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language Disorders in Alzheimer’s Disease and Phatic function

Open Journal of Psychiatry 2016年第3期6卷 213-217页

作者： Philippe Thomas Cyril Hazif-Thomas Centre de Recherches Sémiotiques (CeReS EA 3648) Université de Limoges Limoges France Department of Psychiatry for the Elderly (EA 4686) Brest France

Alzheimer’s disease is accompanied by progressive aphasia which intensifies the cognitive problems. The quality of the care given to the patient influences, however, the evolution of his language difficulties. The way the vulnerable person is aided, and the extent to which his efforts to make himself understood by his human environment are validated, contribute to preventing the development of a feeling of failure, a tendency to give up, and retrogressive tendencies. Repetition of interpersonal disqualifiers, care dispensed neglecting inter subjectivity, to the contrary encourages the patient to limit contact with his environment and so precipitate his language difficulties. Aphasia is thus linked to the insufficiency of human communication. The consequences of this disorder can be limited by taking into account the phatic language function to keep communication channels open. The human relationship is an encounter, an act of mutual identity-giving. Alzheimer-patient identity break-down is linked to cognitive troubles and to the failure of patients’ relationship attempts.

关键词： Alzheimer Disease Aphasia Semiotics language function

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Intra-operative mapping and language protection in glioma

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Chinese Medical Journal 2021年第20期134卷 2398-2402页

作者： Shi-Meng Weng Sheng-Yu Fang Lian-Wang Li Xing Fan Yin-Yan Wang Tao Jiang Beijing Neurosurgical Institute Capital Medical UniversityBeijing 100070China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Research Unit of Accurate Diagnosis Treatmentand Translational Medicine of Brain TumorsChinese Academy of Medical SciencesBeijing 100070China

The demand for acquiring different languages has increased with increasing globalization.However,knowledge of the modification of the new language in the neural language network remains insufficient.Although many details of language function have been detected based on the awake intra-operative mapping results,the language neural network of the bilingual or multilingual remains unclear,which raises difficulties in clinical practice to preserve patients’full language ability in neurosurgery.In this review,we present a summary of the current findings regarding the structure of the language network and its evolution as the number of acquired languages increased in glioma patients.We then discuss a new insight into the awake intra-operative mapping protocol to reduce surgical risks during the preservation of language function in multilingual patients with glioma.

关键词： Glioma Intra-operative mapping language function language protection

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Identification of risk factors for poor language outcome in surgical resection of glioma involving the arcuate fasciculus:an observational study

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Neural Regeneration Research 2021年第2期16卷 333-337页

作者： Fang-Ye Li Hong-Yu Liu Jun Zhang Zheng-Hui Sun Jia-Shu Zhang Guo-Chen Sun Xin-Guang Yu Xiao-Lei Chen Bai-Nan Xu Department of Neurosurgery First Medical Center of Chinese PLA General HospitalBeijingChina Department of Neurosurgery Hainan Hospital of Chinese

The arcuate fasciculus is a critical component of the neural substrate of human language function.Surgical resection of glioma adjacent to the arcuate fasciculus likely damages this region.In this study,we evaluated the outcome of surgical resection of glioma adjacent to the arcuate fasciculus under the guidance of magnetic resonance imaging and diffusion tensor imaging,and we aimed to identify the risk factors for postoperative linguistic deficit.In total,54 patients with primary glioma adjacent to the arcuate fasciculus were included in this observational study.These patients comprised 38 men and 16 women(aged 43±11 years).All patients underwent surgical resenction of glioma under the guidance of magnetic resonance imaging and diffusion tensor imaging.Intraoperative images were updated when necessary for further resection.The gross total resection rate of the 54 patients increased from 38.9%to 70.4%by intraoperative magnetic resonance imaging.Preoperative language function and glioma-to-arcuate fasciculus distance were associated with poor language outcome.Multivariable logistic regression analyses showed that glioma-to-arcuate fasciculus distance was the major independent risk factor for poor outcome.The cutoff point of glioma-to-arcuate fasciculus distance for poor outcome was 3.2 mm.These findings suggest that intraoperative magnetic resonance imaging combined with diffusion tensor imaging of the arcuate fasciculus can help optimize tumor resection and result in the least damage to the arcuate fasciculus.Notably,glioma-to-arcuate fasciculus distance is a key independent risk factor for poor postoperative language outcome.This study was approved by the Ethics Committee of the Chinese PLA General Hospital,China(approval No.S2014-096-01)on October 11,2014.

关键词： arcuate fasciculus central nervous system brain diffusion tensor imaging intraoperative magnetic resonance imaging language function risk factor trial

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Systemic functional Linguistics' Influence on the Communicative Approach

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神州 2014年第11期 59-59页

作者：陈莹武警警官学院外语第一教研室

As the founder of systemic functional linguistics,Halliday once said the driving force of producing his linguistictheories is of education.Therefore,his theories have a great influ-ence on foreign language teaching and inspire the creation ofsome new teaching theories and methods.And this paper focuseson the influence produced by systemic functional linguistics up-on the communicative approach.

关键词： systemic functional linguistics communicativeapproach situation language function language system

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