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Automatic leukaemia Segmentation Approach for Blood Cancer Classification Using Microscopic Images

Computers, Materials & Continua 2022年第11期73卷 3629-3648页

作者： Anuj Sharma Deepak Prashar Arfat Ahmad Khan Faizan Ahmed Khan Settawit Poochaya School of Computer Applications Lovely Professional UniversityPhagwara144411India School of Computer Science&Engineering Lovely Professional UniversityPhagwara144411India Suranaree University of Technology Nakhon Ratchasima30000Thailand COMSATS University Lahore 54000Pakistan

leukaemia is a type of blood cancer that is caused by undeveloped White Blood Cells(WBC),and it is also called a blast blood *** the marrow of human bones,leukaemia is developed and is responsible for blood cell generation with leukocytes and WBC,and if any cell gets blasted,then it may become a cause of ***,the diagnosis of leukaemia in its early stages helps greatly in the treatment along with saving human ***,in terms of detection,image segmentation techniques play a vital role,and they turn out to be the important image processing steps for the extraction of feature patterns from the Acute Lymphoblastic leukaemia(ALL)type of blood ***,the image segmentation technique focuses on the division of cells by segmenting a microscopic image into background and cancer blood cell nucleus,which is well-known as the Region Of Interest(ROI).As a result,in this article,we attempt to build a segmentation technique capable of solving blood cell nucleus segmentation issues using four distinct scenarios,including K-means,FCM(Fuzzy Cmeans),K-means with FFA(Firefly Algorithm),and FCM with ***,we determine the most effective method of blood cell nucleus segmentation,which we subsequently use for the leukaemia classification ***,using the Convolution Neural Network(CNN)as a classifier,we developed a leukaemia cancer classification model from the microscopic *** proposed system’s classification accuracy is tested using the CNN to test the model on the ALL-IDB dataset and equate it to the current state of the *** terms of experimental analysis,we observed that the accuracy of the model is near to 99%,and it is far better than other existing models that are designed to segment and classify the types of leukaemia cancer in terms of ALL.

关键词： leukaemia blood cell nucleus image segmentation HOG descriptor K-means FCM CNN microscopic images

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Study of Aldo-keto Reductase 1C3 Inhibitor with Novel Framework for Treating leukaemia Based on Virtual Screening and In vitro Biological Activity Testing

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Chemical Research in Chinese Universities 2021年第3期37卷 778-786页

作者： LIU Fei LI Ren YE Jing REN Yujie TANG Zhipeng LI Rongchen ZHANG Cuihua LI Qunlin School of Chemical and Environmental Engineering Shanghai Institute of TechnologyShanghai201418P.R.China

Aldo-keto reductase 1C3(AKR1C3)is a potential target for the treatment of acute myeloid leukaemia and T-cell acute lymphoblastic *** this study,pharmacophore models,molecular docking and virtual screening of target prediction were used to find a potential AKR1C3 ***,eight bacteriocin derivatives(Z1-Z8)were selected as training sets to construct 20 pharmacophore *** best pharmacophore model MODEL_016 was obtained by Decoy test(the enrichment degree was 21.5117,and the fitting optimisation degree was 0.9668).Secondly,MODEL_016 was used for the virtual screening of ZINC ***,the hit 83256 molecules were docked into the AKR1C3 *** to the total scores and interactions between compounds and protein,16532 candidate compounds with higher docking scores and interactions with important residues PHE306 and TRP227 were ***,eight compounds(A1-A8)that had good absorption,distribution,metabolism,excretion and toxicity(ADMET)properties were obtained by target *** A3 and A7 with high total score and good target prediction results were selected for in vitro biological activity test,whose IC_(50) values were 268.3 and 88.94µmol/L,*** results provide an important foundation for the discovery of novel AKR1C3 *** research methods used in this study can also provide important references for the research and development of new drugs.

关键词： Virtual screening In vitro biological activity test Absorption,distribution,metabolism,excretion and toxicity(ADMET)prediction Aldo-keto reductase 1C3(AKR1C3)inhibitor leukaemia

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Plasmodium yoelii infection inhibits murine leukaemia WEHI-3 cell proliferation in vivo by promoting immune responses

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Infectious Diseases of Poverty 2018年第1期7卷 472-479页

作者： Zhen-Zhen Tong Zheng-Ming Fang Qi Zhang Yun Zhan Yue Zhang Wan-Fang Jiang Xiao Hou Yong-Long Li Ting Wang Department of Parasitology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Immunology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

