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Genes & Diseases 2024年第3期11卷 148-150页

作者： Chen Tan Lingwa Wang Yifan Yang Shizhi He George G.Chen Jason YK.Chan Michael CF.Tong C.A.van Hasselt Wenbin Xu Ling Feng Ru Wang Jugao Fang Department of Otolaryngology Head and Neck Surgery Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Key Laboratory of Otolaryngology Head and Neck Surgery(Ministry of Education of China) Beijing Institute of OtolaryngologyBeijing 100730China Department of Otorhinolaryngology Head and Neck SurgeryThe Chinese University of Hong KongPrince of Wales HospitalHongKong SAR999077China Department of Medical Genetics Institute of Basic Medical ScienceChinese Academy of Medical Science&Peking Union Medical CollageBeijing 100730China

Locoregionally advanced laryngeal and hypopharyngeal cancers(LA-LHCs)are traditionally treated with surgery followed by postoperative radiotherapy,which impairs speech and swallowing functions and reduces the quality of life.^(1,2)The use of induction chemotherapy(IC)as a larynxpreserving approach for LA-LHCs has been verified and refined.^(3)However,the short-term tumor response to IC varies,non-responders usually show poor survival and little benefit.

关键词： chemotherapy laryngeal surgery

laryngeal Tuberculosis and laryngeal Cancer: Two Similar Diagnoses in an Elderly Person in Tuberculosis-Endemic Area

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Case Reports in Clinical Medicine 2023年第8期12卷 292-298页

作者： Ndeye Amy Sarr Daouda Thioub Ndiassé Ndiaye Agbogbenkou Tevi Déla Lawson Sylvie Audrey Diop Department of Infectious and Tropical Diseases Abdoul Aziz Sy Dabakh Hospital of Tivaouane Tivaouane Senegal ENT Department Thiès Regional Hospital Thiès Senegal

laryngeal tuberculosis is a rare form of extrapulmonary tuberculosis, often complicating pulmonary tuberculosis that may be unrecognized. Its clinical presentation is nonspecific, often pointing to cancer. We report the case of a 77-year-old woman, with no reported pathological history. She also has no alcohol or tobacco intoxication, who presented with chronic dysphonia evolving for 2 months, associated with an altered general condition. The examination of the larynx by direct laryngoscopy and anatomical pathology study of the biopsies led to the diagnosis of laryngeal tuberculosis. A search for secondary sites revealed a concomitant pulmonary infection. The evolution was favorable under standard anti-tuberculosis treatment, with complete voice recovery and improved performance status. laryngeal tuberculosis should be suspected in patients living in endemic areas and suffering from chronic dysphonia, even if they are not alcoholics or smokers.

关键词： Tuberculosis laryngeal Dysphonia Senegal

Efficacy of non-surgical larynx-preservation comprehensive treatment in advanced laryngeal carcinoma

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Chinese Medical Journal 2020年第5期133卷 615-617页

作者： Nan-Xiang Chen Wen-Jun Fan Lin Ma Jia-Ling Wang Wen-Ming Wu Xin-Xin Zhang Department of Otolaryngology Head and Neck SurgeryInstitute of OtolaryngologyChinese People’s Liberation Army General HospitalNational Clinical Research Center for Otolaryngologic DiseasesKey Lab of Hearing Impairment Science of Ministry of EducationKey Lab of Hearing Impairment Prevention and Treatment of BeijingBeijing 100853China Department of Radiation Oncology Chinese People’s Liberation Army General HospitalBeijing 100853China

In China,patients with advanced laryngeal cancer are treated either with radical surgery followed by adjuvant radiotherapy or with non-surgical comprehensive treatment for organ *** important clinical trials have confirmed the possibility of laryngeal organ preservation in the treatment of advanced laryngeal cancer,[1,2]the best larynx-preservation strategy continues to be debated.[3,4]Here,we evaluated the efficacy of non-surgical comprehensive treatment that sought to preserve laryngeal function for patients with advanced laryngeal carcinoma.

