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A Smart Procedure for the Femtosecond Laser-Based Fabrication of a Polymeric lab-on-a-chip for Capturing Tumor Cell

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Engineering 2021年第10期7卷 1434-1440页

作者： Annalisa Volpe Udith Krishnan Maria Serena Chiriacò Elisabetta Primiceri Antonio Ancona Francesco Ferrara Department of Physics University of Bari“Aldo Moro”Bari 70126Italy Institute for Photonics and Nanotechnologies Bari 70126Italy Institute of Nanotechnology Lecce 73100Italy STMicroelectronics Lecce 73100Italy

Rapid prototyping methods for the design and fabrication of polymeric labs-on-a-chip are on the rise,as they allow high degrees of precision and *** example,a microfluidic platform may require an optimization phase in which it could be necessary to continuously modify the architecture and geometry;however,this is only possible if easy,controllable fabrication methods and low-cost materials are *** this paper,we describe the realization process of a microfluidic tool,from the computer-aided design(CAD)to the proof-of-concept application as a capture device for circulating tumor cells(CTCs).The entire platform was realized in polymethyl methacrylate(PMMA),combining femtosecond(fs)laser and micromilling fabrication *** multilayer device was assembled through a facile and low-cost solvent-assisted method.A serpentine microchannel was then directly biofunctionalized by immobilizing capture probes able to distinguish cancer from non-cancer cells without *** low material costs,customizable methods,and biological application of the realized platform make it a suitable model for industrial exploitation and applications at the point of care.

关键词： lab-on-a-chip Fs laser Circulating tumor cells Point of care Thermal bonding Polymers

DNA computing model based on lab-on-a-chip and its application on solving the timetabling problem

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Progress in Natural Science:Materials International 2008年第5期18卷 633-637页

作者： Fengyue Zhang a,1, Bo Liu b,1, Wenbin Liu c, Qiang Zhang d a Department of Biomedical Engineering, School of Life Science and Technology, Beijing Institute of Technology, Beijing 100081, China b Chinese Academy of Inspection and Quarantine, Beijing 100029, China c College of Computer Science and Engineering, Wenzhou University, Wenzhou, Zhejiang 325027, China d Liaoning Key laboratory of Intelligent Information Processing, Dalian University, Dalian, Liangning 116622, China Department of Biomedical Engineering School of Life Science and Technology Beijing Institute of Technology Beijing 100081 China Chinese Academy of Inspection and Quarantine Beijing 100029 China College of Computer Science and Engineering Wenzhou University Wenzhou Zhejiang 325027 China Liaoning Key laboratory of Intelligent Information Processing Dalian University Dalian Liangning 116622 China

The essential characteristic of DNA computation is its massive parallelism in obtaining and managing information. With the develop- ment of molecular biology technique, the eld of DNA computation has made a great progress. By using an advanced biochip technique, laboratory-on-a-chip, a new DNA computing model is presented in the paper to solve a simple timetabling problem, which is a special ver- sion of the optimization problems. It also plays an important role in education and other industries. With a simulated biological experiment, the result suggested that DNA computation with lab-on-a-chip has the potential to solve a real complex timetabling problem.

关键词： DNA computing Timetabling problem lab-on-a-chip

Optical Properties of Tetrahedral Amorphous Carbon Films and Their Potential for lab-on-a-chip

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Materials Sciences and Applications 2015年第5期6卷 445-455页

作者： Katja Guenther Frank Sonntag Teja Roch Andrés Fabián Lasagni University of Applied Sciences Mittweida Mittweida Germany Fraunhofer Institute for Material and Beam Technology IWS Dresden Germany TU Dresden Institute of Manufacturing Technology Dresden Germany

