检索结果-南通市图书馆

Oral microbiota in the oral-genitourinary axis:identifying periodontitis as a potential risk of genitourinary cancers

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Military Medical Research 2021年第4期8卷 564-578页

作者： Shuai Yuan Cheng Fang Wei-Dong Leng Lan Wu Bing-Hui Li Xing-Huan Wang Hailiang Hu Xian-Tao Zeng Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China. Department of Stomatology Taihe HospitalHubei University of MedicineShiyan 442000China. Department of Stomatology Zhongnan Hospital of Wuhan UniversityWuhan 430071China. Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China. Department of Pathology Duke University School of MedicineDurhamNC 27710USA. School of Medicine Southern University of Science and TechnologyShenzhen 518055GuangdongChina.

Periodontitis has been proposed as a novel risk factor of genitourinary cancers:although periodontitis and genitourinary cancers are two totally distinct types of disorders,epidemiological and clinical studies,have established associations between *** of oral microbiota has already been established as a major factor contributing to *** emerging epidemiological evidence and the detection of oral microbiota in genitourinary organs indicate the presence of an oral-genitourinary axis and oral microbiota may be involved in the pathogenesis of genitourinary ***,oral microbiota provides the bridge between periodontitis and genitourinary *** have carried out this narrative review which summarizes epidemiological studies exploring the association between periodontitis and genitourinary *** have also highlighted the current evidence demonstrating the capacity of oral microbiota to regulate almost all hallmarks of cancer,and proposed the potential mechanisms of oral microbiota in the development of genitourinary cancers.

关键词： Oral microbiota Oral-genitourinary axis Periodontitis Urogenital neoplasms Prostatic neoplasms kidney neoplasms Urinary bladder neoplasms

Multicentricity and its associated factors in renal cell carcinoma

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2002年第9期115卷 1341-1344,149页

作者：李泉林关宏伟张秋萍薛军王法鹏宋希双大连医科大学附属第一医院泌尿外科大连116011 大连医科大学附属第一医院病理科大连116011

OBJECTIVE: To investigate the incidence and associated factors of multicentricity in renal cell carcinoma (RCC) in Chinese patients. METHODS: One hundred and two kidney samples from radical nephrectomy due to RCC were step sectioned at 3 mm intervals and examined. All tissue abnormalities were removed, stained and examined for multicentricity. Then, on each slice of the sample, both the parenchymal margin of 15 mm beyond the pseudocapsule and tissue around the renal sinus were continuously sectioned and examined for completeness of the pseudocapsule and vascular and lymph node invasion. The relationship between muliticentricity and other pathological parameters was evaluated. RESULTS: The incidence of multicentricity was 15.7% (16/102); it was significantly lower in primary tumors 4.0 cm (4.9%, 2/41 vs 23.0%, 14/61; chi(2) = 6.055, P = 0.014). The incidence was 9.8% (8/82) in tumors without vascular invasion and 40.0% (8/20) in those with it (P = 0.003, Fisher's exact test). The incidence of multicentricity was 1.9% (1/53) in tumors with a complete pseudocapsule and 30.6% (15/49) in those without it (chi(2) = 15.885, P = 0.000). The grade, stage, subtypes and lymph node invasion of the primary tumor were not significantly associated with multicentricity. Multiple logistic regression analysis showed that pseudocapsular incompleteness and vascular invasion were two significant predictors of RCC multicentricity (P = 0.005 and 0.023). CONCLUSIONS: The incidence of multicentricity of RCC in this group of patients was in accordance with published studies. Multifocality was significantly associated with tumor size, pseudocapsule completeness and vascular invasion. NSS should be limited to tumors less than 4.0 cm when the contralateral kidney is normal and careful long-term follow-up is necessary in tumors with positive vascular invasion and incomplete pseudocapsule.

关键词： Aged Carcinoma, Renal Cell China Female Humans Incidence kidney neoplasms Lymphatic Metastasis Male Middle Aged Neoplasm Invasiveness Research Support, Non-U.S. Gov't

Ipsilateral synchronous renal pelvic transitional cell carcinoma, squamous cell carcinoma and adenocarcinoma

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2004年第10期117卷 1590-1591页

作者：韩平魏强石明杨宇如 Department of Urology West China Hospital Sichuan University Chengdu 610041 China

Reports of multiple synchronous primary renal neoplasms in the literature are rare. Although primary renal tumors of 2 distinctively dissimilar origins have been sporadically described,1-6 to our knowledge there have been no reported cases of triple primary renal neoplasms in the same kidney. Here we report a very rare case of ipsilateral synchronous renal pelvic transitional cell carcinoma, squamous cell carcinoma and adenocarcinoma with marked hydronephrosis and multiple stones in the same kidney.

