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Comparison of the Concentrations of Lidocaine in Different Body Fluids/Tissues after Subarachnoid Space and intravenous administration of a Lethal Dose of Lidocaine

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Journal of Forensic Science and Medicine 2015年第1期1卷 48-53页

作者： Nan Zhang JunHong Sun Zhiwen Wei Wenyan He Guohua Jin Xiaohong Zhang Pengxiang Gao Longmei Wang Keming Yun School of Forensic Medicine Shanxi Medical UniversityTaiyuanChina

The objective of the study was to compare the concentration of lidocaine in different body fluids/tissues after subarachnoid space and intravenous administrations of a lethal dose of *** 18 dogs were used in the *** dogs were given subarachnoid anesthesia,another were given an intravenous injection of a dose of 75 mg/kg weight of lidocaine hydrochloride in 5 min and the last 6 dogs were used as the blank control dogs and given a subarachnoid space injection or a femoral artery injection of the same volume of sodium *** soon as its vital signs disappeared,each dog was dissected and the specimen,such as brain,cerebrospinal fluid(CSF)in lateral ventricle,CSF in subarachnoid space,spinal cord(cervical spinal cord,thoracic spinal cord,lumbar spinal cord,and waist spinal cord),heart,lung,liver,spleen,kidney,bile,urine,heart blood,peripheral blood,muscle in injection location,and muscle in no injection location,were collected for analysis of lidocaine *** was performed with gas chromatography‑mass spectrometry(GC‑MS).From the maximum to the minimum,the order of lidocaine concentration detected in the subarachnoid space‑administered dogs was as follows:CSF in subarachnoid space,waist spinal cord,thoracic spinal cord,CSF in lateral ventricle,lumbar spinal cord,cervical spinal cord,lung,kidney,muscle in injection location,heart,brain,spleen,heart blood,liver,peripheral blood,bile,muscle in no injection location,and *** order of lidocaine concentration detected in the intravenously administered dogs was as followed:Kidney,heart,lung,spleen,brain,liver,peripheral blood,bile,heart blood,cervical spinal cord,thoracic spinal cord,muscle in injection location,lumbar spinal cord,muscle in no injection location,CSF in subarachnoid space,urine,and CSF in lateral *** maximum concentration of lidocaine was detected in the subarachnoid space CSF of subarachnoid space‑administered dead dogs,while in intravenously injected d

关键词： Anesthesia accident distribution of lidocaine forensic medicine forensic toxicological analysis intravenous administration intravenous injection lidocaine postmortem distribution subarachnoid administration subarachnoid anesthesia

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Effect of intravenous administration of Liposomal Prostaglandin E1 on Microcirculation in Patients with ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Intervention

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Chinese Medical Journal 2015年第9期128卷 1147-1150页

作者： Li-Ye Wei Xiang-Hua Fu Wei Li Xi-Le Bi Shi-Ru Bai Kun Xing Yan-Bo Wang Department of Cardiology The First Hospital of Hebei Medical University Shijiazhuang Hebei 050000 China Department of Cardiology The Second Hospital of Hebei Medical University Shijiazhuang Hebei 050000 China

Background：Several studies have demonstrated that primary percutaneous coronary intervention （PCI） can result in reperfusion *** study aims to investigate the effectiveness of liposomal prostaglandin E l （Lipo-PGE1,Alprostadil,Beijing Tide Pharmaceutical Co.,Ltd.） for enhancing microcirculation in reperfusion *** addition,this study determined the optimal administration method for acute ST elevation myocardial infarction （STEMI） patients undergoing primary ***：Totally,68 patients with STEMI were randomly assigned to two groups：intravenous administration ofLipo-PGE 1 （Group A）,and no Lipo-PGE1 administration （Group B）.The corrected thrombolysis in myocardial infarction （TIMI） frame count （cTFC） and myocardial blush grade （MBG） were *** were followed up for 6 *** adverse cardiac events （MACE） were also ***：There was no significant difference in the baseline characteristics between the two *** cTFC parameter in Group A was significantly lower than Group B （18.06 ± 2.06 vs.25.31 ± 2.59,P ＜ 0.01）.The ratio of final MBG grade-3 was significantly higher （P ＜ 0.05） in Group A （87.9％） relative to Group B （65.7％）.There was no significant difference between the two groups in final TIMI-3 flow and *** were followed up for 6 months,and the occurrence of MACE in Group A was significantly lower than that in Group B （6.1％ vs.25.9％ respectively,P ＜ 0.05）.Conclusions：Myocardial microcirculation of reperfusion injury in patients with STEMI,after primary PCI,can be improved by administering Lipo-PGE1.

