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Safety evaluation of Eugenia jambolana seed extract

Asian Pacific Journal of Tropical Medicine 2010年第12期3卷 982-987页

作者： Jayanta M Sankhari Ravirajsinh NJadeja Menaka C Thounaojam Ranjitsinh V Devkar Raniachandran AV Division of Phytotherapeutics and Metabolic Endocrinology Department of ZoologyFaculty of ScienceThe MS University of BarodaVadodara-390002GujaratIndia

Objective:To evaluate the safety of ethanolic seed extract of Eugenia jambolana（EJSE） using acute and sub-chronic toxicity assays in Swiss albino mice as per Organisation for Economic Co-operation and Development（OECD） ***:Possible behavioral changes and lethality were observed in mice administered a single dose[1 000,2 000,3 000,4 000 or 5 000mg/kg body weight（BW）]of EJSE,Plasma levels of metabolic,hepatic,cardiac and renal function markers, electrolytes,blood count and histopathology of major organs were monitored in mice chronically treated with EJSE（1 000,2 000 or 3 000 mg/kg BW） for 28 ***:Since no mortality was recorded in the acute toxicity evaluation up to a dose of 5 000 mg/kg bodyweight of EJSE,50% lethal dose(LD50) was assumed to be >5 000 mg/kg *** the sub-chronic toxicity evaluation, no adverse observations were recorded in mice administered with 2 000 mg/kg BW of EJSE; however at 3 000 mg/kg BW dose,moderately significant increase in the plasma levels of urea and creatinine was ***,the lowest observable adverse effect level（LOAEL） for EJSE was found to be 3 000 mg/kg BW and the no observable adverse effect level（NOAEL） was adjudged as 2 000 mg/kg ***:It can be concluded from this study that,orally administered EJSE is safe up to a10 fold higher dose than its reported therapeutic dose.

关键词： Acute toxicity Sub chronic toxicity Eugenia jambolana NOAEL LOAEL

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Laxative Effect of Eugenia jambolana Crude Leaf Bud Extract

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Pharmacology & Pharmacy 2011年第3期2卷 164-167页

作者： A Sivakumar T.Panneer Selvam School of Bio Science and Technology VIT University Vellore-632 014 Tamilnadu India

The therapeutic value of Eugenia jambolana Lam. commonly known as ‘Jamun’ has been recognized in different system of traditional medication for the treatment of different diseases and ailments. It contains several phytoconstituents belonging to category of alkaloids, glucosides, flavonoides and volatile oils. It has been reported as digestive, astringent to the bowels, anthelmintic, sore throat, bronchitis, asthma, thirst, biliousness, dysentery, blood purifier, ulcers and diabetes. There are few reports available on clinical uses of Eugenia jambolana in diabetes that have shown promising results. In south India ayurvedic practitioners were using the leaf buds of Eugenia jambolana to induce laxative effect and to clean up the intestinal contents before starting any medication. The result showed that of E. jambolana stimulates the contractile action of frog and mice through an acetylcholine-like mechanism and effectively stimulates gastrointestinal motility in mice and frogs. In this paper we have discussed the laxative effect of Eugenia jambolana leaf bud extract which was never reported scientifically.

关键词： Eugenia jambolana Traditional Medicine Laxative

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Syzygium cumini(L.)Skeels:A review of its phytochemical constituents and traditional uses

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Asian Pacific Journal of Tropical Biomedicine 2012年第3期2卷 240-246页

作者： Muniappan Ayyanar Pandurangan Subash-Babu Department of Botany Pachaiyappa's College Molecular Biology Research Lab Department of Food Science and NutritionCollege of Food and Agriculture ScienceKing Saud University

Syzygium cumini(***)(L.) Skeels(jambolan) is one of the widely used medicinal plants in the treatment of various diseases in particular *** present review has been primed to describe the existing data on the information on botany,phytochemical constituents,traditional uses and pharmacological actions of ***(L.) Skeels(jambolan).Electronic database search was conducted with the search terms of Eugenia jambolana,***,jambolan,common plum and java *** plant has been viewed as an antidiabetic plant since it became commercially available several decades *** last four decades,numerous folk medicine and scientific reports on the antidiabetic effects of this plant have been cited in the *** plant is rich in compounds containing anthocyanins,glucoside,ellagic acid,isoquercetin,kaemferol and *** seeds are claimed to contain alkaloid,jambosine,and glycoside jambolin or antimellin,which halts the diastalic conversion of starch into *** vast number of literatures found in the database revealed that the extracts of different parts of jambolan showed significant pharmacological *** suggest that there is a need for further investigation to isolate active principles which confer the pharmacological *** identification of such active compounds is useful for producing safer drugs in the treatment of various ailments including diabetes.

关键词： Syzygium cumini Medicinal uses Myrtaceae Phytochemistry Traditional uses Jambolan Common plum Java plum Eugenia jambolana

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