In this study, tetrahedral amorphous carbon (ta-C) films with thicknesses between several 100 nm and several micrometers have been deposited onto polished tungsten carbide and steel substrates by pulsed laser deposition (PLD) using an excimer laser (248 nm wavelength). We investigate the optical properties (e.g. the refractive index (n) and extinction coefficient (k) in the visible and near-infrared wavelength range) of these layers in dependence of the used laser ablation fluence on the target. It is shown that n of ~2000 nm thick ta-C films can be tuned, depending on the sp3-content, between n = 2.5 and 2.8 at a wavelength of 632 nm. Besides of this k reduces with the sp3-content and is as low as 0.03 at sp3-contents of more than 75%. We proof that this gives the opportunity to prepare coating with tailored optical properties. Furthermore, it is shown that the ta-C films have low background fluorescence in the wavelengths range of 380 - 750 nm, which make this thin films attractive for certain optical, medical and biotechnological applications. We present for the first time that one possible application is the use in lab-on-a-chip-systems (LOC). Within these systems, the ultrasensitive detection of fluorescence markers and dyes is a challenge. In order to increase the signal-to-noise-ratio, a setup was developed, that used the specific optical properties of ta-C films produced by PLD. We used the ta-C film as an integrated reflector that combined low background fluorescence, a low reflectivity at the excitation wavelength and the high reflectivity at the emission wavelength. We prove that this setup improves the detection of fluorescence photons.

关键词： Tetrahedral Amorphous Carbon Pulsed Laser Deposition Thin Films Diamond-Like Carbon lab-on-a-chip

可分析DNA的片上“实验室”(lab-on-a-chip)

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电子产品世界 1999年第4期 34-34页

Biomimetic Infiltrating Surface Construction Based on Micro and Nano Structures

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Journal of Materials Science and Chemical Engineering 2024年第6期12卷 83-91页

作者： Zhicheng Zhou Jiayu Li Sisi Lu Quanying Lin Chien-Shiung Wu College Southeast University Nanjing China

Microfluidic chips hold significant potential for applications in various fields, such as biological analysis, chemical separation, and drug screening. Here, we draw inspiration from the natural ability of aquatic plants to capture different substances in streams, focusing on the design and fabrication of surfaces with micron and nano-scale structures to mimic the wetting phenomenon observed in nature, thereby achieving the capture and separation of specific substances. This paper reports on the self-assembly of magnetic nanoparticles, the preparation of flexible magnetic nano-chains, and the modification of microfluidic chip surfaces, providing a novel perspective and approach to microfluidic chip technology.

关键词： lab-on-a-chip Magnetic Nanoparticles Biosensors Microfluidic

Design of interdigitated transducers for acoustofluidic applications

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Nanotechnology and Precision Engineering 2022年第3期5卷 36-54页

作者： Shuren Song Qi Wang Jia Zhou Antoine Riaud State Key laboratory of ASIC and System School of MicroelectronicsFudan UniversityShanghaiPeople’s Republic of China

Interdigitated transducers(IDTs)were originally designed as delay lines for *** a century later,they have found new life as actuators for microfluidic *** generating strong acoustic fields,they trigger nonlinear effects that enable pumping and mixing of fluids,and moving particles without ***,the transition from signal processing to actuators comes with a range of challenges concerning power density and spatial resolution that have spurred exciting developments in solid-state acoustics and especially in IDT *** some familiarity with acoustofluidics,this paper aims to provide a tutorial for IDT design and characterization for the purpose of acoustofluidic *** is targeted at a diverse audience of researchers in various fields,including fluid mechanics,acoustics,and microelectronics.

关键词： Acoustic field Surface acoustic wave Transducer Finite-element analysis Simulation Acoustical properties lab-on-a-chip Acoustic wave attenuation

Application of microfluidic technologies on COVID-19 diagnosis and drug discovery

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药学学报:英文版 2023年第7期13卷 2877-2896页

作者： Zhun Lin Zhengyu Zou Zhe Pu Minhao Wu Yuanqing Zhang School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510080China

The ongoing coronavirus disease 2019(COVID-19) pandemic has boosted the development of antiviral *** technologies offer powerful platforms for diagnosis and drug discovery for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) diagnosis and drug *** this review,we introduce the structure of SARS-CoV-2 and the basic knowledge of microfluidic *** discuss the application of microfluidic devices in SARS-CoV-2 diagnosis based on detecting viral nucleic acid,antibodies,and *** highlight the contribution of lab-on-a-chip to manufacturing point-ofcare equipment of accurate,sensitive,low-cost,and user-friendly virus-detection *** then investigate the efforts in organ-on-a-chip and lipid nanoparticles(LNPs) synthesizing chips in antiviral drug screening and mRNA vaccine *** technologies contribute to the ongoing SARSCoV-2 research efforts and provide tools for future viral outbreaks.

