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Evaluation of gastric lavage efficiency and utility using a rapid quantitative method in a swine paraquat poisoning model

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World Journal of Emergency Medicine 2020年第3期11卷 174-181页

作者： Yun-fei Jiang Jian Kang Pei-pei Huang Jia-xi Yao Zhong-he Wang Lei Jiang Jun Wang Li Qiao Bao-li Zhu Hao Sun Jin-song Zhang Department of Emergency the First Affi liated Hospital of Nanjing Medical UniversityNanjingChina Department of Emergency Nanjing Drum Tower Hospitalthe Affi liated Hospital of Nanjing University Medical SchoolNanjingChina Key Lab of Modern Toxicology Ministry of Education and Department of Hygienic Analysis and DetectionSchool of Public HealthNanjing Medical UniversityNanjingChina Key Lab of Modern Toxicology Ministry of Education and Department of ToxicologySchool of Public HealthNanjing Medical UniversityNanjingChina Department of Occupational Disease Prevention Jiangsu Provincial Center for Disease Control and PreventionNanjingChina

BACKGROUND:Gastric lavage(GL)is one of the most critical early therapies for acute paraquat(PQ)poisoning;however,details of the treatment protocol remain to be ***:A rapid quantitative method involving sodium dithionite testing was *** was validated for the determination of the PQ concentrations in gastric juice and eluate samples from a swine acute PQ poisoning model with early or delay GL,or *** vital signs,laboratory testing,and PQ plasma concentrations were collected for therapeutic effect ***:The reaction conditions of the test were optimized for two types of *** GL at one hour(H1)could improve the signs and symptoms after acute PQ poisoning at 24 hours(H24).In contrast,GL at 6 hours(H6)could only partially relieve the vital *** H1 GL group effectively reduced the peak of the plasma PQ *** addition,the PQ concentrations in the plasma and the gastric juice were significantly decreased in both the GL groups as compared to the untreated group at ***,there was no significant difference in the washing efficiencies calculated from the total eluates between the two GL ***,the washing efficiency of the first 10 L eluate is superior to that of the additional 10 L ***:GL only at early stage may it benefit PQ poisoning in an animal *** currently used 20 L GL volume may need to be reduced in view of the low washing efficiency in the later 10 L *** rapid quantitative method can be used for gastric juice sample and has a certain value for clinical GL practices.

关键词： Acute paraquat poisoning Gastric lavage Sodium dithionite test Swine model

Novel abdominal negative pressure lavage-drainage system for anastomotic leakage after R0 resection for gastric cancer

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World Journal of Gastroenterology 2019年第2期25卷 258-268页

作者： Zhi-Fang Zheng Jun Lu Peng-Yang Zhang Bin-Bin Xu Chao-Hui Zheng Ping Li Jian-Wei Xie Jia-Bin Wang Jian-Xian Lin Qi-Yue Chen Chang-Ming Huang Department of Gastric Surgery Fujian Medical University Union Hospital Department of General Surgery Fujian Medical University Union Hospital Key Laboratory of Ministry of Education of Gastrointestinal Cancer Fujian Medical University

