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leptomeningeal carcinomatosis:an unusual cause of headache in bronchial carcinoma

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Chinese Medical Journal 1999年第1期 87-89页

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关键词： cause headache carcinomatosis unusual bronchial leptomeningeal

Spontaneous Pneumocephalus associated with leptomeningeal glioneuronal tumor in an adult;A rare case report

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Journal of Otology 2024年第3期19卷 144-147页

作者： Mohammad H.Shaheen Syed Raza Bassam AlZuraiqi Mohammad Ghazi Abdoh Essam Saleh Otolaryngology Department Hera General HospitalMakkahSaudi Arabia Otolaryngology-Head and Neck Surgery Department King Abdullah Medical CityMakkahSaudi Arabia Neurosurgery Department King Abdullah Medical CityMakkahSaudi Arabia

Objective:To report a rare case of otogenic tension pneumocephalus as a complication of a diffuse leptomeningeal glioneuronal tumor in a patient with a ventriculoperitoneal(V.P.)***:Twenty-three-year-old man with a confirmed diffuse leptomeningeal glioneuronal tumor diagnosis was treated for temporal bone defect and considerable pneumocephalus one year after ***(s):The patient underwent a Transmastoid,retrolabyrinthine *** defect was closed with temporalis facia graft and conchal cartilage as a double-layer closure,and then DuraSeal®was placed over the repaired *** outcome measure(s):Resolution of the ***:There was a significant reduction in the pneumocephalus on the first day ***:Spontaneous or secondary pneumocephalus development should be considered in patients with brain tumors,hydrocephalus,and patients who undergo *** insertion.

关键词： Pneumocephalus Neurotology leptomeningeal

leptomeningeal Carcinomatosis Presenting Early in Non-Small Cell Lung Cancer

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Surgical Science 2011年第8期2卷 427-429页

作者： Ezra N. Teitelbaum Susan M. Hasselquist Imad A. Tabbara Gregory D. Trachiotis 不详

Purpose: We present the case of a patient presenting with altered mental status on post-operative day seven after a diagnostic lung biopsy. The diagnosis of carcinomatous letomeningeal metastasis was confirmed. Methods: We discuss meningeal carcinomatosis in lung cancer, and describe challenges to diagnosis, therapy, and prognosis. Results: A review of the literature describing the clinical and oncologic principles of letomeningeal carcinomatosis in lung cancer is performed. Discussion: leptomeningeal carcinomatosis (LC) occurs in approximately 5% of patients with non-small cell lung cancer and incurs a bleak prognosis. Presenting neurologic symptoms can be varied and diagnosis is confirmed via lumbar puncture and cerebrospinal fluid cytology. Few data exist regarding optimal treatment, although intrathecal chemotherapy has been shown to provide a modest improvement in median survival.

关键词： leptomeningeal Carcinomatosis Lung Cancer

Gastric leptomeningeal carcinomatosis: Multi-center retrospective analysis of 54 cases

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World Journal of Gastroenterology 2009年第40期15卷 5086-5090页

作者： Sung Yong Oh Su-Jin Lee Jeeyun Lee Suee Lee Sung-Hyun Kim Hyuk-Chan Kwon Gyeong-Won Lee Jung Hun Kang In Gyu Hwang Joung-Soon Jang Ho Yeong Lim Young Suk Park Won Ki Kang Hyo-Jin Kim Department of Internal Medicine and Medical Research Center for Cancer Molecular Therapy Dong-A University College of Medicine Division of Hematology/Oncology Department of MedicineSamsung Medical Center Department of InternalMedicine Gyeongsang National University School of Medicine Department of Internal Medicine College of MedicineChung-Ang University