关键词： Microfluidic COVID-19 SARS-CoV-2 lab-on-a-chip Detection Organ-on-a-chip Drug screen

Micro Flow-Through Thermocycler with Simple Meandering Channel with Symmetric Temperature Zones for Disposable PCR-Devices in Microscope Slide Format

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Journal of Bionic Engineering 2008年第4期5卷 291-298页

作者： Anett Reichert Jana Felbel Mark Kielpinski Matthias Urban Benno Steinbrecht Thomas Henkel Microfluidics Department Institute of Photonic Technology Arvato Digital Services Manufacturing EMEA

chip-based flow-through PCR implements the PCR as a continuous process for nucleic acid analytics. The sample is transported in a winding channel through temperature zones required for denaturation, annealing and extension. Main fields of application are the monitoring of continuous processes for rapid identification of contaminants and quality control as well as high throughput screening of cells or microorganisms. A modular arrangement with five heating zones for flow-through PCR is discussed and evaluated. The special heater arrangement allows the implementation of up to 40 cycles on the footprint of a microscope slide, which is placed on top ofa 5 zones heating plate. Liquid/liquid two phase flow of PCR reaction mixture and mineral oil have been applied to create a segmented flow process scheme. In that way, the developed system may provide flow-through PCR as a unit operation for the droplet based microfluidics platform. The single use of disposable devices is commonly preferred due to the sensitivity of the PCR process to contaminations. All-glass microfluidic chips and disposable chip devices, made from polycarbonate as a replication with identically geometry, have been fabricated and tested. For the first time, microchannel geometries with nearly circular profile developed by all-glass technology have been transferred to mass fabrication by injection compression molding. Both devices have been successfully applied for the detection of the tumor suppressor gene p53. Although product yield and selectivity of the amplification process do not depend on the chip material, a well defined, reliable segmented flow regime could only be realized in the all-glass chip.

关键词： lab-on-a-chip PCR microfluidics two-phase-flow injection molding point-of-care biomedical

An Optimised Surface Structure for Passive, Unidirectional Fluid Transport Bioinspired by True Bugs

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Journal of Bionic Engineering 2021年第2期18卷 375-386页

作者： Sebastian Lifka Florian Hischen Johannes Heitz Werner Baumgartner Institute of Biomedical Mechatronics Johannes Kepler University LinzAltenberger Straße 694040 LinzAustria Institute of Applied Physics Johannes Kepler University LinzAltenberger Straße 694040 LinzAustria

Some true bug species use droplet-shaped,open-capillary structures for passive,unidirectional fluid transport on their body surface in order to spread a defensive fluid to protect themselves against *** this paper we investigated if the shape of the structures found on bugs(bug-structure)could be optimised with regard to better performance in unidirectional fluid ***,to use this kind of surface structure in technical applications where fluid surface interaction occurs,it is necessary to adapt the structure geometry to the contact angle between fluid and *** on the principal of operation of the droplet-shaped structures,we optimised the structure shape for better performance in targeted fluid flow and increase in flexibility in design of the structure *** adapt the structure geometry and the structure spacing to the contact angle,we implemented an equilibrium simulation of the,the structure surrounding,*** order to verify the functionality of the optimised structure,we designed and manufactured a *** testing this prototype with pure water used as fluid,the functionality of the optimised structure and the simulation could be *** kind of structure may be used on technical surfaces where targeted fluid transport is needed,*** of condensate in order to prevent the surface from mold growth,microfluidics,lab-on-a-chip applications and on microneedles for efficient drug/vaccine coating.

关键词： biomimetics true bugs liquid-surface interaction passive unidirectional fluid transport microfluidics lab-on-a-chip