Background:leukaemia is a malignant leukocyte disorder with a high fatality rate,and current treatments for this disease are ***,new therapeutic strategies for leukaemia must be *** parasite infection has been shown to be effective at combating certain neoplasms in animal *** study is to demonstrate the anti-leukaemia activity of malaria parasite Plasmodium yoelii(***)infection,.Methods:In this study,the proportion of CD3,CD19,CD11b and Mac-3 cells was analysed by flow cytometry;the levels of IFN-γand TNF-αin individual serum samples were measured by enzyme-linked immunosorbent assay,and the phagocytic activity of macrophages and natural killer(NK)cell activity were measured by flow ***:We found that *** infection significantly attenuated the growth of WEHI-3 cells in *** addition,tumor cell infiltration into the murine liver and spleen was markedly *** also demonstrated that malaria parasite infection elicited anti-leukaemia activity by promoting immune responses,including increasing the surface markers of T cells(CD3)and B cells(CD19);decreasing the surface markers of monocytes(CD11b)and macrophages(Mac-3);inducing the secretion of IFN-γand TNF-α;and increasing NK cell and macrophage ***:Malaria parasite infection significantly decreases the number of myeloblasts and inhibits neoplasm proliferation in *** addition,malaria parasite infection inhibits murine leukaemia by promoting immune responses.

关键词： leukaemia Plasmodium yoelii WEHI-3 cells Anti-leukaemia

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Effect of fibronectin and leukaemia inhibitory factor on matrix metalloproteinases in mouse blastocyst

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Chinese Science Bulletin 2001年第15期46卷 1296-1300页

作者： Jian Zhang Guodong Tie Yujing Cao Enkui Duan Chinese Acad Sci Inst Zool State Key Lab Reprod Biol Beijing 100080 Peoples R China

This study was designed to detect the effects of fibronectin (FN) and leukaemia inhibitory factor (LIF) on matrix metallopoteinases (MMPs) of mouse blastocysts. The experiments comprised four groups: first, blastocysts grew on the dishes with FN-coated; the second, without FN-coated; the third group, without FN coated, but with 20 ng/μL LIF added to culture medium; and the fourth group, with both FN-coated and 20 ng/μL LIF added. Using MMP-2 and MMP-9 primers respectively, the expressions of MMP-2 and MMP-9 were detected by RT-PCR and cloning identification. The results showed that in the first group, MMP-2 and MMP-9 were produced after 12 and 24 h culturing; in the third group, there were both MMP-2 and MMP-9 bands when blastocysts were cultured for 24 h; and in the fourth group, MMP-2 and MMP-9 bands appeared when blastocysts were cultured for 6, 12 and 24 h. But in the second group no MMP-2 or MMP-9 band appeared. These results show that FN may initiate the transcription of MMP-2 and MMP-9 genes

关键词： matrix metalloproteinases fibronectin leukaemia inhibitory factor reverse transcription polymerase chain reaction mouse blastocyst.

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Expression of partial tandem duplication of mixed lineage leukaemia in patients with acute leukaemia and their relatives

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Chinese Medical Journal 2014年第2期127卷 284-289页

作者： He Yi Wang Dongning Li Xudong Hu Yuan Wang Wenwen Huang Renwei Department of Haematology Third Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510630 China

Background Partial tandem duplication of mixed lineage leukaemia （MLL-PTD） is detected both in patients with acute leukemia and in healthy ***,MLL-PTD in relatives of patients with MLL-PTD has not been *** objective of this study was to investigate the expression of MLL-PTD in patients with acute leukemia and in their *** The bone marrow or peripheral blood was collected from patients with acute leukaemia and their *** reverse transcription-polymerase chain reaction （RT-PCR） was applied to detect the mRNA expression of the MLL-PTD fused gene,and further confirm in genomic DNA *** Analysing MLL-PTD in case 1,the patient＇s older brother and his younger brother were positive,while his mother and his son were *** exon type in case 1 was e9/3 fusion,but in his older brother,it was e9/3 and e11/3 fusion,and in his younger brother,it was e9/3,e10/3,and e11/3 ***-PTD in case 2 was negative,but in the patient＇s older sister was positive,and the exon type was e9/3,e10/3,and e11/*** The expression of MLL-PTD was present in cases with acute leukaemia with a single expression ***,various expression types were detected in their healthy ***-PTD can couple with other chromosome aberrations,and its impact on disease prognosis remains to be studied further.

