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Protective Effect and Mechanism of Kuntai Capsule on Angiotensin II-Induced Hypertension in Ovariectomized Rats

Chinese Journal of Integrative Medicine 2023年第6期29卷 526-533页

作者： GE Xiao-fen LI Sha-sha LIU Yan-hua LU Mei-qiu SU Hui-na YANG Xin SUN Xiao-wan Department of Obstetrics and Gynecology Peking University People's HospitalBeijing(100044)China Department of Obstetrics and Gynecology Dongying People's HospitalDongyingShandong Province(257000)China

Objective To explore the protective effect and mechanism of kuntai(KT)capsule on angiotensin II(Ang II)-induced hypertension in ovariectomized(OVX)rats.Methods Fifty-four rats were randomly divided into 6 groups according to a random number table,9 in each group:control,OVX sham+Ang II,OVX,OVX+Ang II,OVX+Ang II+E2,and OVX+Ang II+KT.OVX rats model was constructed by retroperitoneal bilateral ovariectomy.After 4 weeks of pretreatment with KT capsule[0.8 g/(kg·d)and 17-β-estradiol(E2,1.2 mg/(kg·d)]respectively,Ang II was injected into a micro-osmotic pump with a syringe to establish a hypertensive rat model.Blood pressure of rat tail artery was measured in a wake state of rats using a non-invasive sphygmomanometer.Blood pressure changes were compared between the intervention groups(OVX+Ang II+KT,OVX+Ang II+E2)and the negative control group(OVX+Ang II).Serum malondialdehyde(MDA)level and superoxide dismutase(SOD)activity were detected respectively.The expressions of oxidative stress-related protein superoxide dismutase2(SOD2)and anti-thioredoxin(TRX),autophagy marker protein[beclin1,light chain(LC)3 II/I ratio and autophagy canonical pathway protein phosphatidylinositol 3-kinase(PI3K)/serine/threonine kinase(AKT)-mammalian target of rapamycin(mTOR)]were evaluated by Western blotting.Results Compared with the OVX+Ang II group,the systolic blood pressure of OVX+Ang II+KT group was significantly lowered(P<0.05)but not the diastolic blood pressure.Besides,SOD2 and TRX protein levels in mycardial tissues were significantly reduced in the OVX+Ang II+KT group compared with the OVX+Ang II group(P<0.05).Oxidative stress serum markers MDA and SOD were down-and up-regulated in the OVX+Ang II+KT group,respectively(P<0.05).Compared with OVX+Ang II group,the levels of cardiac proteins beclin-1 and LC3II/LC3 I in OVX+Ang II+KT group were also up-regulated(P<0.05),and the expression levels of p-PI3K,p-AKT and mTOR protein were down-regulated(P<0.05).Conclusion KT could protect blood pressure of Ang II-induced OVX rats by inhibiting

关键词： Kuntai Capsule Chinese medicine perimenopausal hypertension angiotensin II

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Efficacy and Safety Investigation of Kuntai Capsule for the Add-back Therapy of Gonadotropin Releasing Hormone Agonist Administration to Endometriosis Patients： A Randomized,Double-blind, Blank-and Tibolone-controlled Study

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Chinese Medical Journal 2015年第4期128卷 427-432页

作者： Ji-Ming Chen Hong-Yan Gao Yi Ding Xia Yuan Qing Wang Qin Li Guo-Hua Jiang Department of Gynecology Third Affiliated Hospital of Soochow University Changzhou Jiangsu 213003 China Department of Gynecology Jintan Hospital Affiliated to Jiangsu University Jintan Jiangsu 213200 China

Background：As a Chinese Traditional Medicine product,Kuntai Capsule could improve the peri-menopausal symptoms in postmenopausal women.But it is still not clear whether Kuntai Capsule has a good effect on alleviating peri-menopausal symptoms induced by gonadotropin releasing hormone agonist （GnRH-a） treatment.The purpose of this study was to investigate the clinical effectiveness and safety of Kuntai Capsule,on peri-menopausal symptoms in endometriosis （EMS） patients,with postoperative GnRH-a treatment.Methods：Ninety EMS ovarian cyst women with postoperative GnRH-a administration were enrolled in the study,and were randomly divided into kuntai group,Tibolone group,or blank Control group.The therapeutic strategy in kuntai group was 4 Kuntai Capsules tid,po for 12 weeks after the first GnRH-a injection,while Tibolone 2.5 mg qd,po for 12 weeks in Tibolone group.There was no drug addition in Control group.Climacteric complaints were evaluated by Kupperman menopausal index （KMI） and hot flash/sweating score.Liver and renal functions,lipid profile,serum sex hormone levels and endometrial thickness were measured,and the frequency of adverse events in kuntai and Tibolone groups was recorded.Results：（l） Before GnRH-a therapy,the baseline parameter results were comparable in the three groups （P ＞ 0.05）.（2） After GnRH-a therapy,KMI and hot flash/sweating scores in all the three groups increased significantly （P ＜ 0.05）.At the 4th week after GnRH-a therapy,KMI and hot flash/sweating score results were as follows：Control group ＞ kuntai group ＞ Tibolone group （P ＜ 0.05）; at the 8th and 12th week after GnRH-a therapy,KMI and hot flash/sweating score in Control group were significantly higher than the other two groups （P ＜ 0.05）,and no significant difference was identified between kuntai and Tibolone group （P ＞ 0.05）.（3） No statistical change took place in the liver and renal functions and lipid profile in all the three groups after the treatment （P ＞ 0.05）.（4） The posttherapeutic serum follicle-stimulating hormone （FSH）,luteini