BACKGROUND Anastomotic leakage(AL) is a severe complication associated with high morbidity and mortality after radical gastrectomy(RG) for gastric cancer(GC).We hypothesized that a novel abdominal negative pressure lavage-drainage system(ANPLDS) can effectively reduce the failure-to-rescue(FTR) and the risk of reoperation, and it is a feasible management for *** To report our institution's experience with a novel ANPLDS for AL after RG for *** The study enrolled 4173 patients who underwent R0 resection for GC at our institution between June 2009 and December 2016. ANPLDS was routinely used for patients with AL after January 2014. Characterization of patients who underwent R0 resection was compared between different study periods. AL rates and postoperative outcome among patients with AL were compared before and after the ANPLDS therapy. We used multivariate analyses to evaluate clinicopathological and perioperative factors for associations with AL and FTR after *** AL occurred in 83(83/4173, 2%) patients, leading to 7 deaths. The mean time of occurrence of AL was 5.6 days. The AL rate was similar before(2009-2013, period1) and after(2014-2016, period 2) the implementation of the ANPLDS therapy(1.7% vs 2.3%, P = 0.121). Age and malnourishment were independently associated with AL. The FTR rate and abdominal bleeding rate after AL occurred were respectively 8.4% and 9.6% for the entire period; however, compared with period 1, this significantly decreased during period 2(16.2% vs 2.2%, P = 0.041;18.9% vs 2.2%, P = 0.020, respectively). Moreover, the reoperation rate was also reduced in period 2, although this result was not statistically significant(13.5% vs2.2%, P = 0.084). Additionally, only ANPLDS therapy was an independent protective factor for FTR after AL(P = 0.04).CONCLUSION Our experience demonstrates that ANPLDS is a feasible management for AL after RG for GC.

关键词： Gastric cancer Anastomotic leakage Drainage lavage Failure-to-rescue

HPLC Quantification of Dexamethasone Palmitate in Bronchoalveolar lavage Fluid of Rat after Lung Delivery with Large Porous Particles

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American Journal of Analytical Chemistry 2019年第9期10卷 404-414页

作者： Alain N’Guessan Armand Koffi Ismaë l L. Dally Christophe N’Cho Amin Claire Gueutin Nicolas Tsapis Elias Fattal Institute Galien Paris-Sud Paris-Sud University Orsay France School of Pharmacy University Félix Houphouet-Boigny Abidjan C&ocirc te d’Ivoire

A high-performance liquid chromatography (HPLC) method has been developed and validated for the determination of dexamethasone palmitate (DXP) in bronchoalveolar fluid lavage samples (BALF). DXP in rat BALFs containing the internal standard (IS), testosterone decanoate (TD), was extracted using a mixture of chloroform and methanol (9:1, v/v). Extracts were then centrifuged, dried and dissolved in acetonitrile. A chromatographic separation based on an isocratic elution was done using acetonitrile and water (85:15, v/v) as a mobile phase at a flow rate of 1.2 mL/min. The graph of the developed method was linear within the tested calibration range of 0.5 - 40 μg/mL. The overall extraction recovery of DXP from BALF samples was 84.3% ± 1.6%. The accuracy (relative error) and precision (coefficient of variation) values were within the pre-defined limits of ≤15% at all concentrations. This methodology has been applied to determine levels of DXP in BALF samples collected from rats treated with DXP large porous particles. The measured concentrations were successfully evaluated using a non-compartment pharmacokinetic model. Since the developed method requires only a microvolume (100 μL) of BALF sample for analysis, it is therefore particularly suitable for the evaluation of drug biodistribution in lung.

关键词： Dexamethasone Palmitate Bronchoalveolar lavage Fluid HPLC

Arthroscopic Debridement with lavage and Arthroscopic lavage Only as the Treatment of Symptomatic Osteoarthritic Knee

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Open Journal of Clinical Diagnostics 2015年第2期5卷 68-73页

作者： Suhail Karkabi Nahum Rosenberg Shoulder Service Rambam Health Care Campus Haifa Israel

In this prospective follow up study we evaluated and compared the effect of arthroscopic lavage with and without debridement as a treatment of moderately osteoarthritic knees in middle aged and elderly population. The study group comprised of 500 patients (250 patients for each type of treatment, mean age 58 years). The patients were followed six months, three years and six years postoperatively. Following both treatments there was a clear deterioration in function of the knee function over the time, as measured starting at six months follow up until six years postoperatively (p lavage only. We show that for the patients with high functional demand and expectations for long term rehabilitation and improvement both arthroscopic treatments are not satisfactory in more of 60% of cases.

