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Evaluation of Immunomodulatory Activity of the Herbals Formula Viranur, Turmeric （Curcuma heyneana Val.） and Phyllanthus （Phyllanthus niruri L.） in layer chicken Vaccinated with Avian Influenza

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Journal of Agricultural Science and Technology(A) 2015年第8期5卷 695-702页

作者： Sri Hartati Tri Untari Ida Fitriyani Bambang Sutrisno Department of Veterinary Clinical Science Faculty of Veterinary Medicine Gadjah Mada University Yogyakarta 55281Indonesia Department of Microbiology Faculty of Veterinary Medicine Gadjah Mada University Yogyakarta 55281 Indonesia Department of Pharmacology Faculty of Veterinary Medicine Gadjah Mada University Yogyakarta 55281 Indonesia Department of Pathology Faculty of Veterinary Medicine Gadjah Mada University Yogyakarta 55281 Indonesia

The aim of this research was to know the effect of herbal as immunomodulator on chicken layer vaccinated with avian influenza. A total of 60 chickens were alloted into three treatment groups： control group （KA）, group KB and group KC, with 20 chicken each group. All the chickens were vaccinated with Newcastle disease （ND） in the age of one week, and a week later they were vaccinated with avian influenza （AI）. The chickens in group KB were drunken with herbal solution containing of 5 g turmeric （Curcuma heyneana Val.） and 25 g phyllanthus （Phyllanthus niruri L.） and group KC were drunken with herbal solution containing of 36 g the herbals formula Viranur and 25 g phyllanthus （Phyllanthus niruri L.）, respectively for four weeks. Thirty days after AI vaccinated, all of chicken were weighed and necropsied. Samples from bursa of Fabricius, tymus and spleen were taken for weighing and histopathological examination. The weight indexs of bursa of Fabricius, tymus and spleen were not significantly different between control group and treatment group in the considered statistically significance （P 〉 0.05）, but the treatment groups （KB and KC） had higher weight index. The histopathologically changes of spleen in both control group and treatment groups were not different, although in the group KC, in bursa of Fabricius, there was lymphocyte increase in its lymphoid follicles; and in the group KB and KC, the tymus were more widening in the cortex than medulla. The conclusion of this study showed that the herbals can stimulate lymphocyte activity.

关键词： Herbal immunomodulator histopathologic bursa of Fabricius thymus spleen layer chicken AI.

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Expression of angiogenic factors and plexiform lesions in the lungs of broiler and layer chickens:A comparison

Expression of angiogenic factors and plexiform lesions in th...

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中国畜牧兽医学会兽医病理学分会第二十四次学术研讨会、中国病理生理学会动物病理生理学专业委员会第二十三次学术研讨会、中国实验动物学会实验病理学专业委员会第三次学术研讨会、中国兽医病理学家第三次学术研讨会

作者：应易恬谭勋邵冯金 Department of Veterinary Medicine Zhejiang University

Pulmonary arterial hypertension(PAH) is the major cause of death in fast growing meat-type chickens(broiler chickens).To better understand the pathogenesis of PAH, metabolomics profiling of lung tissues from PAH broilers and age-matched controls was performed using an untargeted metabolomics approach. PAH was induced by excess salt in drinking water. Medial hypertrophy of pulmonary arteries was present in PAH birds as compared with controls. The metabolomics profiles of lung tissues well distinguished PAH broilers from control subjects. Significant changes in the levels of 41 metabolites were detected in PAH vs. normal birds. Aside from the metabolic alterations indicating a status of oxidative stress and inflammation, evidence of reduced cellular uptake of arginine due to increased lysine biosynthesis and of a shift of agrinine metabolism to arginase pathway were observed. In addition, PAH birds showed increased biosynthesis of fatty acids, which may be associated with excessive proliferation of vascular cells during pulmonary vascular remodeling. Furthermore, we observed significant changes in pentose phosphate pathway(PPP) and increased aminomalonic acid in PAH broilers. These results provide additional biochemical insights into the pathogenesis of the PAH. Our data may lead to the development of new strategies to treat PAH in broilers.

关键词： Plexiform lesion Angiogenic factor Endothelial progenitor cell layer chicken Broiler chicken

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Understanding the effects of intramuscular injection and feed withdrawal on Salmonella Typhimurium shedding and gut microbiota in pullets

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Journal of Animal Science and Biotechnology 2022年第1期13卷 123-137页

作者： Nitish Narendra Joat Samiullah Khan Kapil Chousalkar School of Animal and Veterinary Sciences The University of AdelaideRoseworthySouth Australia 5371Australia

Background:Gut microbiota plays a key role in health,immunity,digestion,and production in *** such as environment,diet,diseases,stress,and flock management significantly affect gut microbiota;however,it is not known how potential stressors such as intramuscular injections or feed withdrawal alter the composition of gut microbiota that result in increased the shedding level of foodborne *** the current study,the effects of intramuscular corticosterone injection and feed withdrawal were evaluated to understand their role in Salmonella Typhimurium shedding and changes in the composition of gut microbiota in ***:Salmonella shedding was observed for 8 weeks *** was a significant increase in Salmonella Typhimurium count after intramuscular injection and feed *** Salmonella infected and the negative control groups showed significant differences in the abundance of different genera in gut microbiota at week 1 and up to week 7 post *** infected group showed a significant reduction in alpha diversity of gut *** reduced significantly(P<0.05)after intramuscular injection,while the feed withdrawal groups did not cause any significant changes in Proteobacteria-Firmicutes ***,intramuscular injection resulted in a significant change in alpha diversity of gut ***:Exposure of chicks to relatively low dose of Salmonella Typhimurium can lead to persistent shedding in *** Salmonella Typhimurium infection disrupted the gut microbiota composition immediately after *** potential stress of intramuscular injection and feed withdrawal significantly increased the Salmonella Typhimurium count in *** intramuscular injection also resulted in a significant alteration of the Proteobacteria-Firmicutes ratio,which could increase the risk of dysbiosis.

关键词： Corticosterone injection Feed withdrawal stress Gut microbiota composition layer chicken Salmonella Typhimurium infection

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