关键词： MLL-PTD leukaemia healthy population transplantation chromosome aberration

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Etoposide-induced apoptosis results in chromosome breaks within the <i>AF</i>9 gene: Its implication in chromosome rearrangement in leukaemia

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Advances in Bioscience and Biotechnology 2012年第6期3卷 686-694页

作者： Cynthia Patricia Nicholas Sai-Peng Sim Faculty of Medicine and Health Sciences Universiti Malaysia Sarawak Kota Samarahan Malaysia

Treatment with etoposide (VP-16) has been associated with translocation of the mixed lineage leukaemia (MLL) gene seen in treatment-related acute myeloid leukaemia (t-AML). Among the different partner genes, AF9 is the most common partner gene of MLL. AF9 shares similar structural element with the MLL gene. Various mechanisms of translocation have been proposed for the MLL gene, including apoptosis, particularly the apoptotic nuclease. In the current study, we show that VP-16 induced cleavage of the AF9 gene in both leukaemic cells and cultured normal blood cell. All the breakpoints were mapped within the BCR1 of the AF9 gene. AF9 cleavages in leukaemic cells were abolished by pre-treatment with caspase inhibitor (Z-DEVD-FMK), suggesting the involvement of caspase-activated DNase (CAD). The absence of AF9 cleavage in K562 cells further supported the involvement of apoptosis. However, AF9 cleavages in cultured normal blood cell were not eliminated by caspase inhibitor. The possible role of CAD and other apoptotic nucleases/effectors that could be involved in AF9 translocation are discussed.

关键词： Etoposide (VP-16) Apoptosis AF9 Chromosome Breaks leukaemia

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Mexican Guidelines for the Diagnosis and Treatment of Chronic Myeloid leukaemia

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Journal of Cancer Therapy 2013年第3期4卷 747-764页

作者： Eduardo Cervera Federico Godínez Rosa Sosa Ramón Rivas Carlos Best Juan Hernández Adrián Morales Hugo Zurita Ivette Carrasco Jorge Cruz álvaro Aguayo José Espinoza Juan Labardini Luis Valero Judith Cruz Diana Arcos Diego Limón Omar López-Navarro Daniela Gordillo-Bastidas Myrna Candelaria Francisco Torres Juan Kassack Oscar de Jesús Pérez Ramírez Jorge Aquino Guillermo Díaz Mariela Cardiel Margarita Rodríguez Patricia Montoya Juan Contreras María Chávez Sandra Chávez David Gómez Olga Cantú Jorge Duque Luis Pita Eduardo Lobato Julio López Antonio López Pedro González Jorge Cortés Haematology and Oncology Department National Institute of Medical and Nutrition Sciences “Dr. Salvador Zubirán” Mexico City Mexico Haematology Deparment from Hospital Juárez Mexico City Mexico Haematology Department Blood Bank and Unit of Aphaeresis General Hospital of Culiacán Health Ministry Culiacán Mexico Haematology Department Bone Marrow Transplant and Blood Bank from Hospital Regional de Alta Especialidad “Dr. Juan Graham Casassus” Villahermosa Mexico Haematology Department Cancerology National Institute (INCan) Mexico City Mexico Haematology Department Cancerology National Institute (INCan) Mexico City Mexico 2Internal Medicine Haematology Hospital ISSSTECALI Tijuana Mexico Haematology Department Centenario Hospital Miguel Hidalgo Health Ministry Aguascalientes Mexico Haematology Department General Hospital of Sonora State Sonora Mexico Haematology Department Hospital Universitario UANL Monterrey Mexico Haematology Haematology Service Hospital General Regional SSG León Mexico Haematology Head of Haematology Service School of Medicine Autonomous University of San Luis Potosí San Luis Potosí Mexico Haematology Hospital “Aranda de la Parra” León Mexico Haematology Hospital General de Especialidades Campeche Mexico Haematology Hospital General de México Mexico City Mexico Haematology Hospital General de Occidente SSA Guadalajara Mexico Haematology Hospital Regional de Alta Especialidad de Oaxaca Oaxaca Mexico Haematology Mérida Clinic Yucatán Mexico Haematology Oncology Unit SSEP Puebla Mexico Hospital Betania Puebla Mexico Hospital of the Poblano Child Puebla Mexico Internal Medicine Haematology Hospital ISSSTECALI Tijuana Mexico leukaemias Clinic at ISSEMyM Toluca Mexico Leukemia Department MD Anderson Cancer Center Houston Mexico Los Mochis General Hospital Sinaloa Mexico Renaissance Clinic Morelia Mexico State Council for AIDS Prevention and Control Chihuahua Mexico Universidad Autónoma de Yucatán Mérida Mexico

Background: This document includes recommendations and guidelines issued by a group of Mexican researchers and specialists gathered in the First National Colloquium for the Diagnosis and Management of Chronic Myeloid leukaemia (CML) by initiative of Instituto Nacional de Cancerología and with the support of the leukaemia Department of the MD Anderson Cancer Center. Mexico lacks of updated information taken from its own reality on the diagnosis and treatment of CML and other haematological disorders;besides, there are no national guidelines. Aim: To publish a consensus document with guidelines for the management of CML adjusted to the national environment and overall characteristics. Method: The participants answered a DELPHI questionnaire about the overall aspects of the disease, aiming to target controversial topics, discuss them in the colloquium, and to agree on the best ones. After those meetings, a final document was drawn up. Results: The group presents recommendations for definition, diagnosis, prognosis, monitoring, and treatment of CML in Mexico. Conclusions: Having consensus guidelines for the clinical management of CML in our country will enable the consensual practice of Mexican specialists regarding the clinical approach to CML, as well as optimize the resources which allow the rational planning of the medical care strategies.