关键词： intravenous administration Liposomal Prostaglandin E l Primary Percutaneous Coronary Intervention ST Elevation Myocardial Infarction

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Comparative pharmacokinetic studies of borneol in mouse plasma and brain by different administrations

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第12期13卷 990-996页

作者： Jing-yi ZHAO Yang LU Shou-ying DU Xiao SONG Jie BAI Yue WANG Department of Industrial Pharmacy School of Chinese PharmacyBeijing University of Chinese MedicineBeijing 100102China

Borneol,a monoterpenoid alcohol,is used widely,particularly in combined formulas for preventing and curing cardiovascular and cerebrovascular diseases in traditional Chinese *** order to understand the blood and brain pharmacokinetics after intravenous,intranasal,or oral administration and to investigate the superiority and feasibility of intranasal administration,a simple gas chromatographic (GC) method with flame ionization detection (FID) was developed for the quantification of *** samples and brain were collected from mice at 1,3,5,10,20,30,60,90,and 120 min after intravenous,intranasal,or oral administration of borneol at a dosage of 30.0 mg/*** preparations were carried out by liquid-liquid extraction with an internal standard solution of *** pharmacokinetic parameters were calculated by the software of *** calibration curves were linear in the range of 0.11-84.24 μg/ml and 0.16-63.18 μg/g for borneol in plasma and brain,*** methodological and extraction recoveries were both in the range of 85%-115%.The intra-day and inter-day variabilities for plasma and brain samples were ≤5.00% relative standard deviation (RSD).The absolute bioavailabilities F of intranasal and oral administrations were 90.68% and 42.99%.The relative brain targeted coefficients Re of intranasal and oral administrations were 68.37% and 38.40%.The GC-FID method developed could be applied to determination and pharmacokinetic *** borneol from injection was distributed and metabolized fast without absorption *** borneol from oral administration was distributed more slowly and had the lowest absolute *** administration of borneol was quickly absorbed into the blood and brain,was easy to use and had a greater safety than infection,which makes it worthy of further development as an administration route for encephalopathy treatment.

关键词： Borneol intravenous administration lntranasal administration Oral administration Pharmacokinetics

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Enhancing effect of natural borneol on the absorption of geniposide in rat via intranasal administration

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第2期12卷 143-148页

作者： Yang LU Shou-ying DU Xiao-lan CHEN Qing WU Xiao SONG Bing XU Yong-song ZHAI Department of Industrial Pharmacy School of Chinese Pharmacy Beijing University of Chinese Medicine Beijing 100102 China Department of Chinese Pharmacy Guiyang College of Traditional Chinese Medicine Guiyang 550002 China

Both geniposide （Ge） and natural borneol （NB） are bioactive substances derived from traditional Chinese herbs. The effect of NB on the pharmacokinetics of Ge in rat via intranasal administration was investigated. The concentrations of Ge in plasma were determined by reversed-phase high-performance liquid chromatography （HPLC） after intranasal administration of Ge （4 mg/kg） alone and combined with different doses （0.08, 0.8, and 8 mg/kg） of NB. The intravenous administration was given as a reference （4 mg/kg of Ge and 8 mg/kg of NB）. Compared with the intravenous administration, the absolute bioavailability of Ge was 76.14% through intranasal administration combined with NB. Compared with the intranasal administration of Ge alone, Ge could be absorbed rapidly in the nasal cavity combined with NB; the peak time of Ge in the plasma became shorter （3-5 min vs. 40 min）; the peak concentration became higher （1.32-4.25 IJg/ml vs. 0.67 ug/ml）; and, the relative bioavailability of Ge combined with NB was 90.3%-237.8%. The enhancing effect was attenuated as the dose of NB decreased. The results indicated that NB can accelerate the absorption of Ge dose-dependently in the nasal cavity.

