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NIR-Ⅱ responsive janus nanoparticles amplify immunogenic cell death for enhanced cancer immunotherapy

Science China(Technological Sciences) 2024年第1期67卷 321-329页

作者： CHEN BeiBei GUO KangLi WANG HaoRan XU Fu-Jian WANG JuLin ZHAO NaNa State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China Key Laboratory of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical Technology) Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing 100029China College of Materials Sciences and Engineering Beijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Electrochemical Process and Technology for Materials Beijing University of Chemical TechnologyBeijing 100029China

Immunotherapy brings new hope for tumor treatment by inducing immunogenic cell death(ICD)of tumor ***,insufficient immunogenicity and low immune response rate greatly limit antitumor ***,by optimizing the composition and morphology,the rational design of janus nanoparticles composed of Fe_(3)O_(4) nanospheres and SiO_(2)nanorods was realized for enhanced cancer immunotherapy through amplified *** glucose oxidase(GOx)was loaded by the janus nanoparticles,the resultant M-FS-GOx consumes glucose at tumor sites to generate gluconic acid and hydrogen peroxide(H_(2)O_(2))for starvation therapy while the H_(2)O_(2)supply promotes the production of highly toxic·OH to achieve effective chemodynamic therapy(CDT).Under a 1064 nm light irradiation,the photothermal effect of M-FS-GOx enhances the enzyme activity of GOx for improved starvation ***,both tumor-associated antigens released during the process of ICD and the intrinsic immunoadjuvant property of M-FS-GOx stimulate dendritic cell maturation to activate antitumor immune *** work provides a promising strategy for the construction of janus nanoparticles to achieve enhanced cancer immunotherapy through combination therapy-amplified ICD.

关键词： janus nanoparticles immunogenic cell death cancer immunotherapy

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Unraveling the influence of surface roughness on oil displacement by janus nanoparticles

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Petroleum Science 2023年第4期20卷 2512-2520页

作者： Yuan-Hao Chang Sen-Bo Xiao Rui Ma Zhi-Liang Zhang Jian-Ying He Department of Structural Engineering Norwegian University of Science and Technology(NTNU)7491TrondheimNorway

janus nanoparticles(JNPs)possess great potential in recovering the residual oil from reservoirs,however,the fundamental interaction mechanisms among nanoparticles,the oil,and reservoir wall characteristics remain to be *** this work,models of oil trapping grooves with different geometric features are subjected to molecular dynamics simulations for investigating the influences of roughness parameters on oil displacement dynamics by *** key surface geometry parameters and different degrees of surface hydrophobicity are *** results indicate that JNPs hold an outstanding performance in displacing residual oil on weakly to moderately hydrophobic ***,smaller entry and exit angles,the larger aspect ratio of the oil trapping grooves,and a bigger tip length of the rough ridges lead to superior oil *** the key geometric parameters,the aspect ratio of the oil trapping grooves plays the dominant *** insights about the interaction of surface properties and JNPs and the resulting trapped oil displacement could serve as a theoretical reference for the application of JNPs for targeted reservoir conditions.

关键词： janus nanoparticles Oil displacement Enhanced oil recovery Molecular dynamics simulation Rough surface

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The construction of pseudo-janus silica/surfactant assembly and their application to stabilize Pickering emulsions and enhance oil recovery

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Frontiers of Chemical Science and Engineering 2022年第7期16卷 1101-1113页

作者： Han Jia Jiajun Dai Tingyi Wang Yingbiao Xu Lingyu Zhang Jianan Wang Lin Song Kaihe Lv Dexin Liu Pan Huang Shandong Key Laboratory of Oilfield Chemistry School of Petroleum EngineeringChina University of Petroleum(East China)Qingdao 266580China Key Laboratory of Unconventional Oil&Gas Development(China University of Petroleum(East China)) Ministry of EducationQingdao 266580China Technology Inspection Center Shengli Oilfield CompanySINOPECDongying 257000China Department of Chemical and Materials Engineering University of Alberta EdmontonAB T6G 1H9Canada

