Janus γ-Fe2O3/SiO2-based nanotheranostics for dual-modal imaging and enhanced synergistic cancer starvation/chemodynamic therapy

作     者：Yifan Zhang Yilin Wan Yunyan Liao Yanjie Hu Tao Jiang Ting He Wei Bi Jing Lin Peng Gong Longhua Tang Peng Huang 张一帆;万艺林;廖云燕;胡彦杰;江涛;贺婷;毕炜;林静;巩鹏;唐龙华;黄鹏

作者机构：Marshall Laboratory of Biomedical EngineeringInternational Cancer CenterLaboratory of Evolutionary Theranostics(LET)School of Biomedical EngineeringShenzhen University Health Science CenterShenzhen 518060China State Key Laboratory of Modern Optical InstrumentationCollege of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory for Ultrafine Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China Department of General SurgeryShenzhen University General HospitalShenzhen 518055China 

出 版 物：《Science Bulletin》 (科学通报（英文版）)

年 卷 期：2020年第65卷第7期

页      面：564-572,M0004页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by the National Key Research and Development Program of China(2018YFA0704003) the Basic Research Program of Shenzhen(JCYJ20180305163452667,JCYJ20180507182413022,and JCYJ20170412111100742) the National Natural Science Foundation of China(81903564,31771036,51703132,and 21874119) the Guangdong Provincial Natural Science Foundation of Major Basic Research and Cultivation Project(2018B030308003) the Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China(161032) We thank Instrumental Analysis Center of Shenzhen University(Lihu Campus) 

主　　题：Synergistic therapy Janus nanoparticles Glucose oxidase Fenton-like reaction Theranostics 

摘      要：Multimodal cancer synergistic therapy exhibited remarkable advantages over monotherapy in producing an improved therapeutic efficacy. In this work, Janus-type γ-Fe2 O3/SiO2 nanoparticles(JFSNs) are conjugated with glucose oxidase(GOx) for synergistic cancer starvation/chemodynamic therapy. The γ-Fe2O3 hemisphere of JFSNs can perform photoacoustic/T2 magnetic resonance dual-modal imaging of *** on the surface of JFSNs catalyzes the decomposition of glucose and produces H2O2 for cancer starvation therapy. Subsequently, the γ-Fe2O3 hemisphere catalyzes the disproportionation of H2O2 to generate highly reactive hydroxyl radicals in an acidic tumor microenvironment. The close distance between GOx and JFSNs ensures adequate contact between the γ-Fe2O3 hemisphere and its substrate H2O2, thus enhancing the catalytic efficiency. This synergy of glucose depletion, biotoxic H2O2 and hydroxyl radicals significantly suppresses 4 T1 mammary tumor growth with minimal adverse effects.