关键词： Geniposide Natural borneol Intranasal administration intravenous administration Pharmacokinetics

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Inhalation treatment of lung cancer: the influence of composition, size and shape of nanocarriers on their lung accumulation and retention

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Cancer Biology & Medicine 2014年第1期11卷 44-55页

作者： Olga B.Garbuzenko Gediminas Mainelis Oleh Taratula Tamara Minko Department of Pharmaceutics Ernest Mario School of Pharmacy Rutgers The State University of New Jersey Department of Environmental Sciences Rutgers The State University of New Jersey Environmental and Occupational Health Sciences Institute Department of Pharmaceutical Sciences Oregon State University Rutgers Cancer Institute of New Jersey

Objective： Various nanoparticles have been designed and tested in order to select optimal carriers for the inhalation delivery ofanticancer drugs to the lungs. Methods： q-he following nanocarriers were studied： micelles, liposomes, mesoporous silica nanoparticles （MSNs）, poly propyleneimine （PPI） dendrimer-siRNA complexes nanoparticles, quantum dots （QDs）, and poly （ethylene glycol） polymers. All particles were characterized using the following methods： dynamic light scattering, zeta potential, atomic force microscopy, in vitro cyto- and genotoxicity. In vivo organ distribution of all nanopartides, retention in the lungs, and anticancer effects of liposomes loaded with doxorubicin were examined in nude mice after the pulmonary or intravenous delivery. Results： Significant differences in lung uptake were found after the inhalation delivery of lipid-based and non-lipid-based nanoparticles. The accumulation ofliposomes and miceUes in lungs remained relatively high even 24 h after inhalation when compared with MSNs, Q Ds, and PPI dendrimers. There were notable differences between nanoparticle accumulation in the lungs and other organs 1 and 3 h after inhalation or intravenous administrations, but 24 h after intravenous injection all nanoparticles were mainly accumulated in the liver, kidneys, and spleen. Inhalation delivery of doxorubicin by liposomes significantly enhanced its anticancer effect and prevented severe adverse side effects of the treatment in mice bearing the orthotopic model of lung cancer. Conclusion： The results of the study demonstrate that lipid-based nanocarriers had considerably higher accumulation and longer retention time in the lungs when compared with non-lipid-based carriers after the inhalation delivery. These particles are most suitable for effective inhalation treatment of lung cancer.

关键词： Nanoparticles drug delivery systems intravenous administration lung neoplasms inhalation administration

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intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury

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Neural Regeneration Research 2014年第9期9卷 919-923页

作者： Fatemeh Anbari Mohammad Ali Khalili Ahmad Reza Bahrami Arezoo Khoradmehr Fatemeh Sadeghian Farzaneh Fesahat Ali Nabi Research and Clinical Center for Infertility Shahid Sadoughi University of Medical Sciences Institute of Biotechnology Ferdowsi University of Mashhad

To investigate the supplement of lost nerve cells in rats with traumatic brain injury by intravenous administration of allogenic bone marrow mesenchymal stem cells, this study established a Wistar rat model of traumatic brain injury by weight drop impact acceleration method and administered 3 × 106 rat bone marrow mesenchymal stem cells via the lateral tail vein. At 14 days after cell transplantation, bone marrow mesenchymal stem cells differentiated into neurons and astrocytes in injured rat cerebral cortex and rat neurological function was improved significantly. These findings suggest that intravenously administered bone marrow mesenchymal stem cells can promote nerve cell regeneration in injured cerebral cortex, which supplement the lost nerve cells.

关键词： nerve regeneration bone marrow mesenchymal stem cells traumatic brain injury intravenous administration cell differentiation neurologic function,cerebral cortex rats neural regeneration

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