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Efficacy of incremental loads of cow's milk as a treatment for lactose malabsorption in Japan

World Journal of Clinical Cases 2023年第4期11卷 797-808页

作者： Matsuri Hasegawa Kazuko Okada Satoru Nagata Shigetaka Sugihara Department of Pediatrics Tokyo Women's Medical University Medical Center EastDepartment of PediatricsTokyo Women’s Medical University Medical Center EastArakawa-ku 116-8561TokyoJapan Department of Pediatrics Okada Pediatric ClinicShinjuku-ku 169-0072TokyoJapan Department of Pediatrics Tokyo Women’s Medical UniversityShinjuku-ku 162-8666TokyoJapan

BACKGROUND lactose intolerance(LI)is commonly seen in East Asian *** studies showed that lactose or milk loading has been used as a treatment for lactose malabsorption(LM)in Western countries,but there have been no reports regarding this type of treatment in *** lactose or milk loading requires ingestion of large amounts of lactose within a short period,this is considered to be too harsh for Japanese people because of their less habitual milk consumption(175 mL per day in average)than Western *** this study,we demonstrated lactose tolerance acquisition in a suitable way for *** To examine the efficacy of lactose(cow’s milk)loading treatment in patients with *** Individuals with abdominal symptoms induced by milk or dairy products(LI symptoms)were identified with a questionnaire.A 20 g lactose hydrogen breath test(LHBT)was carried out to confirm LM diagnosis and to evaluate co-existence of small intestinal bacterial overgrowth(SIBO).Respondents diagnosed with LM were selected as study subjects and were treated with incremental loads of cow’s milk,starting from 30 mL and increasing up to 200 mL at 4-7 d *** the treatment,changes in symptoms and LM diagnostic value of 20 g LHBT were *** samples pre-and post-treatment were examined for changes in intestinal microbiota using 16S rRNA *** consent was obtained prior to each stage of the *** In 46 subjects with LI symptoms(10-68 years old,mean age 34 years old)identified with the questionnaire,35(76.1%)were diagnosed with LM by 20 g LHBT,and 6 had co-existing *** treatment with incremental cow’s milk was carried out in 32 subjects diagnosed with LM(14-68 years old,median age 38.5 years old).The mean period of the treatment was 41±8.6 *** of symptoms was observed in 29(90.6%;95%confidence interval:75.0%-98.0%)*** 20 g LHBT indicated that 10(34.5%)subjects had improved diagnostic value of LM,no change was

关键词： lactose Intolerance lactose malabsorption lactose loading treatment Intestinal bacterial flora Fecal microbiota

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Hydrogen breath test for the diagnosis of lactose intolerance,is the routine sugar load the best one?

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World Journal of Gastroenterology 2008年第40期14卷 6204-6207页

作者： Fiorenza Argnani Mauro Di Camillo Vanessa Marinaro Tiziana Foglietta Veronica Avallone Carlo Cannella Piero Vernia Gastroenterologia A e Scienza dell'Alimentazione Sapienza Università di Roma

AIM: To evaluate the prevalence of lactose intolerance (LI) following a load of 12.5 g in patients diagnosed as high-grade malabsorbers using the hydrogen breath test (HBT)-***: Ninety patients showing high-grade malabsorption at HBT-25 were submitted to a second HBT with a lactose load of 12.5 *** hydrogen production,area under the curve of hydrogen excretion and occurrence of symptoms were ***: Only 16 patients (17.77%) with positive HBT-25 proved positive at *** production was lower as compared to HBT-25 (peak value 21.55 parts per million (ppm) ± 29.54 SD vs 99.43 ppm ± 40.01 SD; P lactose and a strict lactose restriction on the basis of a "standard" HBT is,in most instances,***,the 25 g lactose tolerance test should probably be substituted by the 12.5 g test in the diagnosis of LI,and in providing dietary guidelines to patients with suspected lactose malabsorption/intolerance.

关键词： Lactase deficiency lactose malabsorption lactose intolerance Hydrogen breath test

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Molecularly defined adult-type hypolactasia among working age people with reference to milk consumption and gastrointestinal symptoms

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World Journal of Gastroenterology 2007年第8期13卷 1230-1235页

作者： Sari R Anthoni Heli A Rasinper Antti J Kotamies Hanna A Komu Harri K Pihlajamki Kaija-Leena Kolho Irma E Jrvel Hospital for Children and Adolescents University of Helsinki Finland Department of Medical Genetics University of Helsinki Finland Helsinki Centre of Economic Research Helsinki Finland Central Military Hospital Helsinki Finland Helsinki University Central Hospital Laboratory of Molecular Genetics Helsinki Finland

AIM: To study milk consumption and subjective milk- related symptoms in adults genotyped for adult-type hypolactasia. METHODS: A total of 1900 Finnish adults were genotyped for the C/T-13910 variant of adult-type hypolactasia and filled in a structured questionnaire concerning milk consumption and gastrointestinal problems. RESULTS: The C/C-13910 genotype of adult-type hypolactasia was present in 18% of the study population. The prevalence of the C/C-13910 genotype was higher among subjects who were undergoing investigations because of abdominal symptoms (24%, P < 0.05). Those with the C/C-13910 genotype drank less milk than subjects with either the C/T-13910 or the T/T-13910 genotype of lactase persistence (18% vs 38%; 18% vs 36%, P < 0.01). Subjects with the C/C-13910 genotype had experienced more gastrointestinal symptoms (84%) during the preceding three-month period than those with the C/T-13910 (79%, P < 0.05) or the T/T-13910 genotype (78 %, P < 0.05). Only 9% (29/338) of the subjects with the C/C-13910 genotype consumed milk and reported no symptoms from ***: Gastrointestinal symptoms are more common among adults with the C/C-13910 genotype of adult-type hypolactasia than in those with genotypes of lactase persistence.

关键词： Lactase persistence lactose malabsorption C/T-13910 genotype Abdominal symptoms Milk consumption

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Prevalence of lactase persistent/non-persistent genotypes and milk consumption in a young population in north-west Russia

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World Journal of Gastroenterology 2009年第15期15卷 1849-1853页

作者： Yulia Khabarova Suvi Torniainen Hanna Nurmi Irma Jrvel Mauri Isokoski Kari Mattila Department of Family Medicine Northern State Medical University Department of Medical Genetics University of Helsinki Tampere School of Public Health University of Tampere Medical School University of Tampere33014 and Centre of General PracticeHealth District of Pirkanmaa

AIM： TO estimate the prevalence of the lactase non-persistent genotype （C/C-23910） in a northern Russian population in accordance with ethnicity, and to evaluate self-reported milk consumption depending on lactase activity. METHODS： Blood samples for genotyping lactase activity, defining the C/T-13910 variant by polymerase chain reaction, and direct sequencing were taken from 231 medical students of Russian origin aged 17-26 years. We analyzed milk product consumption by questionnaire which was specially designed for the estimation of milk consumption and abdominal complaints. RESULTS： We found that the prevalence of the C/C-13190 genotype in the northern Russian population was 35.6%. The other genotypes nearby C/T-13910 and associated with lactase activity were not present in the study population. The consumption of milk among people with the non-persistent genotype tended to be lower than among the lactose tolerant subjects, but was not statistically significant. CONCLUSION： An investigation of the lactase persistent genotype in a northern Russian population has not been performed before, The genotype did not affect the consumption of milk products in this population which could be explained by low consumption of milk products among the entire study population.

关键词： C/C-13910 genotype Hypolactasia Lactasepersistence/non-persistence lactose malabsorption Milk consumption North-west Russia

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