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The anti-cancerous mechanism of licochalcone a on human hepatoma cell HepG2 based on the miRNA omics

Food Science and Human Wellness 2023年第4期12卷 1136-1148页

作者： Jun Wang Xiuxiu Zhang Zhijing Ni Elnur Elam Kiran Thakur Kexin Li Chuyan Wang Jianguo Zhang Zhaojun Wei School of Biological Food and Environment Hefei UniversityHefei 230601China School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China School of Biological Science and Engineering Ningxia Key Laboratory for the Development and Application of Microbial Resources in Extreme EnvironmentsNorth Minzu UniversityYinchuan 750021China

To explore the function of licochalcone a as an anticancer phytochemical on HepG2 cells and investigate its potential mechanisms,we analyzed the microRNAs(miRNAs)expression profile of HepG2 cells in response to licochalcone a(70μmol/L)in vitro.102 dysregulated miRNAs were detected,and SP1 was expected as the transcription factor that regulates the functions of most screened miRNAs.A sum of 431 targets,the overlap of predicted mRNAs from TargetScan,miRDB,and miRtarbase were detected as the targets for these dysregulated *** signaling pathway was the hub pathway for the targets.A protein-protein interaction network was structured on the STRING platform to discover the hub *** them,PIK3R1,CDC42,ESR1,SMAD4,SUMO1,KRAS,AGO1,*** screened ***,the miRNA-target networks were established to screen key dysregulated *** key miRNAs(hsa-miR-133b and hsa-miR-145-5p)were ***,the miRNA-target-transcription factor networks were constructed for these key *** networks for these key miRNAs included three and two transcription factors,*** identified miRNAs,transcription factors,targets,and regulatory networks may offer hints to understand the molecular mechanism of licochalcone a as a natural anticarcinogen.

关键词： licochalcone a HepG2 cells Dysregulated miRNAs Transcription factors Targets Regulatory networks

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 85-94页

作者： Iffat Ara Rita Turcio Tasmia Islam Md.Sabbir Hossain Md.Kamrul Hasan Department of Biochemistry and Molecular Biology Tejgaon CollegeNational UniversityGazipur-1700Bangladesh Department of Pharmacy University of Naples Federico IIvia Domenico Montesano49-80131 Napoli NAItaly Department of Genetic Engineering and Biotechnology Jashore University of Science and TechnologyJashore-7408Bangladesh Department of Public Health North South UniversityDhaka-1229Bangladesh

Background:licochalcone a(LCA)is a flavonoid derived from the roots of Glycyrrhiza uralensis *** DC and other related *** natural source has been extensively used in complementary medicine,especially traditional Chinese medicine,to treat various *** as a phenolic chalcone compound,LCA has gained significant attention in recent years due to its various pharmacological ***:The objective of this review article is to assess the anti-aging ralated pharmacological properties of ***:An exhaustive search of several scientific databases was conducted using various relevant keywords to write this review article on LCA,focusing on its therapeutic applications and anti-aging-related pharmacological *** inclusion and exclusion criteria were strictly followed to retrieve updated relevant ***:A collection of 292 papers were screened,and 131 were included in this review for an in-depth analysis of licochalcone a,focusing on its anti-aging-related pharmacological activities and relevant mechanisms,and its toxicity and side ***,the potential of LCA as a pharmacological product is discussed,emphasizing its health benefits and potential as a pharmaceutical ***:These findings indicate that licochalcone a is a promising natural therapeutic agent for anti-aging therapy and other ailments.

关键词： licochalcone a Glycyrrhiza uralensis Chalcone Anti-aging Neuroprotective Antioxidant Skin protection Therapeutic agent

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Chemical Constituents from Turnip and Their Effects on α-Glucosidase

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Phyton-International Journal of Experimental Botany 2020年第1期89卷 131-136页

作者： Swastika Paul Xuemei Zhang Yongping Yang Changan Geng State Key Laboratory of Phytochemistry and Plant Resources in West China Yunnan Key Laboratory of Natural Medicinal ChemistryKunming Institute of BotanyChinese Academy of SciencesKunming650201China Key Laboratory of Biodiversity and Biogeography Institute of Tibetan Plateau Research at KunmingKunming Institute of BotanyChinese Academy of SciencesKunming650201China University of Chinese Academy of Sciences Beijing100049China

Brassica rapa ***(turnip)is an important crop in Qinghai-Tibet Plateau(QTP)with anti-hypoxic *** is rich in glucosinolates,isothiocyanates and phenolic compounds with diverse biological activities,involving anti-oxidant,anti-tumor,anti-diabetic,anti-inflammatory,anti-microbial,hypolipidemic,cardioprotective,hepatoprotective,nephroprotective and analgesic *** this study,the ethyl acetate(EtOAc)and butanol parts of Brassica rapa were first revealed with inhibitory effects onα-glucosidase,whereas the water part was *** bioassay-guided isolation on the EtOAc and butanol parts yielded 12 compounds,involving three indole derivatives,indole-3-acetonitrile(1)4-methoxyindole-3-acetonitrile(2)and indole-3-aldehyde(3)two flavonoids,liquiritin(4)and licochalcone a(5)two phenylpropanoids,sinapic acid(6)and caffeic acid(7)two phenylethanol glycosides,2-phenylethylβ-glucopyranoside(8)and salidroside(9)and three other compounds,syringic acid(10)adenosine(11)and(3β,20E)-ergosta-5,20(22)-dien-3-ol(12)licochalcone a(5)and caffeic acid(7)showedα-glucosidase inhibitory activity with IC 50 values of 62.4±8.0μM and 162.6±3.2μM,comparable to the positive control,acarbose(IC 50=142±0.02μM).Docking study suggested that licochalcone a(5)could well align in the active site ofα-glucosidase(docking score=-52.88)by forming hydrogen bonds(Gln1372,Asp1420,Gln1372,Arg1510),hydrophobic effects(Tyr1251,Tyr1251,Trp1355,Phe1560,Ile1587,Trp1355,Phe1559,Phe1559)andπ-πstacking interaction(Trp1355).This study provides valuable information for turnip as a new resource in searching anti-diabetic candidates.

关键词： Brassica rapa turnip α-glucosidase licochalcone a docking study

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