关键词： Adenocarcinoma Carcinoma, Squamous Cell Carcinoma, Transitional Cell Female Humans kidney neoplasms kidney Pelvis Middle Aged neoplasms, Multiple Primary

Renal cell carcinoma related novel gene, GYLZ-RCC18: cloning and functional studies

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2002年第5期115卷 746-749,155-156页

作者：张强梁丽莉席志军丁义佟明张志文郭应禄李钟陈琳北京大学第一医院北京大学泌尿外科研究所北京100034 美国芝加哥西北大学福建省血液研究所厦门361001

OBJECTIVE: To clone the full length of renal cell carcinoma (RCC) related novel gene GYLZ-RCC18 and study its function. METHODS: SMART RACE technology was used to clone the full length of GYLZ-RCC18. RT-PCR was used to detect its expression in renal cell carcinoma tissue at different stages and grades. We transfected the antisense oligonucleotide of GYLZ-RCC18 to renal cell carcinoma cell line, GRC-1, and analyzed proliferation activity, growth rate, apoptosis, and mortality changes. RESULTS: The full length of GYLZ-RCC18 (GenBank accession number: BE825133) cDNA was about 3.5 kb. GYLZ-RCC18 had a higher expression in higher grades and stages of renal cell carcinoma than in lower ones. The expression of GYLZ-RCC18 in renal cell carcinoma was much higher than in normal kidney. After the transfection of GYLZ-RCC18 antisense oligonucleotide, the mortality of GRC-1 increased significantly, while proliferative activity and growth rate were substantially inhibited at the same time. The antisense oligonucleotide induced apoptosis of GRC-1 through the entire observation time. CONCLUSION: GYLZ-RCC18 is an important novel gene related to renal cell carcinoma. Overexpression of this gene results in higher growth and proliferative activity and has an antiapoptosis effect on renal cell carcinoma cells. Transfection of the antisense oligonucleotide may inhibit the generation and development of renal cell carcinoma.

关键词： Apoptosis Carcinoma, Renal Cell Cell Division Cell Line Cloning, Molecular DNA, Antisense DNA, Complementary Gene Expression Regulation, Neoplastic Genes, Neoplasm Humans kidney neoplasms Neoplasm Proteins Oligonucleotides Research Support, Non-U.S. Gov't Sequence Analysis, DNA Transfection Tumor Cells, Cultured

Detection of the expression of heat shock protein 70 using quantum dots as fluorescence probe in human renal carcinoma

在线全文

学校读者我要写书评

暂无评论

The Chinese-German Journal of Clinical Oncology 2009年第3期8卷 164-167页

作者： Cai Lv Jie Zhang Zhiming Bai Huan Yang Xiaobin Zhang Department of Urology Municipal Hospital of Haikou Haikou 570208 China Department of Urology Renmin Hospital of Wuhan University Wuhan 430060 China

Objective： To detect the expression of heat shock protein 70 （HSP70） in human renal carcinoma tissues and cultured ACHN cells by using quantum dots-tagged fluorescence technology and its significance. Methods： Using the fluorescence property of quantum dots, indirect immunofluorescence method and immunocytochemical method were used to detect the expression of HSP70 tagged by quantum dots in renal carcinoma tissues and ACHN cells cultured in vitro. Results： Confocal fluorescence microscopy showed that HSP70 were significantly expressed in renal carcinoma tissues and ACHN cells cultured in vitro characterized by homogeneous distribution of intensive salmon pink fluorescence. Compared with FITC tagging, quantum dots tagged fluorescence had good specificity and signal to background. There was no notable quenching after excitation by quantum dots for 30 rain. Conclusion： Quantum dots can be used to label subcellular proteins and have obvious advantages compared with the traditional fluorescence methods. The quantum dots-tagged fluorescence could be applied as a new method for clinical labeling detection.

关键词： kidney neoplasms quantum dots HSP70 heat-shock proteins ACHN cells

Nephron-sparing surgery for small renal cell carcinoma

在线全文

学校读者我要写书评

暂无评论

Journal of Nanjing Medical University 2009年第3期23卷 207-211页

作者： Yongsheng Li Shaoxing Zhu Weizhong Cai Shiping Chen Qiyong Li Department of Urology Affiliated Union Hospital of Fujian Medical University Fuzhou 350001 China

Objective：To investigate the method and effect of nephron-sparing surgery in the treatment of small renal cell carcinoma. Methods： From August 1 997 to October 2008, 48 cases of small renal cell carcinomas were confirmed by surgery and pathology, and reviewed retrospectively. Of the 48 cases, there was 1 patient with bilateral tumors, 8 with solitary kidney tumors, 1 with unilateral tumor and a damaged contralateral kidney, and 38 with unilateral tumors and a normal contralateral kidney; 9 underwent tumor enucleation and the remaining patients received partial nephrectomy. Results：There were no local tumor recurrences and/or tumor metastasis at a mean followup of 60 months. Conclusion： Confirming conclusions from other centers, we have found that nephron-sparing surgery is an effective treatment for small renal cell carcinomas.

