Expression of angiogenic factors and plexiform lesions in the lungs of broiler and layer chickens:A comparison
作者单位：Department of Veterinary Medicine Zhejiang University
会议名称：《中国畜牧兽医学会兽医病理学分会第二十四次学术研讨会、中国病理生理学会动物病理生理学专业委员会第二十三次学术研讨会、中国实验动物学会实验病理学专业委员会第三次学术研讨会、中国兽医病理学家第三次学术研讨会》
会议日期：2018年
学科分类：090603[农学-临床兽医学] 09[农学] 0906[农学-兽医学]
基 金：supported by Zhejiang Provincial Natural Science Foundation of China(project no.LR12C18001)
关 键 词：Plexiform lesion Angiogenic factor Endothelial progenitor cell Layer chicken Broiler chicken
摘 要：Pulmonary arterial hypertension(PAH) is the major cause of death in fast growing meat-type chickens(broiler chickens).To better understand the pathogenesis of PAH, metabolomics profiling of lung tissues from PAH broilers and age-matched controls was performed using an untargeted metabolomics approach. PAH was induced by excess salt in drinking water. Medial hypertrophy of pulmonary arteries was present in PAH birds as compared with controls. The metabolomics profiles of lung tissues well distinguished PAH broilers from control subjects. Significant changes in the levels of 41 metabolites were detected in PAH vs. normal birds. Aside from the metabolic alterations indicating a status of oxidative stress and inflammation, evidence of reduced cellular uptake of arginine due to increased lysine biosynthesis and of a shift of agrinine metabolism to arginase pathway were observed. In addition, PAH birds showed increased biosynthesis of fatty acids, which may be associated with excessive proliferation of vascular cells during pulmonary vascular remodeling. Furthermore, we observed significant changes in pentose phosphate pathway(PPP) and increased aminomalonic acid in PAH broilers. These results provide additional biochemical insights into the pathogenesis of the PAH. Our data may lead to the development of new strategies to treat PAH in broilers.