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Pure large cell neuroendocrine carcinoma originating from the endometrium: A case report

World Journal of Clinical Cases 2021年第14期9卷 3449-3457页

作者： Ran Du Feng Jiang Zheng-Yan Wang Yan-Qing Kang Xiu-Yu Wang Ying Du Department of Pathology Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina Department of Thoracic Surgery Liaocheng Tumor HospitalLiaocheng 252000Shandong ProvinceChina Department of Radiology Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina

BACKGROUND large cell neuroendocrine carcinoma(LCNEC)of the endometrium is an uncommon and highly aggressive tumor that has not been comprehensively *** report a case of pure endometrial LCNEC and review the current literature of similar cases to raise awareness of the histological features,treatment,and prognosis of this *** SUMMARY We report the case of a 73-year-old woman who presented with irregular postmenopausal vaginal *** showed an enlarged uterus and a 5.1 cm×3.3 cm area of medium and low echogenicity in the uterine *** by dilatation and curettage suggested poorly differentiated *** resonance imaging revealed a heterogeneously enhanced uterine tumor with diffuse infiltration of the posterior wall of the uterine myometrium and enlarged pelvic lymph *** patient underwent a hysterectomy and bilateral adnexal *** observation revealed an ill-defined white solid mass of the posterior wall of the uterus infiltrating into the serosa with multiple solid nodules on the serous ***,the tumor cells showed neuroendocrine morphology(organoid nesting).Immunohistochemistry revealed the tumor cells were diffusely positive for the neuroendocrine markers CD56,chromogranin A,and ***,the tumor was diagnosed as stage IIIC endometrial *** Pathologic findings and immunohistochemistry are essential in making a diagnosis of endometrial LCNEC.

关键词： Neuroendocrine carcinoma large cell large cell neuroendocrine carcinoma Endometrial Therapy Prognosis Case report

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Prognostic value of interim ^(18)F-FDG PET/CT in diffuse large B-cell lymphoma

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Chinese Journal of Cancer Research 2013年第1期25卷 95-101页

作者： Zhitao Ying Xuejuan Wang Yuqin Song Wen Zheng Xiaopei Wang Yan Xie Ningjing Lin Meifeng Tu Lingyan Ping Weiping Liu Lijuan Deng Chen Zhang Zhi Yang Jun Zhu Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of LymphomaPeking University Cancer Hospital & Institute Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Nuclear MedicinePeking University Cancer Hospital & Institute

Objective： Diffuse large B-cell lymphoma （DLBCL） is a heterogeneous disease. The prognostic factor currently used is not accurate enough to predict the outcomes of patients with DLBCL. The prognostic significance of interim PET/CT in DLBCL remains controversial. The aim of this study is to determine the predictive value of interim 18F-FDG PET/CT after first-line treatment in patients with DLBCL. Methods： Thirty-two patients with DLBCL underwent baseline, interim and post-treatment lSF-FDG PET/CT scans. Imaging results were analyzed for the survival of patients via software SPSS 13.0, retrospectively. Results： Thirty-one of the 32 patients were treated with R-CHOP regimen, and interim 18F-FDG PET/CT of 24 patients was performed after 2 cycles of treatment. After a median follow-up period of 16.7 months, the 2-year progression-free survival （PFS） rates were significantly different between the groups above and below SUVmax CUt-Off value of 2.5 （P=0.039）. No significant differences were found in the 2-year PFS rates if SUVm, cut-offvalues were set as 2.0 and 3.0, respectively （P=0.360; P=0.113）. Conclusions： Interim PET/CT could predict the prognosis of DLBCL patients with the SUVmax cut-off value of 2.5, but more clinical data should be concluded to confirm this conclusion.

关键词： Fludeoxy-glucose F18 lyrnphoma large cell diffuse prognosis standard utility value

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