关键词： Arthroscopy Knee Osteoarthritis Debridement lavage

Negative short-term impact of intraoperative biliary lavage in patients with hepatolithiasis

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World Journal of Gastroenterology 2016年第11期22卷 3234-3241页

作者： Ou Jiang Rong-Xing Zhou Ke Yang Chun-Xian Cai Yu Liu Nan-Sheng Cheng Department of Surgical Oncology The Second People’s Hospital of Neijiang Department of Biliary Surgery West China Medical Center of Sichuan University

AIM: To evaluate short-term outcomes following intraoperative biliary lavage for ***: A total of 932 patients who were admitted to the West China Medical Center of Sichuan University between January 2010 and January 2014 and underwent bile duct exploration and lithotomy were retrospectively included in our study. The patients were divided into the lavage group and the control group. Related pre-, intra-, and postoperative factors were recorded, analyzed, and compared between the two groups in order to verify the effects of biliary lavage on the short-term outcome of patients with hepatolithiasis. RESULTS: Amongst the patients who were included, 678 patients with hepatolithiasis were included in the lavage group, and the other 254 patients were enrolled in the control group. Data analyses revealed that preoperative baseline and related intraoperative variables were not significantly different. However, patients who underwent intraoperative biliary lavage had prolonged postoperative hospital stays(6.67 d vs 7.82 d, P = 0.024), higher hospitalization fees(RMB 28437.1 vs RMB 32264.2, P = 0.043), higher positive rates of bacterial cultures from blood(13.3% vs 25.8%, P = 0.001) and bile(23.6% vs 40.7%, P= 0.001) samples, and increased usage of advanced antibiotics(26.3% vs 38.2%, P = 0.001). In addition, in the lavage group, more patients had fever(> 37.5℃, 81.4% vs 91.1%, P = 0.001) and hyperthermia(> 38.5℃,39.7% vs 54.9%, P = 0.001), and higher white blood cell counts within 7 d after the operation compared to the control ***: Intraoperative biliary lavage might increase the risk of postoperative infection, while not significantly increasing gallstone removal rate.

关键词： Hepatolithiasis Biliary lavage Postoperative infection

Five-Year Survivors of Non-Small Cell Lung Cancer Patients with Positive Pleural lavage Cytology

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Advances in Lung Cancer 2014年第1期3卷 21-25页

作者： Masaki Tomita Takanori Ayabe Eiichi Chosa Kunihide Nakamura Department of Surgery II Faculty of Medicine University of Miyazaki Miyazaki Japan

Background: The pleural lavage cytology (PLC) for non-small cell lung cancer (NSCLC) patients has been reported as a significant prognostic factor. The aim of this study is to clarify the clinicopathological characteristics of 5-year survivors of patients with positive PLC. Methods: Among 401 resected NSCLC patients, 30 (7.48%) patients with positive PLC were reviewed retrospectively. Results: Only 7 of 30 patients (23.3%) survived more than 5-year. There were no differences in age, gender, histology, pT status and pN status between 5-year survivors and non-survivors. On the other hand, the serum carcinoembryonic antigen (CEA) level was significantly higher in non-survivors. Among these 5-year survivors, 4 of 7 patients died of NSCLC recurrences more than 5 years after surgery. Remaining 3 patients survived without cancer recurrences. Interestingly these 3 survivors had not received any adjuvant therapies after surgery. Conclusion: None of the 5-year survivor with positive PLC had high serum CEA level. Furthermore 5-year survival did not equal to cure in NSCLC patients with positive PLC.

