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Neutrophil gelatinase-associated lipocalin,kidney injury molecule-1,and periostin:Novel urinary biomarkers in diabetic nephropathy

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World Journal of Nephrology 2024年第4期13卷 117-124页

作者： Sakthivadivel Varatharajan Vishakha Jain Anand K Pyati Charan Neeradi Kotha Sugunakar Reddy Janardhana Reddy Pallavali Ilakkiya Priya Pandiyaraj Archana Gaur Department of General Medicine All India Institute of Medical Sciences-BibinagarHyderabad 508126TelanganaIndia Department of Biochemistry All India Institute of Medical Sciences-BibinagarHyderabad 508126TelanganaIndia Department of General Medicine Neelima Institute of Medical SciencesHyderabad 500088TelanganaIndia Department of Physiology All India Institute of Medical Sciences-BibinagarHyderabad 508126TelanganaIndia

BACKGROUND Globally,diabetic nephropathy(DN)is the primary cause of chronic kidney ***,renal function is monitored indirectly using measures of serum creatinine,estimated glomerular filtration rate(eGFR),and *** urinary biomarkers utilized in the early stages of DN have been described;these indicators can be used in the early identification of the disease,which is important for initiating treatment to halt or impediment the advance of diabetic *** To estimate neutrophil gelatinase-associated lipocalin(NGAL),kidney injury molecule-1(KIM-1),and periostin(POSTN)levels as novel urinary biomarkers in *** In this hospital based cross-sectional study,a total of 160 patients of both genders aged 18 years or more;40 healthy participants and 120 patients with diabetes mellitus(DM)were *** with DM were divided into normoalbuminuria(n=40),microalbuminuria(n=40),and macroalbuminuria(n=40)groups as per urine albumin creatinine ratio(uACR).Blood urea,serum creatinine,uACR were *** NGAL,KIM-1,and POSTN were measured by enzyme linked immunosorbent *** eGFR was calculated and compared with urinary *** NGAL,KIM-1,and POSTN levels increased significantly in normo,micro,and macroalbuminuria with the highest in the macroalbuminuria *** creatinine ratio(ACR)showed a positive correlation with NGAL,KIM-1,and POSTN *** eGFR showed a weak negative correlation with ACR,NGAL,KIM-1,and *** was significantly lower in stage 1 compared to stage 2,3,and 4 kidney ***-1 was significantly decreased in stage 1 compared to stage 4 kidney *** was significantly decreased in stage 1 compared to stage 3 and 4 kidney *** receiver operator curve analysis of ACR,NGAL,KIM-1,and POSTN showed good sensitivity of 80%,75.8%,63.3%,and 80%respectively with a cut-off of 12.5 mg/g,4.5μg/L,1.5 ng/mL,and 37.5 ng/*** Urinary NGAL and POSTN are independent markers of DN.

关键词： Diabetic nephropathy Neutrophil gelatinase-associated lipocalin kidney injury molecule-1 Periostin Urinary marker

Urine microscopy and neutrophilelymphocyte ratio are early predictors of acute kidney injury in patients with urinary tract infection

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Asian Journal of Urology 2021年第2期8卷 220-226页

作者： Sreerag Kana Rajesh Nachiappa Ganesh Deepanjali Surendran Rajendra G.Kulkarni Ravi Kishore Bobbili Jose Olickal Jeby Department of Pathology Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherryIndia Department of Medicine Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherryIndia Department of Immunohaematology and Transfusion Medicine Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherryIndia Department of Preventive and Social Medicine Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherryIndia

Objective:Urinary tract infection(UTI)is a common cause of morbidity and hospitalisation in the population *** UTI is indolent and causes subclinical acute kidney injury(AKI)resulting in preventable cause of scarring of renal *** explored urinary and serum levels of kidney injury molecule-1(KIM-1),haematological parameters and quantitative urine microscopy parameters to predict kidney ***:Neutrophilelymphocyte ratio(NLR)is obtained by dividing absolute neutrophil count with absolute lymphocyte *** urine sediment microscopy was performed and correlated with clinical,biochemical and haematological findings to predict AKI in patients with *** ELISA was performed for serum and urine levels of *** two adult patients with UTI were enrolled,45 of whom had AKI while 27 were in the non-AKI ***:NLR(p=0.005)and renal tubular epithelial cell-granular cast score in quantitative urine microscopy(p=0.008)are strong predictors of AKI in patients with UTI while rest of quantitative urine microscopy parameters and serum and urinary levels of KIM-1 molecule were not found to be useful in prediction of ***:NLR in haemogram is a novel and useful biomarker for predicting AKI in patients with UTI.

