Plasmodium yoelii infection inhibits murine leukaemia WEHI-3 cell proliferation in vivo by promoting immune responses
作者机构：Department of ParasitologySchool of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of ImmunologySchool of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina
出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)
年 卷 期：2018年第7卷第1期
页 面：472-479页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Leukaemia Plasmodium yoelii WEHI-3 cells Anti-leukaemia
摘 要：Background:Leukaemia is a malignant leukocyte disorder with a high fatality rate,and current treatments for this disease are ***,new therapeutic strategies for leukaemia must be *** parasite infection has been shown to be effective at combating certain neoplasms in animal *** study is to demonstrate the anti-leukaemia activity of malaria parasite Plasmodium yoelii(***)infection,.Methods:In this study,the proportion of CD3,CD19,CD11b and Mac-3 cells was analysed by flow cytometry;the levels of IFN-γand TNF-αin individual serum samples were measured by enzyme-linked immunosorbent assay,and the phagocytic activity of macrophages and natural killer(NK)cell activity were measured by flow ***:We found that *** infection significantly attenuated the growth of WEHI-3 cells in *** addition,tumor cell infiltration into the murine liver and spleen was markedly *** also demonstrated that malaria parasite infection elicited anti-leukaemia activity by promoting immune responses,including increasing the surface markers of T cells(CD3)and B cells(CD19);decreasing the surface markers of monocytes(CD11b)and macrophages(Mac-3);inducing the secretion of IFN-γand TNF-α;and increasing NK cell and macrophage ***:Malaria parasite infection significantly decreases the number of myeloblasts and inhibits neoplasm proliferation in *** addition,malaria parasite infection inhibits murine leukaemia by promoting immune responses.
维普期刊数据库