关键词： Pleural lavage Cytology Positive Non-Small Cell Lung Cancer 5-Year Survivor

Changes of cell factor in bronchoalveolar lavage fluid in rats exposed to silica

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China Medical Abstracts(Internal Medicine) 2014年第1期31卷 9-10页

作者：张玮 Shandong Acad Occup Health & Occup Med

Objective To investigate the changes in the levels of inflammatory cytokines in bronchoalveolar lavage fluid(BALF)in rats exposed to silica *** Experimental rats were randomly divided into control group and three experimental groups(doses of dust:15,30,and 60mg/ml),with 42 rats in each *** rat in the control group was treated with 1 ml of normal saline by intratracheal instillation,while each rat in the experimental groups was exposed to

关键词： lavage exposed silica saline cytokines immunosorbent interleukin doses killed inflammation

Pulsed lavage in Cementless Total Hip Arthroplasty Reduces the Incidence ofBrooker Grade 3 and 4 Heterotopic Ossifications

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Open Journal of Orthopedics 2011年第2期1卷 9-13页

作者： Joris Mellema Wierd Zijlstra Tom van Raaij Bas ten Have Jos van Raay 不详

Heterotopic ossification (HO) may cause pain, and can lead to loss of hip motion after total hip arthroplasty (THA). There is evidence that pulsed lavage may lower the incidence of HO formation. We assessed the effect of pulsed lavage on the incidence of HO in 87 male patients after THA. All patients received an uncemented THA through a posterolateral approach. 39 patients were treated with pulsed lavage (index group) and 48 males were treated without pulsed lavage (historical control group, matched on aetiology, gender, surgical approach and type of prosthesis). Both groups followed the same postoperative treatment regimen. HO severity was scored in both groups according to the Brooker classification by three blinded orthopaedic surgeons one year postoperatively. Good inter-observer agreement (Kappa 0.7) for scoring HO was found. The incidence of HO (51%) in the index group did not differ significantly (p = 0.53) from the control group (58%). However, the incidence of clinically relevant HO (Brooker grades 3 and 4) was significantly lower (p = 0.04) in the index group (3%) as compared to the control group (17%). These results suggest a beneficial effect of pulsed lavage on the incidence of severe heterotopic ossification after cementless THA in male patients.

关键词： Heterotopic Ossification Pulsed lavage Total Hip Arthroplasty Uncemented

Safety of gastric lavage using nasogastric ryle’s tube in pesticide poisoning

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Health 2011年第7期3卷 401-405页

作者： Uday Bhan Bhardwaj Anand Subramaniyan Ashish Bhalla Navneet Sharma Surjit Singh 不详

Objective: Gastric lavage is mandatory irrespective of nature in all patients with acute poisoning in India. Present study was undertaken with aim whether lavage done using nasogastric Ryle’s tube and small aliquots of water or normal saline is safe. Patients and Methods: All the patients above 12 years of age admitted consecutively with pesticide ingestion or exposure between July 2004 to June 2005 were studied with respect to complications associated with lavage using Ryle’s tube. Forty five patients were admitted directly to our hospital and lavage was undertaken using Ryle’s tube (16F ) with 100 - 200 mL of aliquots till 1 - 1.5 liters of fluid was lavaged, with prophylactic endotracheal intubation in patients with Glasgow coma scale ( GCS) lavage in group I was compared to that in 53 patients admitted during same period with pesticide poisoning but lavaged outside using nasogastric Ryle’s tube and referred to our institute (group II). Results: The significant complications observed in group I were significant drop in SaO2 (6 patients) laryngospasm, tachycardia, electrolyte imbalance and tube getting struck in throat (one each). In one patient in group I (had no prophylactic intubation though GCS 3) In group II, 7 had aspiration pneumonia (no prophylactic intubation). Other significant complication was drop in SaO2 during lavage. None of them had any serious life threatening complication. Conclusion: Gastric lavage carried out using nasogastric Ryle’s tube and small aliquots of water or normal saline is relatively safe in patients with pesticide poisoning when combined with prophylactic endotracheal intubation in patients with GCS < 10. In absence of prophylactic intubation, risk of aspiration is there. However aspiration pneumonia is generally mild and not life threatening.

关键词： Pesticide Poisoning Gastric lavage Nasogastric Ryle’s Tube Complications