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inula britannica amel.orates al.ohol.induced l.ver injury by modul.ting SIRT1-AMPK/Nrf2/NF-κB signal.ng pathway

Chinese Herbal.Medicines 2024年第4期16卷 667-678页

作者： Zhennan Meng Mengyuan l. Xiaol. Wang Kuo Zhang Chunfu Wu Xiaoshu Zhang Facul.ty of Functional.Food and Wine Shenyang Pharmaceutical UniversityShenyang 110016China School.of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China

Objective: inula britannica is a traditional.Chinese medicinal.and functional.food with various effects such as anti-l.ver injury, hypogl.cemia, antioxidants, and anti-tumor. The aim of this study was to investigate the protective effects and mechanisms of the ethanol.c extract of I. britannica(EEIB) on al.ohol.induced l.ver injury in ***: Fifty-six femal. C57Bl.6 mice were randoml. divided into seven groups: control.group(Con),ethanol.feeding model.group(EtOH), Sil.binin positive treatment group(EtOH + Sil.binin 100 mg/kg),EEIB treatment group(EtOH + EEIB 100, 200, and 400 mg/kg), and EEIB control.group(EEIB 400 mg/kg). The National.Institute on Al.ohol.Abuse and Al.ohol.sm(NIAAA) ethanol.feeding model.was used to study the effects of EEIB on al.ohol.induced l.pid metabol.sm, infl.mmation, oxidative stress, and fibril.formation in mice by histopathol.gical.eval.ation, immunofl.orescence staining, Western bl.tting anal.sis and mol.cul.r ***: EEIB reduced l.ver indices to different degrees to normal.l.vel. and improved l.ver morphol.gy in mice. EEIB inhibited al.ohol.induced l.ver injury by activating the sirtuin 1(SIRT1)-adenosine monophosphate-activated protein kinase(AMPK) signal.ng pathway in the l.ver of al.ohol.fed mice, in which sesquiterpenes may be the potential.active ingredients, and al.o down-regul.ted the expression of al.ha-smooth muscl. actin(a-SMA), col.agen al.ha(Col.agen I), tumor necrosis factor-al.ha(TNFa) and attenuated al.ohol.induced l.ver injury. In addition, EEIB al.o activated the nucl.ar factor erythroid 2-rel.ted factor 2(Nrf2) signal.ng pathway, which al.eviated al.ohol.induced l.ver injury at the l.vel.of oxidative stress. Notabl., the EEIB control.group demonstrated that EEIB had no toxic effects in mice. EEIB reduced al.ohol.c l.ver injury in a dose-dependent manner. Its therapeutic efficacy was comparabl. to, if not better than, that of Sil.binin when administered at a dose of 400 mg/***: EEIB showed sig

关键词： al.ohol.c l.ver injury infl.mmation inula britannica l. sesquiterpenes SIRT1-AMPK/Nrf2

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