in serum and tissue.These results indicated that SM+DOO have combined effects that are highly effective than single pretreatment against MI/R injury rats.This effect might be achieved partly through anti-apoptosis,anti-oxidant and anti-inflammatory.Thus SM+DOO might be an effective and promising medicine for both prophylaxis and treatment of ischemic heart disease.

关键词： Myocardial ischemia/reperfusion injury Radix salviae miltiorrhizae lignum dalbergiae odoriferae The maximum and minimum effective points Cardioprotection Metabonomics

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