Safety evaluation of Eugenia jambolana seed extract
Safety evaluation of Eugenia jambolana seed extract作者机构：Division of Phytotherapeutics and Metabolic EndocrinologyDepartment of ZoologyFaculty of ScienceThe MS University of BarodaVadodara-390002GujaratIndia
出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)
年 卷 期：2010年第3卷第12期
页 面：982-987页
核心收录：
学科分类：090603[农学-临床兽医学] 1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 09[农学] 0906[农学-兽医学] 100602[医学-中西医结合临床] 10[医学]
基 金：University Grants Commission New Delhi for providing Financial Assistance in the form of RFSMS scholarship
主 题：Acute toxicity Sub chronic toxicity Eugenia jambolana NOAEL LOAEL
摘 要：Objective:To evaluate the safety of ethanolic seed extract of Eugenia jambolana（EJSE） using acute and sub-chronic toxicity assays in Swiss albino mice as per Organisation for Economic Co-operation and Development（OECD） ***:Possible behavioral changes and lethality were observed in mice administered a single dose[1 000,2 000,3 000,4 000 or 5 000mg/kg body weight（BW）]of EJSE,Plasma levels of metabolic,hepatic,cardiac and renal function markers, electrolytes,blood count and histopathology of major organs were monitored in mice chronically treated with EJSE（1 000,2 000 or 3 000 mg/kg BW） for 28 ***:Since no mortality was recorded in the acute toxicity evaluation up to a dose of 5 000 mg/kg bodyweight of EJSE,50% lethal dose(LD50) was assumed to be 5 000 mg/kg *** the sub-chronic toxicity evaluation, no adverse observations were recorded in mice administered with 2 000 mg/kg BW of EJSE; however at 3 000 mg/kg BW dose,moderately significant increase in the plasma levels of urea and creatinine was ***,the lowest observable adverse effect level（LOAEL） for EJSE was found to be 3 000 mg/kg BW and the no observable adverse effect level（NOAEL） was adjudged as 2 000 mg/kg ***:It can be concluded from this study that,orally administered EJSE is safe up to a10 fold higher dose than its reported therapeutic dose.
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