关键词： laryngeal surgical treatment

Novel technique for lymphadenectomy along left recurrent laryngeal nerve during thoracoscopic esophagectomy

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World Journal of Gastroenterology 2020年第12期26卷 1340-1351页

作者： Wen-Shu Chen Li-Huan Zhu Wu-Jin Li Peng-Jie Tu Jian-Yuan Huang Pei-Lin You Xiao-Jie Pan Department of Thoracic Surgery Shengli Clinical Medical College of Fujian Medical UniversityFujian Provincial HospitalFuzhou 350001Fujian ProvinceChina

BACKGROUND In esophageal squamous carcinoma,lymphadenectomy along the left recurrent laryngeal nerve(RLN)is recommended owing to its highly metastatic ***,this procedure is difficult due to limited working space in the left upper mediastinum,and increases postoperative *** To present a novel method for lymphadenectomy along the left RLN during thoracoscopic esophagectomy in the semi-prone *** The fundamental concept of this novel method is to exfoliate a bilateral pedicled nerve flap,which is a two-dimensional membrane,which includes the left RLN,lymph nodes(LNs)along the left RLN,and tracheoesophageal vessels,by suspending the esophagus to the dorsal side and pushing the trachea to the ventral side(named“bilateral exposure method”).Then,the hollow-out method is performed to transform the two-dimensional membrane to a three-dimensional structure,in which the left RLN and tracheoesophageal vessels are easily distinguished and preserved during lymphadenectomy along the left *** novel method was retrospectively evaluated in 116 consecutive patients with esophageal squamous carcinoma from August 2016 to February *** There were 58 patients in each *** significant difference was found between the two groups in terms of age,gender,postoperative pneumonia,anastomotic fistula,and postoperative ***,the number of dissected LNs along the left RLN in this novel method was significantly higher than that in the conventional method(4.17±0.359 vs 2.93±0.463,P=0.0447).Moreover,the operative time and the rate of postoperative hoarseness in the novel method were significantly lower than those in the conventional method(306.0±6.774 vs 335.2±7.750,P=0.0054;4/58 vs 12/58,P=0.0312).CONCLUSION This novel method for lymphadenectomy along the left RLN during thoracoscopic esophagectomy in the semi-prone position is much safer and more effective.

关键词： Bilateral pedicled nerve flap Bilateral exposure method Hollow-out method Left recurrent laryngeal nerve Lymphadenectomy Thoracoscopic esophagectomy

Incidence and mortality of laryngeal cancer in China, 2015

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Chinese Journal of Cancer Research 2020年第1期32卷 10-17页

作者： Yutong He Di Liang Daojuan Li Baoen Shan Rongshou Zheng Siwei Zhang Wenqiang Wei Jie He Cancer Institute the Fourth Hospital of Hebei Medical University/the Tumor Hospital of Hebei ProvinceShijiazhuang 050011China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100021China

Objective: Using data from cancer registries to estimate laryngeal cancer incidence and mortality in China, ***: Data submitted from 501 cancer registries were checked and evaluated according to the criteria of data quality control and 368 registries’ data were qualified for the final analysis. Data were stratified by area(urban/rural), sex, age group and combined with national population data to estimate laryngeal cancer incidence and mortality in China, 2015. China population census in 2000 and Segi’s population were used for ***: The percentage of cases morphological verified(MV%) of laryngeal cancer was 74.18%. The percentage of death certificate-only cases(DCO%) was 2.10%. And the mortality to incidence(M/I) ratio was *** 25,300 new cases of laryngeal cancer were diagnosed in 2015 and 13,700 deaths were reported. The crude rate of laryngeal cancer was 1.84 per 100,000(males and females were 3.20 and 0.42 per 100,000, respectively).Age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 1.18 and 1.19 per 100,000, respectively. The cumulative incidence rate(0-74 years old) was 0.15%.The crude mortality rate was 1.00 per 100,000. Age-standardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were 0.61 and 0.61 per 100,000, respectively, with the cumulative rate(0-74 years old) was 0.07%. Incidence and mortality of laryngeal cancer in males were higher than those in females. And the rates in urban areas were higher than those in rural ***: The incidence and mortality of laryngeal cancer in China were low. And the rates were significantly higher in males than in females. Risk factor control and targeted prevention should be strengthened.

