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The Anterior Insula and its Projection to the Prelimbic cortex are Involved in the Regulation of 5-HT-Induced itch

Neuroscience Bulletin 2023年第12期39卷 1807-1822页

作者： Juan Yao Xuan Li Guang-Yan Wu Bing Wu Jun-Hui Long Pu-Jun Wang Shu-Lei Liu Jie Gao Jian-Feng Sui Experimental Center of Basic Medicine Army Medical UniversityChongqing400038China Department of Physiology College of Basic Medical SciencesArmy Medical UniversityChongqing400038China Department of Dermatology The 958th Army Hospital of the People’s Liberation ArmyChongqing400020China State Key Laboratory of Trauma Burns and Combined InjuryArmy Medical Centre of the PLAInstitute of Surgery ResearchDaping HospitalArmy Medical UniversityChongqing400042China

itch is an unpleasant sensation that urges people and animals to *** studies on itch have yielded extensive correlations with diverse cortical and subcortical regions,including the insular ***,the role and functional specificity of the insular cortex(IC)and its subdivisions in itch mediation remains ***,we demonstrated by immunohistochemistry and fiber photometry tests,that neurons in both the anterior insular cortex(AIC)and the posterior insular cortex(PIC)are activated during acute itch *** experiments revealed that nonselective inhibition of global AIC neurons,or selective inhibition of the activity of glutaminergic neurons in the AIC,reduced the scratching behaviors induced by intradermal injection of 5-hydroxytryptamine(5-HT),but not those induced by compound 48/***,both nonselective inhibition of global PIC neurons and selective inhibition of glutaminergic neurons in the PIC failed to affect the itching-scratching behaviors induced by either 5-HT or compound 48/*** addition,pharmacogenetic inhibition of AIC glutaminergic neurons effectively blocked itch-associated conditioned place aversion behavior,and inhibition of AIC glutaminergic neurons projecting to the prelimbic cortex significantly suppressed 5-HT-evoked *** findings provide preliminary evidence that the AIC is involved,at least partially via aversive emotion mediation,in the regulation of 5-HT-,but not compound 48/80-induced itch.

关键词： itch-insular cortex Prelimbic cortex Conditioned place aversion Pharmacogenetic inhibition

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