关键词： Acute kidney injury kidney injury molecule-1 Neutrophil elymphocyte ratio Quantitative urine microscopy score Urinary tract infection

Mitsugumin 53 protects the kidney from severe burn injury in mice

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Burns & Trauma 2013年第3期1卷 128-133页

作者： Yanjun Wu Jian Huang Daisong Liu Jianglin Tan Yanmeng Peng Junjie Yang Yanyan Cui Weifeng He Gaoxing Luo Jun Wu Institute of Burn Research Southwest Hospital Third Military Medical University Chongqing Department of Urinary Surgery Chengdu Seventh People's Hospital Chengdu tumor hospital Chengdu China

Mitsugumin 53 (MG53), a newly identified muscle-specific protein, is an essential component of the cell membrane repair machinery in skeletal and cardiac muscle. However, the role of MG53 after burns in other tissues remains unclear. This study aims to investigate the possible roles of MG53 in the protection of the kidney after severe burn injury, and an animal scalding model of 30% of total body surface area (TBSA) was used. Recombinant human MG53 (rhMG53) or bovine serum albumin (BSA) was injected intravenously via the tail vein. Data showed that the mortality in the MG53-treated group was lower than that in control group. Administration of rhMG53 may alleviate histological alterations in renal tubular epithelial cells after burn injury. Renal tubular injury scores and the average optical density score of kidney injury molecule-1 (KIM-1) immunohistochemical staining in the MG53-treated group were significantly lower than those in control group (P kidney after severe scalding. In conclusion, our data indicate that MG53 protein protects the kidney by involving local PTRF after severe burn injury.

关键词： Burn injury recombinant human Mitsugumin53 kidney polymeraseⅠand transcript release factor kidney injury molecule-1

Sickle cell nephropathy:A review of novel biomarkers and their potential roles in early detection of renal involvement

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World Journal of Clinical Pediatrics 2022年第1期11卷 14-26页

作者： Osama Y Safdar Rana M Baghdadi Sereen A Alahmadi Bana E Fakieh Amaal M Algaydi of Pediatric King Abdulaziz UniversityJEDDAH 21414Saudi Arabia College of Medicine King Abdulaziz UniversityJEDDAH 21422Saudi Arabia

Whether the underlying mutations are homozygous,heterozygous,or coinherited with other hemoglobinopathies,sickle cell disease is known to afflict the kidneys,leading to the clinical entity known as sickle cell nephropathy(SCN).Although common,SCN remains diagnostically *** studies performed in the context of renal disorders often fail to detect early stage *** makes the quest for early diagnosis and treatment more challenging,and it increases the burden of chronic kidney disease-related morbidity among *** diagnostic tools have been employed to overcome this *** this study,we discuss various biomarkers of SCN,including those employed in clinical practice and others recently identified in experimental settings,such as markers of vascular injury,endothelial dysfunction,tubulo-glomerular damage,and oxidative *** include kidney injury molecule-1,monocyte chemoattractant protein-1,N-acetyl-B-D-glucosaminidase,ceruloplasmin,orosomucoid,nephrin,and cation channels,among ***,we explore the potential of novel biomarkers for refining diagnostic and therapeutic approaches and describe some obstacles that still need to be *** highlight the importance of a collaborative approach to standardize the use of promising new ***,we outline the limitations of conventional markers of renal damage as extensions of the pathogenic process occurring at the level of the organ and its functional subunits,with a discussion of the expected pattern of clinical and biochemical progression among patients with SCN.

关键词： Sickle cell disease Sickle cell nephropathy Chronic kidney disease kidney injury molecule-1 Monocyte chemoattractant protein-1 N-acetyl-B-D-glucosaminidase

Value of urine IL-8, NGAL and KIM-1 for the early diagnosis of acute kidney injury in patients with ureteroscopic lithotripsy related urosepsis

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Chinese Journal of Traumatology 2022年第1期25卷 27-31页

作者： Dan Tan Liang Zhao Wei Peng Fang-Hao Wu Guo-Bin Zhang Bo Yang Wen-Qian Huo Department of Urology The General Hospital of Chongqing Steel CompanyChongqing400081China

Purpose::To investigate the clinical value of urine interleukin-18(IL-8),neutrophil gelatinase-associated lipocalin(NGAL)and kidney injury molecule-1(KIM-1)for the early diagnosis of acute kidney injury(AKI)in patients with ureteroscopic lithotripsy(URL)related ***::A retrospective study was carried out in 157 patients with urosepsis after *** patients were divided into AKI group and non-AKI group according to the Kidigo guideline and urine IL-8,NGAL and KIM-1 levels were detected by enzyme-linked immunosorbent assay at 0,4,12,24 and 48 h after the *** operating characteristic curve(ROC)was used to evaluate the diagnostic value of these three biomarkers for postoperative ***::The level of urine IL-8,NGAL and KIM-1 in AKI group was significantly higher than that in non-AKI group at 4,12,24 and 48 h(p<0.01).The ROC analysis showed the combined detection of urine IL-8,NGAL and KIM-1 at 12 h had a larger area under curve(AUC)than a single marker(0.997,95%CI:0.991-0.998),and the sensitivity and specificity were 98.2%and 96.7%,*** correlation analysis showed that the levels of urine NGAL at 4,12,24 and 48 h in AKI patients were positively correlated with the levels of urine KIM-1 and IL-18(p<0.01).Conclusion::AKI could be quickly recognized by the elevated level of urine IL-8,NGAL and KIM-1 in patients with URL-related *** detection of the three urine biomarkers at 12 h after surgery had a better diagnostic performance,which may be an important reference for the early diagnosis of AKI.

关键词： Urosepsis Ureteroscopic lithotripsy Acute kidney injury Early diagnosis lnterleukin-18 Neutrophil gelatinase-associated lipocalin kidney injury molecule-1