AIM： To identify the clinical features and outcomes of infrequently reported leptomeningeal carcinomatosis （LMC） of gastric ***： We analyzed 54 cases of cytologically confirmed gastric LMC at four institutions from 1994 to ***： The male-to-female ratio was 32：22, and the patients ranged in age from 28 to 78 years （median,48.5 years）. The majority of patients had advanced disease at initial diagnosis of gastric cancer. The clini-cal or pathologic tumor, node and metastasis stage ofthe primary gastric cancer wasin 38 patients （70%）.The median interval from diagnosis of the primarymalignancy to the diagnosis of LMC was 6.3 mo, rang-ing between 0 and 73.1 mo. Of the initial endoscopic f indings for the 45 available patients, 23 （51%） of the patients were Bormann typeand 15 （33%） patientswere Bormann type. Pathologically, 94% of cases proved to be poorly differentiated adenocarcinomas. Signet ring cell component was also observed in 40% of patients. Headache （85%） and nausea/vomiting （58%） were the most common presenting symptoms of LMC. A gadolinium-enhanced magnetic resonance imaging was conducted in 51 patients. leptomeningeal enhancement was noted in 45 cases （82%）. Intrathecal （IT） chemotherapy was administered to 36 patients-primarily methotrexate alone （61%）, but also in combi-nation with hydrocortisone/± Ara-C （39%）. The median number of IT treatments was 7 （range, 1-18）. Concomitant radiotherapy was administered to 18 patients, and concomitant chemotherapy to seven patients. Sev-enteen patients （46%） achieved cytological negative conversion. Median overall survival duration from the diagnosis of LMC was 6.7 wk （95% CI： 4.3-9.1 wk）. In the univariate analysis of survival duration, hemoglobin, IT chemotherapy, and cytological negative conversion showed superior survival duration （P = 0.038, P = 0.010, and P = 0.002, respectively）. However, in our multivariate analysis, only cytological negative conversion was predictive of relatively longer sur

关键词： Carcinomatosis Gastric cancer Intrathecal chemotherapy leptomeningeal

Characteristic analysis of diffuse leptomeningeal glioneuronal tumor misdiagnosed as cryptococcal meningitis in adolescent female

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Journal of Translational Neuroscience 2019年第3期4卷 37-44页

作者： Yi Bao Lei Gao Jing Xiao Huihui Wu Ying Wang Xinyu Du Quanying Liu Department of Neurology Taihe Hospital Affiliated to Hubei University of MedicineShiyanHubei 442000China

Diffuse leptomeningeal glioneuronal tumor(DLGNT)in adolescent female is rare and easy to be misdiagnosed due to its *** article described the characteristics of an adolescent female DLGNT patient with no history of tumor whose first symptoms are headache and vision loss,and analyzed the causes why DLGNT is easy to be misdiagnosed as cryptococcal *** remedies:the adolescent female presented with progressive exacerbations of headache,vomiting and vision loss after general *** monitoring of routine biochemical changes in cerebrospinal fluid(CSF)found abnormal high CSF pressure and protein,repeated examination of antibodies and acid-fast bacilli were negative,and high-throughput pathogen gene examination excluded viral meningitis,tuberculous meningitis and other *** save the optic nerve,the Ommaya capsule was implanted to reduce the intracranial *** diagnostic antifungal treatment,the patient’s condition did not *** identify the etiology,extensive meningeal enhancement was eventually detected by enhanced magnetic resonance imaging(MRI),and highly atypical tumor cells were identified by repeated examination of fresh CSF *** treatment evaluating:for DLGNT,consult *** biopsy and PET-CT(positron emission tomographycomputed tomography)examination were recommended,and intrathecal chemotherapy and whole-brain radiotherapy were performed according to the examination *** the patient’s family refused to have a meningeal biopsy and asked to be released from the ***:the adolescent female without a history of tumor can not rule out the disease,and cryptococcal meningitis also has meningeal *** gold standard for the diagnosis of DLGNT is to find cancer *** is no effective cure for DLGNT,the timely placement of Ommaya sac can significantly improve the quality of the patient’s life,and the active adoption of targeted therapy is expected to exten

关键词： diffuse leptomeningeal glioneuronal tumor(DLGNT) cryptococcal meningitis cytology Ommaya sac targeted therapy