关键词： Endometriosis Kuntai Capsule Kupperman Menopausal Index Peri-menopausal Symptoms Tibolone

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Clinical observation of Kuntai Capsule combined with Fenmotong in treatment of decline of ovarian reserve function

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World Journal of Clinical Cases 2021年第28期9卷 8349-8357页

作者： Xin-Miao Lin Miao Chen Qiao-Ling Wang Xiao-Min Ye Hao-Fan Chen Department of Reproductive Health and Infertility Zhanjiang Central People’s HospitalZhanjiang 524037Guangdong ProvinceChina

BACKGROUND Decreased ovarian reserve function is an ovarian hypofunction disease that occurs in women before 40 years of age,leading to a decline in fertility and perimeno-pausal symptoms,such as irregular menstruation,amenorrhea,infertility,de-creased libido,and autonomic nervous dysfunction.Fenmatong(FMT)is a com-pound mixture of estradiol tablets and estradiol didroxyprogesterone tablets,which can improve ovarian reserve function by supplementation of exogenous estrogen.However,this treatment has also been shown to cause breast pain,gastrointestinal discomfort,irregular vaginal bleeding,and changes in sexual desire.In severe cases,FMT can promote the development of breast cancer,endometrial cancer,and venous embolic disease.AIM To observe the effects of Kuntai Capsules and FMT on endocrine indexes and uterine artery blood circulation in patients with decreased ovarian reserve func-tion.METHODS Patients(130)with decreased ovarian reserve function,who were treated in our hospital from May 2018 to May 2020,were divided into two groups:The FMT group,in which patients were treated with FMT,and the observation group,in which patients were treated with Kuntai Capsules.Chinese medicine symptom scores,uterine artery blood flow parameters,ovarian ultrasound test indexes,pictorial blood loss assessment chart(PBAC)scores,and hormone levels were recorded,and total effective rates were calculated for both groups.RESULTS The total effective rate in the observation group was higher than that in the FMT group(P<0.05).After treatment,primary symptoms,including low menstrual volume,delayed menstruation,red color and thick consistency of menses,di-zziness,palpitation,weakness at the waist and knee,insomnia and excessive dreaming,irritability,and dryness and astringency of the pudendal canal in the observation group decreased,and scores for primary and secondary symptoms in the observation group were significantly lower than those in the FMT group(P<0.05).The systolic peak flow rate(PSV),end-diastolic flow rate(EDV),ovarian diamet

关键词： Kuntai Capsule Fenmatong Ovarian reserve function decline Endocrine index Blood circulation

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Effects of Kuntai Capsule on follicular development and oocyte cohesin levels in aged mice

Effects of Kuntai Capsule on follicular development and oocy...

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第9届中国中西医结合学会妇产科专业委员会第二次学术会议

作者： Bin Zhang Nan Chu Xue-Min Qiu Wei Tang Hans-Jürgen Gober Da-Jin Li Ling Wang Obstetrics and Gynecology Hospital of Fudan University Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases The Academy of Integrative Medicine of Fudan University Hepato-Biliary-Pancreatic Surgery Division Department of Surgery Graduate School of Medicine the University of Tokyo Department of Pharmacy Kepler University Clinic Neuromed Campus Laboratory for Reproductive Immunology Hospital & Institute of Obstetrics and Gynecology IBS Fudan University Shanghai Medical College

Women with advanced maternal age experience more incidences of sterility, miscarriage and embryo aneuploidy. Recent studies have revealed that age-related aneuploidy is mainly caused by the reduction of cohesin complexesin oocyte. Kuntai Capsule is a kind of Traditional Chinese medicine that was firstly used to retrieve the menopausal syndrome. Several studies have indicated its effect to improve the ovarian reserve and oocyte quality in patients undergoing in vitro fertilization-embryo transfer. To evaluate whether Kuntai Capsule could affect cohesion levels and improve the ovarian function of aged mice, 9 month-old C57 BL/6 J mice were divided into different groups and treated with saline, 17β-estradiol, and different concentrations of Kuntai Capsule for 4 weeks. HE staining and anti-VASA staining were used to detect the amounts of follicles. The apoptosis of follicles was measured by anti-γH2 AX staining and TUNEL assay. The density of cohesin subunits-REC8, SMC1β and SMC3 in oocytes were evaluated by immunofluorescent staining. Our findings revealed that administration of Kuntai Capsule increases the total number as well as the number of primordial and primary follicles in a dose-dependent manner. Outcome fromanti-γH2 AX staining and TUNEL assay demonstrated that Kuntai Capsule and E2 partly suppress the apoptosis of follicles. Furthermore, it showed an increased trend of the meiotic-specific cohesin subunits REC8 and SMC1βafter administration with E2 and Kuntai Capsule, and no obvious change in the level of cohesin subunit common to mitotic cells-SMC3.The present results revealed that supplement of Kuntai Capsule in aged mice could enhance the number of follicles, suppress apoptosis of oocytes and have a trend to elevate the meiotic-specific cohesin subunits REC8 and SMC1βin oocytes, which implies a beneficial effect on the ovarian function in terms of the quantity and quality of follicles.

关键词： follicular development cohesin oocyte Kuntai Capsule

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