Oral microbiota in the oral-genitourinary axis:identifying periodontitis as a potential risk of genitourinary cancers

作     者：Shuai Yuan Cheng Fang Wei-Dong Leng Lan Wu Bing-Hui Li Xing-Huan Wang Hailiang Hu Xian-Tao Zeng Shuai Yuan;Cheng Fang;Wei-Dong Leng;Lan Wu;Bing-Hui Li;Xing-Huan Wang;Hailiang Hu;Xian-Tao Zeng

作者机构：Center for Evidence-Based and Translational MedicineZhongnan Hospital of Wuhan UniversityWuhan 430071China. Department of StomatologyTaihe HospitalHubei University of MedicineShiyan 442000China. Department of StomatologyZhongnan Hospital of Wuhan UniversityWuhan 430071China. Department of UrologyZhongnan Hospital of Wuhan UniversityWuhan 430071China. Department of PathologyDuke University School of MedicineDurhamNC 27710USA. School of MedicineSouthern University of Science and TechnologyShenzhen 518055GuangdongChina. 

出 版 物：《Military Medical Research》 (军事医学研究（英文版）)

年 卷 期：2021年第8卷第4期

页      面：564-578页

核心收录：

学科分类：1003[医学-口腔医学] 1002[医学-临床医学] 100302[医学-口腔临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the Zhongnan Hospital of Wuhan University Science,Technology and Innovation Seed Fund(No.znpy2019011) the Fundamental Research Funds for the Central Universities(No.2042020kf0130) the Nature Science Foundation of Hubei Province(No.2019FFB03902) the Health Commission of Hubei Province Scientific Research Project(No.WJ2019H035) 

主　　题：Oral microbiota Oral-genitourinary axis Periodontitis Urogenital neoplasms Prostatic neoplasms Kidney neoplasms Urinary bladder neoplasms 

摘      要：Periodontitis has been proposed as a novel risk factor of genitourinary cancers:although periodontitis and genitourinary cancers are two totally distinct types of disorders,epidemiological and clinical studies,have established associations between *** of oral microbiota has already been established as a major factor contributing to *** emerging epidemiological evidence and the detection of oral microbiota in genitourinary organs indicate the presence of an oral-genitourinary axis and oral microbiota may be involved in the pathogenesis of genitourinary ***,oral microbiota provides the bridge between periodontitis and genitourinary *** have carried out this narrative review which summarizes epidemiological studies exploring the association between periodontitis and genitourinary *** have also highlighted the current evidence demonstrating the capacity of oral microbiota to regulate almost all hallmarks of cancer,and proposed the potential mechanisms of oral microbiota in the development of genitourinary cancers.