检索结果-南通市图书馆

Chemical profiling of jinqi jiangtang tablets by HPLC-ESI-Q-TOF/MS

Chinese Journal of Natural Medicines 2014年第3期12卷 229-240页

作者： SUN Shi XIE Zhi-Shen LIU E-Hu YAN Yu-Ting XU Xiao-Jun LI Ping State Key Laboratory of Natural Medicines China Pharmaceutical University

AIM： To profile the chemical constituents in jinqi jiangtang tablets. METHOD： Based on the chromatographic retention behavior, fragmentation patterns of chemical components, and published lit- eratures, a high-performance liquid chromatography coupled with electrospray ionization quadrnpole time-of-flight tandem mass spectrometry （HPLC-ESI-Q-TOF/MS） method was established to characterize and identify components in jinqi jiangtang tablets. RESULTS： A total of 52 chemical compounds, including eight iridoid glycosides, seven phenolic acids, twelve alkaloids, six fla- vonoids, and nineteen saponins, were identified in jinqi jiangtang tablets. CONCLUSION： The established method could serve as a powerful tool for structural characterization and quality control of this Chinese herbal preparation.

关键词： HPLC-ESI-Q-TOF/MS Coptidis Rhizoma Astragali Radix Lonicerae Japonicae Flos jinqi jiangtang tablets Massspectrometry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Integration of network pharmacology with experimental verification reveals the hypoglycemic mechanism of coptisine in jinqi jiangtang tablets:inhibition of the FoxO1 signaling pathway and hepatic gluconeogenesis

引用

Traditional Medicine Research 2023年第3期8卷 51-61页

作者： Hang Gong Yu-Cai Chen Jia-Qi Xie Yi-Hong Li Li-Dan Cui Hong-Tao Jin Can Wang School of Chinese Materia Medica/School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China New Drug Safety Evaluation Center Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Beijing Union-Genius Pharmaceutical Technology Development Co.Ltd. Beijing 100176China

Background:jinqi jiangtang tablets(JQJT)have been approved for the treatment of type 2 diabetes mellitus(T2DM)in China for many *** the effective substances and mechanisms of JQJT is important for its clinical application and further drug research and *** study aimed to explore the chemical basis and mechanisms of JQJT in the treatment of ***:With network pharmacology,we screened substances in JQJT and their possible targets,then constructed the action network and enriched the biological functions and pathways associated with the active components,and identified the potential targets and mechanisms of JQJT in the treatment of *** on the network pharmacology data,we explored the hypoglycemic mechanisms of coptisine in JQJT through western blot and quantitative real-time polymerase chain ***:Forty-three compounds with good pharmacokinetic properties were identified in JQJT,together with 146 potential biological *** these potential targets,74 were associated with treatment of T2DM.A compound-target network of the 43 compounds against T2DM was *** process and signal pathway enrichment analysis of the network highlighted the FoxO signaling *** blot and quantitative real-time polymerase chain reaction results showed that coptisine,but not epiberberine,significantly inhibited expression of key genes involved in hepatocyte gluconeogenesis by regulating the FoxO1 signaling ***:Network pharmacology analysis and cell experiments showed that coptisine regulated glucose homeostasis by inhibiting the FoxO1 signaling pathway and hepatic gluconeogenesis,which may be one of the mechanisms of JQJT in the treatment of T2DM.

关键词： jinqi jiangtang tablets FoxO1 gluconeogenesis type 2 diabetes mellitus network pharmacology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：