关键词： China laryngeal cancer incidence mortality

Correlation of survivin,p53 and Ki-67 in laryngeal cancer Hep-2 cell proliferation and invasion

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Asian Pacific Journal of Tropical Medicine 2015年第8期8卷 626-631页

作者： Shi-Geng Pei Ju-Xiang Wang Xue-Ling Wang Qing-Jun Zhang Hong Zhang Department of Otolaryngology Head and Neck Surgery Affiliated Hospital of Hebei Engineering University Hebei Engineering University Medical College

Objective: To investigate the mechanism of survivin, p53 and Ki-67 on Hep-2 human laryngeal cancer endothelial cell proliferation and invasion. Methods: laryngeal squamous cell carcinoma and paracancerous normal tissues were collected, total RNA was extracted from tissues, survivin, p53 and Ki-67 gene m RNA expression levels in laryngeal cancer and the adjacent tissues were detected by Real-time PCR. Human laryngeal cancer Hep-2 epithelial cells were selected, survivin gene was overexpressed, and cell proliferation was detected by MTT. p53 and Ki-67 gene expression changes in overexpressed survivin gene were detected by Western blot. Changes in Hep-2 cell invasive ability were studied when survivin was overexpressed as detected by Transwell invasion assay. Results: In the adjacent tissues, survivin, p53 and Ki-67 gene relative expression levels were 1.72 ± 0.9, 13.7 ± 5.7 and 5.7 ± 1.3, respectively; while in cancer tissues, gene relative expression levels were 53.7 ± 8.3, 66.7 ± 5.2 and 61.0 ± 3.1, respectively, which was significantly increased. As detected by MTT, relative cell survival rate within 12 h of survivin overexpression were: load control group,(88.5±1.6)%; overexpressed group,(90.3±1.9)%. Transwell invasion assay results indicated that overexpressed survivin could significantly increase the relative survival rate of cells. Conclusions: Expressions of p53, Ki67 and survivin are increased in cancer; and there is a positive correlation between survivin, p53 and Ki67 expressions in laryngeal carcinoma.

关键词： Survivin p53 Ki67 Hep-2 Transwell laryngeal cancer

Inhibitive effect of IL-24 gene on CD133^+ laryngeal cancer cells

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Asian Pacific Journal of Tropical Medicine 2014年第11期7卷 867-872页

作者： Jin-Zhang Cheng Dan Yu Hui Zhang Chun-Shun Jin Yan Liu Xue Zhao Xin-Meng Qi Xueshi-Bojie Liu Second Affiliated Hospital of Jilin University

Objective:To explore the inhihitive and apoptosis inductive effect of IL-24 genes on CD133^+laryngeal cancer cells in Hep-2 ***:Human peripheral blood monocytes were *** total RNA was extracted by using Trizol method and reverse transcripted into cDNA using RT-PCR *** P1 and P2 was designed for the amplification of human IL-24 *** confirmation of agarose gel electrophoresis tests,TA was cloned into pMD19-T simple *** Ⅰ and Xho Ⅰ double digesting human IL-24 and pIRES2-ZsGreen1 and eukaryotic expression vector were used to establish the pIRES2-ZsGreen1-hIL-24 vector,and detected by enzyme digestion and gene sequencing *** cytometry(FCM) was used to isolate CD133^+ cells from Hep-2 ***133^+ cells were transfected with pIRES2-ZsGreen1-hIL-24 through liposome *** detection,MTT and FCM were used to observe the effect of IL-24 gene on CD133^+ laryngeal cancer Hep-2 ***:Lipotin mediated transfection of recombinant pIRES2-ZsGreen1-hIL-24 plasmid into CD133^+ Hep-2 could expressed IL-24 gene in cells *** results showed that IL-24 transfected group was significantly suppressed compared to empty vector group and control group(Plaryngeal cells in Hep-2 line and promote their apoptosis.

