Identification of risk factors for poor language outcome in surgical resection of glioma involving the arcuate fasciculus:an observational study

作     者：Fang-Ye Li Hong-Yu Liu Jun Zhang Zheng-Hui Sun Jia-Shu Zhang Guo-Chen Sun Xin-Guang Yu Xiao-Lei Chen Bai-Nan Xu Fang-Ye Li;Hong-Yu Liu;Jun Zhang;Zheng-Hui Sun;Jia-Shu Zhang;Guo-Chen Sun;Xin-Guang Yu;Xiao-Lei Chen;Bai-Nan Xu

作者机构：Department of NeurosurgeryFirst Medical Center of Chinese PLA General HospitalBeijingChina Department of NeurosurgeryHainan Hospital of Chinese 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第2期

页      面：333-337页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Clinical Research Fostering Fund of Chinese PLA General Hospital in China,No.2017FC-TSYS-2012(to FYL) Youth Program of the Natural Science Foundation of Hainan Province of China,No.819QN378(to FYL) the National Natural Science Foundation of China,No.81771481(to XLC) China National Key R&D Program,No.2018YFC1312602(to XLC) National Clinical Research Center for Geriatric Diseases of China,No.NCRCGPLAGH-2017007(to XLC) 

主　　题：arcuate fasciculus central nervous system brain diffusion tensor imaging intraoperative magnetic resonance imaging language function risk factor trial 

摘      要：The arcuate fasciculus is a critical component of the neural substrate of human language *** resection of glioma adjacent to the arcuate fasciculus likely damages this *** this study,we evaluated the outcome of surgical resection of glioma adjacent to the arcuate fasciculus under the guidance of magnetic resonance imaging and diffusion tensor imaging,and we aimed to identify the risk factors for postoperative linguistic *** total,54 patients with primary glioma adjacent to the arcuate fasciculus were included in this observational *** patients comprised 38 men and 16 women(aged 43±11 years).All patients underwent surgical resenction of glioma under the guidance of magnetic resonance imaging and diffusion tensor *** images were updated when necessary for further *** gross total resection rate of the 54 patients increased from 38.9%to 70.4%by intraoperative magnetic resonance *** language function and glioma-to-arcuate fasciculus distance were associated with poor language *** logistic regression analyses showed that glioma-to-arcuate fasciculus distance was the major independent risk factor for poor *** cutoff point of glioma-to-arcuate fasciculus distance for poor outcome was 3.2 *** findings suggest that intraoperative magnetic resonance imaging combined with diffusion tensor imaging of the arcuate fasciculus can help optimize tumor resection and result in the least damage to the arcuate ***,glioma-to-arcuate fasciculus distance is a key independent risk factor for poor postoperative language *** study was approved by the Ethics Committee of the Chinese PLA General Hospital,China(approval No.S2014-096-01)on October 11,2014.