关键词： small renal cell carcinoma nephron-sparing surgery kidney neoplasms

Preoperative Diagnosis of Solitary Fibrous Tumor of the kidney with Percutaneous Fine Needle Biopsy and Management with Laparoscopic Partial Nephrectomy: One Case Report and Literatures Review

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Clinical Oncology 2008年第6期5卷 453-455页

作者： Liaoyuan Li Yadi He Xin Gao Ming Yang Haibin Zhang Yuanyuan Xu Wenfeng Xu Department of Urology the Third Hospital of Sun Yat-Sen University Guangzhou 510630 Guangdong Province China Department of Pathology Foshan Hospital of Sun Yat-Sen University Foshan 528000 Guangdong Province China Department of Urology Foshan Hospital of Sun Yat-Sen University Foshan 528000 Guangdong ProvinceChina

Introduction Solitary fibrous tumor （SFT） of the kidney is a rare spindle cell neoplasm and all reported SFTs of the kidney were diagnosed through pathological examination and immunohistochemical study after open nephrectomy or open radical nephrectomy. We present a case of SFT of the kidney diagnosed through fine needle core biopsy preoperatively in a 50-year-old female and managed with laparoscopic partial nephrectomy. Due to the difficulty in discriminating between malignant and benign growth pattern of this tumor entity, a regular follow-up after conservative treatment is mandatory.

关键词： kidney neoplasms mesothelioma immunohistochemical staining.

Robot-Assisted Nephrotomy as a Nephron-Sparing Approach for Completely Intraparenchymal Renal Tumors

在线全文

学校读者我要写书评

暂无评论

Open Journal of Urology 2023年第10期13卷 459-467页

作者： Marcos Dall’Oglio Matheus Miranda Paiva Fabrício Golono Kaminagakura José Augusto Farias da Silva Júnior Jorge Ocké Urology Department of the Santa Marcelina Hospital S&#227o Paulo Brazil

Introduction: The diagnosis of small renal masses and the endophytic tumor approach have become challenging. This study aims to describe exclusively robot-assisted surgery as an alternative nephron-sparing approach for renal intraparenchymal tumors. Patients and Methods: We retrospectively analyzed all patients with completely endophytic tumors undergoing robot-assisted partial nephrectomy, treated under the Da Vinci System®, aided by intraoperative ultrasound. The patients’ demographic characteristics, perioperative and oncological outcomes were assessed. Results: From a total of 13 partial nephrectomies performed between 06/2010 and 10/2021, all patients underwent nephrotomy. The patients’ mean age was 52 years and the tumor measured mean 2.6 cm. Warm ischemia time was 24 minutes and histopathological analysis revealed that 12 patients had renal cell carcinoma. In a mean 36-month follow-up, no significant renal function alterations were found and no local or systemic recurrences occurred. Conclusion: Robot-assisted access is a safe and effective option for the nephron-sparing technique in completely intraparenchymal renal tumors.

关键词： Robotic Surgical Procedures kidney neoplasms Organ Sparing Treatment Nephrectomy Renal Mass

A Case Report of Papillary Renal Cell Carcinoma Seeding along a Percutaneous Biopsy Tract

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Pathology 2018年第4期8卷 139-146页

作者： Christine Busset Sandrine Vijgen Benoit Lhermitte Pu Yan Institute of Pathology University of LausanneLausanneSwitzerland

We report a rare case of a papillary renal cell carcinoma seeding along a percutaneous biopsy tract detected at the time of partial nephrectomy in a 51-year-old man with a 3.5 cm renal mass discovered on computed tomography scan (CT scan). Although renal percutaneous biopsy is now considered as an accurate and safe technique to provide valuable diagnostic information for indeterminate renal lesions, some inherent risks have been reported to associate with this procedure. One of the risks is tumor needle tract seeding, which is a very rare complication of renal percutaneous biopsy. Our well-documented case report could provide some useful information to evaluate the prognosis of patients with tumor seeding along a percutaneous biopsy tract.

关键词： kidney neoplasms Biopsy Seeding