A Novel Combined Approach for Metastatic Breast Cancer with Dural and leptomeningeal Disease with an Impressive Clinical Outcome: A Case Study

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Journal of Cancer Therapy 2018年第3期9卷 274-280页

作者： Julie Taguchi Christopher Duma M. A. Nezami Pacific Medical Center of Hope Fresno USA

Concurrent dural and leptomeningeal metastatic carcinomatosis are very rare and have a poor prognosis. Here we present a woman with advanced estrogen receptor (ER) positive and progesterone receptor (PR) positive breast cancer who presented with leptomeningeal disease. Patient underwent multi targeted epigenetic therapies applied in a protocol called MTET. She continued to respond to the interval treatment, which consisted only of the nutraceutical agents. Here we discuss her case in detail and we believe that such an example might be applied to other patients in this situation resulting clinical improvement and less toxicity.

关键词： Breast Cancer Metastatic leptomeningeal Disease Dural Disease

The role of Epstein-Barr virus in multiple sclerosis:from molecular pathophysiology to in vivo imaging

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Neural Regeneration Research 2019年第3期14卷 373-386页

作者： Yi Guan Dejan Jakimovski Murali Ramanathan Bianca Weinstock-Guttman Robert Zivadinov Buffalo Neuroimaging Analysis Center Department of Neurology Jacobs School of Medicine and Biomedical Sciences University at BuffaloState University of New York Jacobs Comprehensive MS Treatment and Research Center Department of Neurology Jacobs School of Medicine and Biomedical SciencesUniversity at Buffalo State University of New York Department of Pharmaceutical Sciences State University of New York Center for Biomedical Imaging at Clinical Translational Science Institute University at Buffalo State University of New York

Multiple sclerosis(MS) is a disease of the central nervous system characterized by inflammation, demyelination, and neuronal damage. Environmental and genetic factors are associated with the risk of developing MS, but the exact cause still remains unidentified. Epstein-Barr virus(EBV), vitamin D, and smoking are among the most well-established environmental risk factors in MS. Infectious mononucleosis, which is caused by delayed primary EBV infection, increases the risk of developing MS. EBV may also contribute to MS pathogenesis indirectly by activating silent human endogenous retrovirus-W. The emerging B-cell depleting therapies, particularly anti-CD20 agents such as rituximab, ocrelizumab, as well as the fully human ofatumumab, have shown promising clinical and magnetic resonance imaging benefit. One potential effect of these therapies is the depletion of memory B-cells, the primary reservoir site where EBV latency occurs. In addition, EBV potentially interacts with both genetic and other environmental factors to increase susceptibility and disease severity of MS. This review examines the role of EBV in MS pathophysiology and summarizes the recent clinical and radiological findings, with a focus on B-cells and in vivo imaging. Addressing the potential link between EBV and MS allows the better understanding of MS pathogenesis and helps to identify additional disease biomarkers that may be responsive to B-cell depleting intervention.

关键词： Epstein-Barr virus multiple sclerosis meningeal inflammation magnetic resonance imaging leptomeningeal contrast enhancement mononucleosis human endogeneous retrovirus-W B-cells

Intracranial malignant meningioma with cerebrospinal fluid dissemination： a case report

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Chinese Medical Journal 2011年第10期000卷 1597-1599页

作者： PENG Jing LIANG Zhi-gang LI Kun-cheng Department of Radiology Xuanwu Hospital of Capital MedicalUniversity Beijing 100053 China

Malignant meningiomas are uncommon intracranial tumors. The metastasis of malignant meningiomas to distant extracranial sites are well known. However, dissemination of the tumours in the cerebrospinal fluid （CSF） is rare and few cases have been reported. We present a case of histologically proven malignant meningioma with CSF dissemination at the remote intracranial area and into the spinal canal detected with maqnetic resonance imaging.

关键词： malignant meningioma magnetic resonance imaging cerebrospinal fluid metastasis leptomeningeal