nanoparticles with high surface energy and chemical activity have drawn substantial attention in petroleum industry. Recently, janus nanoparticles exhibited tremendous potential in enhanced oil recovery (EOR) due to their asymmetric structures and properties. In this study, a series of amphiphilic pseudo-janus@OTAB (PJ@C18) nanoparticles with different concentrations of stearyltrimethylammoium bromide (OTAB) were successfully fabricated. The structures and properties of PJ@C18 were characterized by Fourier transform infrared spectroscopy and ζ-potential measurements. Based on the emulsification experimental results, the interaction models and the self-assembly behavior between hydrophilic nanoparticles (SiO_(2)@NH_(2)) and OTAB molecules at the oil/water interface were proposed, which was further confirmed via the measurements of the contact angle and dynamic interfacial tension. Interestingly, it was found that the change of pH value from 7.5 to 4.0 caused the type reversal of the PJ@C18-1000 stabilized Pickering emulsions. Furthermore, the PJ@C18-1000 stabilized Pickering emulsion system with excellent salt and temperature tolerances (10000 mg∙L^(–1), 90℃) significantly improved the oil recovery in the single-tube (more than 17%) and double-tube (more than 25%) sand pack model flooding tests. The findings of this study could help to better understand the construction mechanism of pseudo-janus silica/surfactant assembly and the potential application of PJ@C18-1000 stabilized Pickering emulsions for EOR.

关键词： janus nanoparticles surfactant double phase inversion self-assembly enhanced oil recovery

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Au-Fe_3O_4 heterostructures for catalytic, analytical, and biomedical applications

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Chinese Chemical Letters 2018年第12期29卷 1725-1730页

作者： Baoling Liu Hongchen Zhang Ya Ding Key Laboratory of Drug Quality Control and Pharmacovigilance China Pharmaceutical University Beijing Key Laboratory of Magnetoelectric Materials and Devices (BKL-MEMD) Beijing Innovation Center for Engineering Science and Advanced Technology(BIC-ESAT)Department of Materials Science and EngineeringCollege of EngineeringPeking University

Heterostructures are a series of nanomaterials combining different components into a single nanostructure. Au-FeOheterostructures have received considerable attentions because of their superior properties coming from both individual and combinational features of gold and iron oxide nanoparticles. Their intrinsically peculiar magnetic, optical properties, and structure designability greatly enhance and broaden their potential applications in catalysis, assay, multimodal imaging, and synergistic treatment for tumor. In this review, we systematically introduce the preparation methods of Au-FeOheterostructures and their potential applications in the biomedical field, focusing on the unique synergistic effect caused by the combination of gold and iron oxide structures. This review will provide insights into the structure control in adjusting the function of heterogeneous or hybrid material, such as Au-FeOheterostructures, to implement their biomedical applications.

关键词： Au-Fe_3O_4 heterostructures janus nanoparticles Catalyst Multimodal imaging Synergistic treatment

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janus γ-Fe2O3/SiO2-based nanotheranostics for dual-modal imaging and enhanced synergistic cancer starvation/chemodynamic therapy

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Science Bulletin 2020年第7期65卷 564-572,M0004页

作者： Yifan Zhang Yilin Wan Yunyan Liao Yanjie Hu Tao Jiang Ting He Wei Bi Jing Lin Peng Gong Longhua Tang Peng Huang Marshall Laboratory of Biomedical Engineering International Cancer CenterLaboratory of Evolutionary Theranostics(LET)School of Biomedical EngineeringShenzhen University Health Science CenterShenzhen 518060China State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China Department of General Surgery Shenzhen University General HospitalShenzhen 518055China

Multimodal cancer synergistic therapy exhibited remarkable advantages over monotherapy in producing an improved therapeutic efficacy. In this work, janus-type γ-Fe2 O3/SiO2 nanoparticles(JFSNs) are conjugated with glucose oxidase(GOx) for synergistic cancer starvation/chemodynamic therapy. The γ-Fe2O3 hemisphere of JFSNs can perform photoacoustic/T2 magnetic resonance dual-modal imaging of *** on the surface of JFSNs catalyzes the decomposition of glucose and produces H2O2 for cancer starvation therapy. Subsequently, the γ-Fe2O3 hemisphere catalyzes the disproportionation of H2O2 to generate highly reactive hydroxyl radicals in an acidic tumor microenvironment. The close distance between GOx and JFSNs ensures adequate contact between the γ-Fe2O3 hemisphere and its substrate H2O2, thus enhancing the catalytic efficiency. This synergy of glucose depletion, biotoxic H2O2 and hydroxyl radicals significantly suppresses 4 T1 mammary tumor growth with minimal adverse effects.

关键词： Synergistic therapy janus nanoparticles Glucose oxidase Fenton-like reaction Theranostics

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