关键词： Chronic Myeloid leukaemia Management Guidelines Diagnosis Treatment.

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国际感染病学（电子版） 2017年第4期6卷 127-140页

作者： Zhijian Li Xingling Sui Xuebo Yang Wen Sun Shandong Science and Technology Press Co. Ltd Jinan 250002 China Beijing splinger medical research institute Beijing 100054 China

Few studies have deeply compared the expression profiles between normal hematopoietic cells and acute myeloid leukaemia(AML) blasts. To reveal the biology of AML, we compared gene expression profiles between normal hematopoietic cells from 38 healthy donors and leukemic blasts(LBs) from 26 AML patients. Normal hematopoietic samples included CD34+ selected cells, unselected bone marrows(BMs), and unselected peripheral bloods(PBs). Gene expression profile of normal hematopoietic cells from healthy donors and LBs from AML patients were compared to identify differentially expressed genes(DEGs). We defined the comparison of LB and unselected BM as experiment 1, LB and CD34+ isolated from BM as experiment 2, LB and unselected PB as experiment 3, as well as LB and CD34+ isolated from PB as experimen4. Then, protein-protein interaction(PPI) network of DEGs was constructed to identify critical genes. Regulatory impac factors(RIF) was used to identify critical transcription factors(TFs) from the differential co-expression network constructed via re-analyzing the microarray profile from the perspective of differential co-expression. GO(Gene Ontology) enrichmen was performed to extract biological meaning. The comparison among the number of DEGs obtained in the four experiments showed LB cells did not tend to differentiation and CD34+ was more similar to cancer stem cells. Based on the results of PP network, CREBBP, F2 RL1, MCM2 and TP53 were respectively the key genes in experiment 1, 2, 3, and 4. For GO analysis, we found that immune response was the common one in these four stages. Our results might provide a platform for determining the pathology and therapy of AML.

关键词： acute myeloid leukaemia bone marrows CD34+ peripheral bloods

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Two new lignans from Dipteronia dyeriana

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Chinese Chemical Letters 2008年第10期19卷 1215-1217页

作者： Rong Guo Min Luo Chun Lin Long Ma Lin Li Zhi Qin Ouyang Yi Ping Zhou Yue Hu Wang Xing Yu Li Ya Na Shi Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China Yunnan Agricultural University Kunming 650201 China Yunnan Laboratory of Pharmacology for Natural Products Kunming Medical College Kunming 650031 China Yunnan Introduction ＆ Propagation Center for Rare ＆ Endangered Plants Kunming 650032 China

A new sesquilignan, 7＇,8＇-didehydroherpetotriol （1）, and a new lignan glycoside, （＋）-isolariciresinol-9＇-O-α-L-rhamnopyra- nosy1-（1→6）-[3-D-glucopyranoside （2）, were isolated from the branches of Dipteronia dyeriana. Their structures were elucidated by spectroscopic methods and chemical evidence. Compound 1 possessed inhibitory activity against human leukaemia K562 cells with an IC50 value of 39 μmol/L.

关键词： Aceraceae Dipteronia dyeriana Lignans Didehydroherpetotriol leukaemia

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The role of cell free DNA and liquid biopsies in haematological conditions

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Cancer Drug Resistance 2020年第3期3卷 521-531页

作者： Nicholas Bingham Andrew Spencer Australian Centre for Blood Diseases Monash UniversityVictoria 3181Australia.

Cell free nucleic acids(CFNAs)are nucleic acids released from cells that circulate within bodily *** advances in molecular techniques have led to the ability to interrogate CFNAs in a clinically meaningful way,for example the identification and assessment of foetal CFNAs in maternal blood,allowing minimally invasive testing for foetal genetic *** majority of CFNAs arise from haemopoietic cells,making it a particularly rich source of genetic information in haematological ***,the innate genetic heterogeneity of haematological malignancies,as epitomised by multiple myeloma,lend itself well to“liquid biopsies”.This approach promises to provide a more wholistic assessment of whole disease genetics,especially when contrasted against the current gold-standard of single site tissue *** review briefly summarises the definitions and physiology of CFNAs,both cell free DNA(cfDNA)and extracellular RNA(exRNA),before exploring the literature surrounding the current and future roles of cfDNA in the haematological malignancies and patient care.

关键词： cfDNA liquid biopsy haematology myeloma lymphoma leukaemia

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