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Comparative Ligandomic Analysis of Human Lung Epithelial Cells Exposed to PM2.5

Biomedical and Environmental Sciences 2020年第3期33卷 165-173页

作者： TIAN Hong Akhalesh SHAKYA WANG Feng WU Wei Dong LI Wei School of Public Health Xinxiang Medical UniversityXinxiang 453003HenanChina Bascom Palmer Eye Institute Department of OphthalmologyUniversity of Miami School of MedicineMiami 33136FloridaUSA Department of Genomic Medicine UT MD Anderson Cancer CenterHouston 77054TXUSA

Objective To investigate whether exposure to particulate matter of diameter equal to or less than 2.5μm(PM2.5)alters the response of lung epithelial cells to extrinsic regulation by globally profiling cell surface ligands and quantifying their binding *** Human A549 lung epithelial cells(LECs)were treated with or without *** profiling was applied to these cells for the global identification of LEC-binding ligands with simultaneous quantification of binding *** comparisons of the entire ligandome profiles systematically identified ligands with increased or decreased binding to PM2.5-treated *** We found 143 ligands with increased binding to PM2.5-treated LECs and 404 ligands with decreased *** other ligands showed no change in binding *** example,apolipoprotein E(ApoE),Notch2,and growth arrest-specific 6(Gas6)represent ligands with increased,decreased,or unchanged binding activity,*** ApoE and Gas6 are phagocytosis ligands,suggesting that phagocytic receptors on LECs after stimulation with PM2.5 were differentially upregulated by *** These results suggest that the newly-developed ligandomics is a valuable approach to globally profile the response of LECs to PM2.5 in terms of regulating the expression of cell surface receptors,as quantified by ligand binding *** quantitative ligandome profiling will provide indepth understanding of the LEC molecular response on the cell surface to particulate matter air pollution.

关键词： PM2.5 ligandomics Lung epithelial cell Comparative ligandomics Ligand

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