关键词： IL-24 CD133 laryngeal cancer Cancer stem cells Gene therapy

Schwannoma originating from the recurrent laryngeal nerve in a thyroid cancer patient: A case report and review of the literature

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World Journal of Clinical Cases 2018年第16期6卷 1202-1205页

作者： Xie-Qun Xu Tao Hong Chao-Ji Zheng Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

BACKGROUND Schwannoma rarely originates from the recurrent laryngeal nerve, and there are few reports on schwannoma originating from the recurrent nerve in the mediastinum. Herein, we present an extremely rare case of schwannoma originating from the recurrent laryngeal nerve in the *** SUMMARY This is a case report of one patient diagnosed with thyroid cancer with schwannoma originating from the recurrent laryngeal nerve in the neck, which was incidentally found during a thyroidectomy, and a review of the *** Preoperative diagnostic examinations are of less use for detecting schwannoma originating from a recurrent laryngeal nerve in the neck in such small size, which may only incidentally be found during a thyroidectomy. Surgical excision with opening the capsule and shelling out the tumor is the treatment of choice. If the nerve is unable to be preserved, end-to-end recurrent laryngeal nerve anastomosis may be a simple and minimally invasive reconstruction procedure to improve phonation.

关键词： Schwannoma Recurrent laryngeal nerve Thyroid cancer Head and neck Surgery Case report

Effect and mechanism of miR-34a on proliferation, apoptosis and invasion of laryngeal carcinoma cells

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Asian Pacific Journal of Tropical Medicine 2016年第5期9卷 480-484页

作者： Ju-Xiang Wang Qing-Jun Zhang Shi-Geng Pei Bao-Liang Yang Affiliated Hospital of Hebei University of Engineering

Objective: To discuss the effect and mechanism of miR-34 a on the proliferation, apoptosis and invasion of laryngeal carcinoma cells. Methods: The laryngeal squamous carcinoma Hep2 cells were transiently transfected with miR-34 a mimics and miR-34 a NC. The MTT, colony-forming assay, Hoechst staining and Annexin V-PI double staining flow cytometry were employed to detect the effect of miR-34 a on the viability and apoptosis of laryngeal squamous carcinoma Hep2 cells; Transwell assay to defect the effect of miR-34 a on the migration and invasion of laryngeal squamous carcinoma Hep2 cells; western blot and RTPCR assay to defect the effect of miR-34 a mimics on the expression of survivin and Ki-67 m RNA in laryngeal squamous carcinoma Hep2 cells. Results: Compared with miR-34 a NC group, the cell viability in miR-34 mimics group was significantly decreased(Plaryngeal carcinoma cells and inhibit the cell proliferation and invasion, which is related to the down-regulated expression of survivin and Ki-67.

关键词： Mi R-34a laryngeal squamous carcinoma Hep2 cells Proliferation Apoptosis Invasion

A CASE-CONTROL STUDY OF THE ETIOLOGY OF laryngeal CANCER IN LIAONING PROVINCE

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Chinese Medical Journal 1995年第5期 29-32页

作者：郭星程美华费声重 DepartmentofOtorhenolaryngology ChinaMedicalUniversity DepartmentofENT CentralHospital

A case-control study of laryngeal cancer was conducted in Liaoning Province between January 1991 and April 1992 among 100 subjects with newly diagnosed cancer and 100 controls. The results of one factor analysis, odd ratio (OR), and conditional logistic regression indicated that smoking was the first significant risk factor for laryngeal cancer with an OR value of 16.8. Tobacco smoking ranked the first with an OR value of 30.4. Other factors such as alcoholic indulgence, insufficient intake of vegetable and fruits in winter and spring, air pollution in room and working environment, and fatigue of vocal cords were closely associated with the occurrence of laryngeal cancer.

关键词： laryngeal smoking alcoholic intake vocal Liaoning winter vegetable fruits cords